DNAJA4 — 65 ClinVar variants
All ClinVar germline DNAJA4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
4 Likely benign · 61 Uncertain significance
Full DNAJA4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAJA4 p.Ala25Val Uncertain significance Single submitter
- DNAJA4 p.Ala314Val Uncertain significance Single submitter
- DNAJA4 p.Arg255Gln Uncertain significance Single submitter
- DNAJA4 p.Arg305Cys Uncertain significance Single submitter
- DNAJA4 p.Asp258Tyr Uncertain significance Single submitter
- DNAJA4 p.Asp65His Uncertain significance Single submitter
- DNAJA4 p.Gln324Glu Uncertain significance Single submitter
- DNAJA4 p.Glu195Lys Uncertain significance Single submitter
- DNAJA4 p.Gly199Arg Uncertain significance Single submitter
- DNAJA4 p.His377Gln Uncertain significance Single submitter
- DNAJA4 p.Ile174Met Uncertain significance Single submitter
- DNAJA4 p.Ile242Thr Uncertain significance Single submitter
- DNAJA4 p.Ile285Thr Uncertain significance Single submitter
- DNAJA4 p.Ile288Thr Uncertain significance Single submitter
- DNAJA4 p.Ile323Thr Uncertain significance Single submitter
- DNAJA4 p.Ile48Thr Uncertain significance Single submitter
- DNAJA4 p.Lys207Met Uncertain significance Single submitter
- DNAJA4 p.Lys23Glu Uncertain significance Single submitter
- DNAJA4 p.Pro341Ser Uncertain significance Single submitter
- DNAJA4 p.Tyr52His Uncertain significance Single submitter
- DNAJA4 p.Val171Ile Uncertain significance Single submitter
- DNAJA4 p.Val243Met Uncertain significance Single submitter
Predictors split 38
The independent predictors disagree with each other — read with care.
- DNAJA4 p.Arg157Trp Uncertain significance Single submitter
- DNAJA4 p.Arg187Cys Uncertain significance Single submitter
- DNAJA4 p.Arg193Leu Uncertain significance Single submitter
- DNAJA4 p.Arg350Gly Uncertain significance Single submitter
- DNAJA4 p.Arg350Pro Uncertain significance Single submitter
- DNAJA4 p.Arg98Trp Uncertain significance Single submitter
- DNAJA4 p.Asp384Gly Uncertain significance Single submitter
- DNAJA4 p.Gln266Pro Uncertain significance Single submitter
- DNAJA4 p.Glu180Lys Uncertain significance Single submitter
- DNAJA4 p.Glu20Gln Uncertain significance Single submitter
- DNAJA4 p.Glu234Lys Uncertain significance Single submitter
- DNAJA4 p.Glu69Gln Uncertain significance Single submitter
- DNAJA4 p.Gly387Arg Uncertain significance Single submitter
- DNAJA4 p.Ile10Val Uncertain significance Single submitter
- DNAJA4 p.Ile166Met Uncertain significance Single submitter
- DNAJA4 p.Ile188Val Uncertain significance Single submitter
- DNAJA4 p.Leu286Val Uncertain significance Single submitter
- DNAJA4 p.Leu343Val Uncertain significance Single submitter
- DNAJA4 p.Leu347Phe Uncertain significance Single submitter
- DNAJA4 p.Leu47Phe Uncertain significance Single submitter
- DNAJA4 p.Lys201Arg Uncertain significance Single submitter
- DNAJA4 p.Lys247Glu Uncertain significance Single submitter
- DNAJA4 p.Lys28Asn Uncertain significance Single submitter
- DNAJA4 p.Lys32Gln Uncertain significance Single submitter
- DNAJA4 p.Lys339Asn Uncertain significance Single submitter
- DNAJA4 p.Met159Ile Uncertain significance Single submitter
- DNAJA4 p.Met359Thr Uncertain significance Single submitter
- DNAJA4 p.Pro39Ala Uncertain significance Single submitter
- DNAJA4 p.Ser113Pro Uncertain significance Single submitter
- DNAJA4 p.Ser147Leu Uncertain significance Single submitter
- DNAJA4 p.Ser77Leu Uncertain significance Single submitter
- DNAJA4 p.Thr124Met Uncertain significance Single submitter
- DNAJA4 p.Thr277Met Uncertain significance Single submitter
- DNAJA4 p.Thr396Met Uncertain significance Single submitter
- DNAJA4 p.Tyr33Cys Uncertain significance Single submitter
- DNAJA4 p.Val108Ile Uncertain significance Single submitter
- DNAJA4 p.Val114Leu Uncertain significance Single submitter
- DNAJA4 p.Val362Met Uncertain significance Single submitter
All DNAJA4 variants
Likely benign 4
- c.132+1348_132+1349del Single submitter
- c.-14C>T Single submitter
- c.-7A>G Single submitter
- p.Asp306Asn Single submitter
Uncertain significance 61
- p.Ala25Val Single submitter ⚠
- p.Ala314Val Single submitter ⚠
- p.Arg157Trp Single submitter ⚠
- p.Arg187Cys Single submitter ⚠
- p.Arg193Leu Single submitter ⚠
- p.Arg255Gln Single submitter ⚠
- p.Arg305Cys Single submitter ⚠
- p.Arg350Gly Single submitter ⚠
- p.Arg350Pro Single submitter ⚠
- p.Arg98Trp Single submitter ⚠
- p.Asp258Tyr Single submitter ⚠
- p.Asp384Gly Single submitter ⚠
- p.Asp65His Single submitter ⚠
- p.Gln266Pro Single submitter ⚠
- p.Gln324Glu Single submitter ⚠
- p.Glu180Lys Single submitter ⚠
- p.Glu195Lys Single submitter ⚠
- p.Glu20Gln Single submitter ⚠
- p.Glu234Lys Single submitter ⚠
- p.Glu69Gln Single submitter ⚠
- p.Gly199Arg Single submitter ⚠
- p.Gly387Arg Single submitter ⚠
- p.His377Gln Single submitter ⚠
- p.Ile10Val Single submitter ⚠
- p.Ile166Met Single submitter ⚠
- p.Ile174Met Single submitter ⚠
- p.Ile188Val Single submitter ⚠
- p.Ile242Thr Single submitter ⚠
- p.Ile285Thr Single submitter ⚠
- p.Ile288Thr Single submitter ⚠
- p.Ile323Thr Single submitter ⚠
- p.Ile48Thr Single submitter ⚠
- p.Leu286Val Single submitter ⚠
- p.Leu343Val Single submitter ⚠
- p.Leu347Phe Single submitter ⚠
- p.Leu47Phe Single submitter ⚠
- p.Lys201Arg Single submitter ⚠
- p.Lys207Met Single submitter ⚠
- p.Lys23Glu Single submitter ⚠
- p.Lys247Glu Single submitter ⚠
- p.Lys28Asn Single submitter ⚠
- p.Lys32Gln Single submitter ⚠
- p.Lys339Asn Single submitter ⚠
- p.Met159Ile Single submitter ⚠
- p.Met359Thr Single submitter ⚠
- p.Pro341Ser Single submitter ⚠
- p.Pro39Ala Single submitter ⚠
- p.Ser113Pro Single submitter ⚠
- p.Ser147Leu Single submitter ⚠
- p.Ser77Leu Single submitter ⚠
- p.Thr124Met Single submitter ⚠
- p.Thr277Met Single submitter ⚠
- p.Thr396Met Single submitter ⚠
- p.Trp9Ser Single submitter
- p.Tyr33Cys Single submitter ⚠
- p.Tyr52His Single submitter ⚠
- p.Val108Ile Single submitter ⚠
- p.Val114Leu Single submitter ⚠
- p.Val171Ile Single submitter ⚠
- p.Val243Met Single submitter ⚠
- p.Val362Met Single submitter ⚠