DLGAP2 — 173 ClinVar variants
All ClinVar germline DLGAP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 140 flagged for review →
1 Conflicting · 11 Benign · 22 Likely benign · 139 Uncertain significance
Full DLGAP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 140
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 88
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DLGAP2 p.Ala1019Gly Uncertain significance Single submitter
- DLGAP2 p.Ala116Thr Uncertain significance Single submitter
- DLGAP2 p.Ala177Thr Uncertain significance Single submitter
- DLGAP2 p.Ala190Val Uncertain significance Single submitter
- DLGAP2 p.Ala269Thr Uncertain significance Single submitter
- DLGAP2 p.Ala402Thr Uncertain significance Single submitter
- DLGAP2 p.Ala534Val Uncertain significance Single submitter
- DLGAP2 p.Ala738Gly Uncertain significance Single submitter
- DLGAP2 p.Ala738Pro Uncertain significance Single submitter
- DLGAP2 p.Ala852Thr Uncertain significance Single submitter
- DLGAP2 p.Ala852Val Uncertain significance Single submitter
- DLGAP2 p.Arg290Gln Uncertain significance Single submitter
- DLGAP2 p.Arg368Gly Uncertain significance Single submitter
- DLGAP2 p.Arg431Ser Uncertain significance Single submitter
- DLGAP2 p.Arg658His Uncertain significance Single submitter
- DLGAP2 p.Arg695Gln Uncertain significance Single submitter
- DLGAP2 p.Arg749Leu Uncertain significance Single submitter
- DLGAP2 p.Arg822Gln Uncertain significance Single submitter
- DLGAP2 p.Asn502Ser Uncertain significance Single submitter
- DLGAP2 p.Asn609His Uncertain significance Single submitter
- DLGAP2 p.Asn674Asp Uncertain significance Single submitter
- DLGAP2 p.Asn931Asp Uncertain significance Single submitter
- DLGAP2 p.Asp154Ala Uncertain significance Single submitter
- DLGAP2 p.Asp174Asn Uncertain significance Single submitter
- DLGAP2 p.Asp174Gly Uncertain significance Single submitter
- DLGAP2 p.Asp301Asn Uncertain significance Single submitter
- DLGAP2 p.Asp348Asn Uncertain significance Single submitter
- DLGAP2 p.Asp362Gly Uncertain significance Single submitter
- DLGAP2 p.Asp490Asn Uncertain significance Single submitter
- DLGAP2 p.Asp698His Uncertain significance Single submitter
- DLGAP2 p.Asp973Asn Uncertain significance Single submitter
- DLGAP2 p.Cys176Arg Uncertain significance Single submitter
- DLGAP2 p.Cys176Phe Uncertain significance Single submitter
- DLGAP2 p.Cys564Trp Uncertain significance Single submitter
- DLGAP2 p.Gln195Lys Uncertain significance Single submitter
- DLGAP2 p.Gln480Leu Uncertain significance Single submitter
- DLGAP2 p.Gln482His Uncertain significance Single submitter
- DLGAP2 p.Glu144Asp Uncertain significance Single submitter
- DLGAP2 p.Glu750Lys Uncertain significance Single submitter
- DLGAP2 p.Gly131Arg Uncertain significance Single submitter
- DLGAP2 p.Gly321Cys Uncertain significance Single submitter
- DLGAP2 p.Gly472Glu Uncertain significance Single submitter
- DLGAP2 p.Gly747Asp Uncertain significance Single submitter
- DLGAP2 p.Gly800Ser Uncertain significance Single submitter
- DLGAP2 p.His155Gln Uncertain significance Single submitter
- DLGAP2 p.His180Pro Uncertain significance Single submitter
- DLGAP2 p.His396Gln Uncertain significance Single submitter
- DLGAP2 p.His97Tyr Uncertain significance Single submitter
- DLGAP2 p.Ile462Val Uncertain significance Single submitter
- DLGAP2 p.Ile717Asn Uncertain significance Single submitter
- DLGAP2 p.Leu1011Gln Uncertain significance Single submitter
- DLGAP2 p.Leu374Met Uncertain significance Single submitter
- DLGAP2 p.Leu388Val Uncertain significance Single submitter
- DLGAP2 p.Leu826Val Uncertain significance Single submitter
- DLGAP2 p.Lys364Arg Uncertain significance Single submitter
- DLGAP2 p.Lys392Asn Uncertain significance Single submitter
- DLGAP2 p.Lys469Asn Uncertain significance Single submitter
- DLGAP2 p.Met951Thr Uncertain significance Single submitter
- DLGAP2 p.Phe767Val Uncertain significance Single submitter
- DLGAP2 p.Pro322Thr Uncertain significance Single submitter
- DLGAP2 p.Pro401Ala Uncertain significance Single submitter
- DLGAP2 p.Pro492Ser Uncertain significance Single submitter
- DLGAP2 p.Pro562Leu Uncertain significance Single submitter
- DLGAP2 p.Pro618Ser Uncertain significance Single submitter
- DLGAP2 p.Pro652Leu Uncertain significance Single submitter
- DLGAP2 p.Pro845Ala Uncertain significance Single submitter
- DLGAP2 p.Pro91Ser Uncertain significance Single submitter
- DLGAP2 p.Ser245Leu Uncertain significance Single submitter
- DLGAP2 p.Ser333Asn Uncertain significance Single submitter
- DLGAP2 p.Ser447Asn Uncertain significance Single submitter
- DLGAP2 p.Ser697Ile Uncertain significance Single submitter
- DLGAP2 p.Ser912Ile Uncertain significance Single submitter
- DLGAP2 p.Thr308Pro Uncertain significance Single submitter
- DLGAP2 p.Thr608Lys Uncertain significance Single submitter
- DLGAP2 p.Thr638Asn Uncertain significance Single submitter
- DLGAP2 p.Thr679Met Uncertain significance Single submitter
- DLGAP2 p.Thr696Ser Uncertain significance Single submitter
- DLGAP2 p.Tyr120Phe Uncertain significance Single submitter
- DLGAP2 p.Tyr170Cys Uncertain significance Single submitter
- DLGAP2 p.Tyr309Cys Uncertain significance Single submitter
- DLGAP2 p.Tyr661Cys Uncertain significance Single submitter
- DLGAP2 p.Tyr925Cys Uncertain significance Single submitter
- DLGAP2 p.Val141Leu Uncertain significance Single submitter
- DLGAP2 p.Val150Leu Uncertain significance Single submitter
- DLGAP2 p.Val528Met Uncertain significance Single submitter
-
DLGAP2 p.Asn662Thr
Uncertain significance
No assertion criteria
DLGAP2-related disorder
-
DLGAP2 p.Leu192Val
Uncertain significance
No assertion criteria
DLGAP2-related disorder
-
DLGAP2 p.Ser85Cys
Uncertain significance
No assertion criteria
DLGAP2-related disorder
Predictors split 51
The independent predictors disagree with each other — read with care.
- DLGAP2 p.Ala1026Val Uncertain significance Single submitter
- DLGAP2 p.Ala893Val Uncertain significance Single submitter
- DLGAP2 p.Ala936Thr Uncertain significance Single submitter
- DLGAP2 p.Arg1028Gln Uncertain significance Single submitter
- DLGAP2 p.Arg187Leu Uncertain significance Single submitter
- DLGAP2 p.Arg658Cys Uncertain significance Single submitter
- DLGAP2 p.Arg749Trp Uncertain significance Single submitter
- DLGAP2 p.Arg822Trp Uncertain significance Single submitter
- DLGAP2 p.Arg834Trp Uncertain significance Single submitter
- DLGAP2 p.Asp260Ala Uncertain significance Single submitter
- DLGAP2 p.Asp964Glu Uncertain significance Single submitter
- DLGAP2 p.Asp973Tyr Uncertain significance Single submitter
- DLGAP2 p.Cys354Arg Uncertain significance Single submitter
- DLGAP2 p.Gln967Leu Uncertain significance Single submitter
- DLGAP2 p.Glu550Gln Uncertain significance Single submitter
- DLGAP2 p.Glu857Ala Uncertain significance Single submitter
-
DLGAP2 p.Glu892Gln
Uncertain significance
Single submitter
DLGAP2-related disorder
- DLGAP2 p.Glu981Gly Uncertain significance Single submitter
- DLGAP2 p.Gly718Arg Uncertain significance Single submitter
- DLGAP2 p.Gly947Ser Uncertain significance Single submitter
- DLGAP2 p.His142Pro Uncertain significance Single submitter
- DLGAP2 p.His268Asn Uncertain significance Single submitter
- DLGAP2 p.His268Pro Uncertain significance Single submitter
- DLGAP2 p.Ile956Thr Uncertain significance Single submitter
- DLGAP2 p.Leu246Val Uncertain significance Single submitter
- DLGAP2 p.Leu710Phe Uncertain significance Single submitter
- DLGAP2 p.Lys350Glu Uncertain significance Single submitter
- DLGAP2 p.Lys459Asn Uncertain significance Single submitter
- DLGAP2 p.Met1024Thr Uncertain significance Single submitter
- DLGAP2 p.Met889Leu Uncertain significance Single submitter
- DLGAP2 p.Pro592Leu Uncertain significance Single submitter
- DLGAP2 p.Pro614Thr Uncertain significance Single submitter
- DLGAP2 p.Pro616Leu Uncertain significance Single submitter
- DLGAP2 p.Pro851Arg Uncertain significance Single submitter
- DLGAP2 p.Ser136Leu Uncertain significance Single submitter
- DLGAP2 p.Ser140Leu Uncertain significance Single submitter
- DLGAP2 p.Ser157Cys Uncertain significance Single submitter
- DLGAP2 p.Ser370Ala Uncertain significance Single submitter
- DLGAP2 p.Ser372Ala Uncertain significance Single submitter
- DLGAP2 p.Ser597Phe Uncertain significance Single submitter
- DLGAP2 p.Ser645Cys Uncertain significance Single submitter
- DLGAP2 p.Ser869Leu Uncertain significance Single submitter
- DLGAP2 p.Ser942Leu Uncertain significance Single submitter
- DLGAP2 p.Thr1004Ile Uncertain significance Single submitter
- DLGAP2 p.Thr311Met Uncertain significance Single submitter
- DLGAP2 p.Thr602Ile Uncertain significance Single submitter
- DLGAP2 p.Thr630Ser Uncertain significance Single submitter
- DLGAP2 p.Thr941Met Uncertain significance Single submitter
- DLGAP2 p.Val543Met Uncertain significance Single submitter
-
DLGAP2 p.Arg713His
Likely benign
No assertion criteria
DLGAP2-related disorder
- DLGAP2 p.Arg970Gln Uncertain significance No assertion criteria
All DLGAP2 variants
Conflicting classifications of pathogenicity 1
- p.Val605Ile Single submitter ⚠
Benign 11
- c.1810+14A>G Multiple submitters
- c.2160+19C>G Multiple submitters
- p.Glu678= Multiple submitters
- p.Pro464Gln Multiple submitters
- p.Arg214Lys Single submitter
- p.Asp171Asn Single submitter
- p.Ala3Ser No assertion criteria DLGAP2-related disorder
- p.Arg658= No assertion criteria DLGAP2-related disorder
- p.Asp391Glu No assertion criteria DLGAP2-related disorder
- p.Pro652= No assertion criteria DLGAP2-related disorder
- p.Thr792= No assertion criteria DLGAP2-related disorder
Likely benign 22
- p.Ala402Ser Single submitter
- p.Asn347Ser Single submitter
- p.Asp58= Single submitter
- p.Ile471= Single submitter
- p.Pro940= Single submitter
- p.Thr29= Single submitter
- p.Thr664Met Single submitter
- c.107-10G>C No assertion criteria DLGAP2-related disorder
- c.1231-10C>G No assertion criteria DLGAP2-related disorder
- c.1810+10C>T No assertion criteria DLGAP2-related disorder
- c.2202+9C>T No assertion criteria DLGAP2-related disorder
- c.2797-15TG[5] No assertion criteria DLGAP2-related disorder
- c.2949+5G>C No assertion criteria DLGAP2-related disorder
- p.Arg646His No assertion criteria DLGAP2-related disorder
- p.Arg713His No assertion criteria DLGAP2-related disorder ⚠
- p.Glu1039= No assertion criteria DLGAP2-related disorder
- p.Leu12= No assertion criteria DLGAP2-related disorder
- p.Lys273= No assertion criteria DLGAP2-related disorder
- p.Pro1049= No assertion criteria DLGAP2-related disorder
- p.Pro322= No assertion criteria DLGAP2-related disorder
- p.Ser489= No assertion criteria DLGAP2-related disorder
- p.Ser628= No assertion criteria DLGAP2-related disorder
Uncertain significance 139
- p.Ala1019Gly Single submitter ⚠
- p.Ala1026Val Single submitter ⚠
- p.Ala116Thr Single submitter ⚠
- p.Ala177Thr Single submitter ⚠
- p.Ala190Val Single submitter ⚠
- p.Ala269Thr Single submitter ⚠
- p.Ala402Thr Single submitter ⚠
- p.Ala534Val Single submitter ⚠
- p.Ala738Gly Single submitter ⚠
- p.Ala738Pro Single submitter ⚠
- p.Ala852Thr Single submitter ⚠
- p.Ala852Val Single submitter ⚠
- p.Ala893Val Single submitter ⚠
- p.Ala936Thr Single submitter ⚠
- p.Arg1028Gln Single submitter ⚠
- p.Arg187Leu Single submitter ⚠
- p.Arg290Gln Single submitter ⚠
- p.Arg368Gly Single submitter ⚠
- p.Arg431Ser Single submitter ⚠
- p.Arg658Cys Single submitter ⚠
- p.Arg658His Single submitter ⚠
- p.Arg695Gln Single submitter ⚠
- p.Arg749Leu Single submitter ⚠
- p.Arg749Trp Single submitter ⚠
- p.Arg822Gln Single submitter ⚠
- p.Arg822Trp Single submitter ⚠
- p.Arg834Trp Single submitter ⚠
- p.Asn502Ser Single submitter ⚠
- p.Asn609His Single submitter ⚠
- p.Asn674Asp Single submitter ⚠
- p.Asn931Asp Single submitter ⚠
- p.Asp154Ala Single submitter ⚠
- p.Asp174Asn Single submitter ⚠
- p.Asp174Gly Single submitter ⚠
- p.Asp260Ala Single submitter ⚠
- p.Asp301Asn Single submitter ⚠
- p.Asp348Asn Single submitter ⚠
- p.Asp362Gly Single submitter ⚠
- p.Asp490Asn Single submitter ⚠
- p.Asp698His Single submitter ⚠
- p.Asp964Glu Single submitter ⚠
- p.Asp973Asn Single submitter ⚠
- p.Asp973Tyr Single submitter ⚠
- p.Cys176Arg Single submitter ⚠
- p.Cys176Phe Single submitter ⚠
- p.Cys354Arg Single submitter ⚠
- p.Cys564Trp Single submitter ⚠
- p.Gln195Lys Single submitter ⚠
- p.Gln480Leu Single submitter ⚠
- p.Gln482His Single submitter ⚠
- p.Gln967Leu Single submitter ⚠
- p.Glu144Asp Single submitter ⚠
- p.Glu550Gln Single submitter ⚠
- p.Glu750Lys Single submitter ⚠
- p.Glu857Ala Single submitter ⚠
- p.Glu892Gln Single submitter DLGAP2-related disorder ⚠
- p.Glu981Gly Single submitter ⚠
- p.Gly131Arg Single submitter ⚠
- p.Gly321Cys Single submitter ⚠
- p.Gly472Glu Single submitter ⚠
- p.Gly718Arg Single submitter ⚠
- p.Gly747Asp Single submitter ⚠
- p.Gly800Ser Single submitter ⚠
- p.Gly947Ser Single submitter ⚠
- p.His142Pro Single submitter ⚠
- p.His155Gln Single submitter ⚠
- p.His180Pro Single submitter ⚠
- p.His268Asn Single submitter ⚠
- p.His268Pro Single submitter ⚠
- p.His396Gln Single submitter ⚠
- p.His97Tyr Single submitter ⚠
- p.Ile462Val Single submitter ⚠
- p.Ile717Asn Single submitter ⚠
- p.Ile956Thr Single submitter ⚠
- p.Leu1011Gln Single submitter ⚠
- p.Leu246Val Single submitter ⚠
- p.Leu374Met Single submitter ⚠
- p.Leu388Val Single submitter ⚠
- p.Leu710Phe Single submitter ⚠
- p.Leu826Val Single submitter ⚠
- p.Lys350Glu Single submitter ⚠
- p.Lys364Arg Single submitter ⚠
- p.Lys392Asn Single submitter ⚠
- p.Lys459Asn Single submitter ⚠
- p.Lys469Asn Single submitter ⚠
- p.Met1024Thr Single submitter ⚠
- p.Met889Leu Single submitter ⚠
- p.Met951Thr Single submitter ⚠
- p.Phe767Val Single submitter ⚠
- p.Pro322Thr Single submitter ⚠
- p.Pro401Ala Single submitter ⚠
- p.Pro492Ser Single submitter ⚠
- p.Pro562Leu Single submitter ⚠
- p.Pro592Leu Single submitter ⚠
- p.Pro614Thr Single submitter ⚠
- p.Pro616Leu Single submitter ⚠
- p.Pro618Ser Single submitter ⚠
- p.Pro652Leu Single submitter ⚠
- p.Pro845Ala Single submitter ⚠
- p.Pro851Arg Single submitter ⚠
- p.Pro91Ser Single submitter ⚠
- p.Ser136Leu Single submitter ⚠
- p.Ser140Leu Single submitter ⚠
- p.Ser157Cys Single submitter ⚠
- p.Ser245Leu Single submitter ⚠
- p.Ser333Asn Single submitter ⚠
- p.Ser370Ala Single submitter ⚠
- p.Ser372Ala Single submitter ⚠
- p.Ser447Asn Single submitter ⚠
- p.Ser457fs Single submitter
- p.Ser597Phe Single submitter ⚠
- p.Ser645Cys Single submitter ⚠
- p.Ser697Ile Single submitter ⚠
- p.Ser869Leu Single submitter ⚠
- p.Ser912Ile Single submitter ⚠
- p.Ser942Leu Single submitter ⚠
- p.Thr1004Ile Single submitter ⚠
- p.Thr308Pro Single submitter ⚠
- p.Thr311Met Single submitter ⚠
- p.Thr602Ile Single submitter ⚠
- p.Thr608Lys Single submitter ⚠
- p.Thr630Ser Single submitter ⚠
- p.Thr638Asn Single submitter ⚠
- p.Thr679Met Single submitter ⚠
- p.Thr696Ser Single submitter ⚠
- p.Thr941Met Single submitter ⚠
- p.Tyr120Phe Single submitter ⚠
- p.Tyr170Cys Single submitter ⚠
- p.Tyr309Cys Single submitter ⚠
- p.Tyr661Cys Single submitter ⚠
- p.Tyr925Cys Single submitter ⚠
- p.Val141Leu Single submitter ⚠
- p.Val150Leu Single submitter ⚠
- p.Val528Met Single submitter ⚠
- p.Val543Met Single submitter ⚠
- p.Arg970Gln No assertion criteria ⚠
- p.Asn662Thr No assertion criteria DLGAP2-related disorder ⚠
- p.Leu192Val No assertion criteria DLGAP2-related disorder ⚠
- p.Ser85Cys No assertion criteria DLGAP2-related disorder ⚠