DNAJA2 — 25 ClinVar variants
All ClinVar germline DNAJA2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
25 Uncertain significance
Full DNAJA2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAJA2 p.Arg112Gly Uncertain significance Single submitter
- DNAJA2 p.Arg165Gln Uncertain significance Single submitter
- DNAJA2 p.Arg201Ser Uncertain significance Single submitter
- DNAJA2 p.Arg68Lys Uncertain significance Single submitter
- DNAJA2 p.Arg75Trp Uncertain significance Single submitter
- DNAJA2 p.Asp115Asn Uncertain significance Single submitter
- DNAJA2 p.Asp222Gly Uncertain significance Single submitter
- DNAJA2 p.Glu23Lys Uncertain significance Single submitter
- DNAJA2 p.Gly150Ser Uncertain significance Single submitter
- DNAJA2 p.His118Gln Uncertain significance Single submitter
- DNAJA2 p.Ser153Pro Uncertain significance Single submitter
- DNAJA2 p.Val221Ile Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- DNAJA2 p.Gly79Ser Uncertain significance Multiple submitters
- DNAJA2 p.Arg107Gln Uncertain significance Single submitter
- DNAJA2 p.Arg110Gly Uncertain significance Single submitter
- DNAJA2 p.Arg388His Uncertain significance Single submitter
- DNAJA2 p.Glu375Ala Uncertain significance Single submitter
- DNAJA2 p.Ile12Met Uncertain significance Single submitter
- DNAJA2 p.Ile87Val Uncertain significance Single submitter
- DNAJA2 p.Leu74Val Uncertain significance Single submitter
- DNAJA2 p.Lys215Arg Uncertain significance Single submitter
- DNAJA2 p.Phe376Cys Uncertain significance Single submitter
- DNAJA2 p.Tyr271Cys Uncertain significance Single submitter
- DNAJA2 p.Val276Ile Uncertain significance Single submitter
- DNAJA2 p.Val276Leu Uncertain significance Single submitter
All DNAJA2 variants
Uncertain significance 25
- p.Gly79Ser Multiple submitters ⚠
- p.Arg107Gln Single submitter ⚠
- p.Arg110Gly Single submitter ⚠
- p.Arg112Gly Single submitter ⚠
- p.Arg165Gln Single submitter ⚠
- p.Arg201Ser Single submitter ⚠
- p.Arg388His Single submitter ⚠
- p.Arg68Lys Single submitter ⚠
- p.Arg75Trp Single submitter ⚠
- p.Asp115Asn Single submitter ⚠
- p.Asp222Gly Single submitter ⚠
- p.Glu23Lys Single submitter ⚠
- p.Glu375Ala Single submitter ⚠
- p.Gly150Ser Single submitter ⚠
- p.His118Gln Single submitter ⚠
- p.Ile12Met Single submitter ⚠
- p.Ile87Val Single submitter ⚠
- p.Leu74Val Single submitter ⚠
- p.Lys215Arg Single submitter ⚠
- p.Phe376Cys Single submitter ⚠
- p.Ser153Pro Single submitter ⚠
- p.Tyr271Cys Single submitter ⚠
- p.Val221Ile Single submitter ⚠
- p.Val276Ile Single submitter ⚠
- p.Val276Leu Single submitter ⚠