DMKN — 8 ClinVar variants
All ClinVar germline DMKN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 3 flagged for review →
1 Benign · 4 Likely benign · 3 Uncertain significance
Full DMKN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 3
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 1
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 2
The independent predictors disagree with each other — read with care.
All DMKN variants
Benign 1
- p.280GSSG[4] Single submitter
Likely benign 4
- p.Ala417Thr Single submitter
- p.Gly284Ser Single submitter
- p.His111Arg Single submitter
- p.Ser252= Single submitter
Uncertain significance 3
- p.Gly100Arg Single submitter ⚠
- p.Gly27Arg Single submitter ⚠
- p.Ser281Gly Single submitter ⚠