DNAJC1 — 77 ClinVar variants
All ClinVar germline DNAJC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 72 flagged for review →
6 Likely benign · 71 Uncertain significance
Full DNAJC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 72
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAJC1 p.Ala263Ser Uncertain significance Single submitter
- DNAJC1 p.Ala3Thr Uncertain significance Single submitter
- DNAJC1 p.Ala417Gly Uncertain significance Single submitter
- DNAJC1 p.Ala455Val Uncertain significance Single submitter
- DNAJC1 p.Ala490Gly Uncertain significance Single submitter
- DNAJC1 p.Ala524Ser Uncertain significance Single submitter
- DNAJC1 p.Ala537Thr Uncertain significance Single submitter
- DNAJC1 p.Arg107Thr Uncertain significance Single submitter
- DNAJC1 p.Arg321Gln Uncertain significance Single submitter
- DNAJC1 p.Arg362Leu Uncertain significance Single submitter
- DNAJC1 p.Arg414Gln Uncertain significance Single submitter
- DNAJC1 p.Arg441Gln Uncertain significance Single submitter
- DNAJC1 p.Arg491Gln Uncertain significance Single submitter
- DNAJC1 p.Asn210Thr Uncertain significance Single submitter
- DNAJC1 p.Asp300Ala Uncertain significance Single submitter
- DNAJC1 p.Asp408Gly Uncertain significance Single submitter
- DNAJC1 p.Cys5Arg Uncertain significance Single submitter
- DNAJC1 p.Gln63His Uncertain significance Single submitter
- DNAJC1 p.Glu259Gln Uncertain significance Single submitter
- DNAJC1 p.Glu270Gln Uncertain significance Single submitter
- DNAJC1 p.Glu329Ala Uncertain significance Single submitter
- DNAJC1 p.Glu458Lys Uncertain significance Single submitter
- DNAJC1 p.Glu49Asp Uncertain significance Single submitter
- DNAJC1 p.Gly205Ser Uncertain significance Single submitter
- DNAJC1 p.Gly348Glu Uncertain significance Single submitter
- DNAJC1 p.Gly419Arg Uncertain significance Single submitter
- DNAJC1 p.Gly47Ser Uncertain significance Single submitter
- DNAJC1 p.Gly51Val Uncertain significance Single submitter
- DNAJC1 p.His240Gln Uncertain significance Single submitter
- DNAJC1 p.Ile356Thr Uncertain significance Single submitter
- DNAJC1 p.Leu129Pro Uncertain significance Single submitter
- DNAJC1 p.Leu507Met Uncertain significance Single submitter
- DNAJC1 p.Leu58Ser Uncertain significance Single submitter
- DNAJC1 p.Lys193Arg Uncertain significance Single submitter
- DNAJC1 p.Met215Ile Uncertain significance Single submitter
- DNAJC1 p.Phe22Leu Uncertain significance Single submitter
- DNAJC1 p.Pro281Thr Uncertain significance Single submitter
- DNAJC1 p.Pro350Ser Uncertain significance Single submitter
- DNAJC1 p.Pro528Arg Uncertain significance Single submitter
- DNAJC1 p.Ser172Ala Uncertain significance Single submitter
- DNAJC1 p.Ser430Ala Uncertain significance Single submitter
- DNAJC1 p.Ser531Arg Uncertain significance Single submitter
- DNAJC1 p.Ser554Gly Uncertain significance Single submitter
- DNAJC1 p.Ser78Ala Uncertain significance Single submitter
- DNAJC1 p.Thr322Ile Uncertain significance Single submitter
- DNAJC1 p.Thr91Ser Uncertain significance Single submitter
- DNAJC1 p.Trp171Ser Uncertain significance Single submitter
- DNAJC1 p.Tyr142Phe Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- DNAJC1 p.Arg445Gln Uncertain significance Single submitter
- DNAJC1 p.Arg46Leu Uncertain significance Single submitter
- DNAJC1 p.Arg514Met Uncertain significance Single submitter
- DNAJC1 p.Asn151Ser Uncertain significance Single submitter
- DNAJC1 p.Asp221Asn Uncertain significance Single submitter
- DNAJC1 p.Cys526Phe Uncertain significance Single submitter
- DNAJC1 p.Glu329Lys Uncertain significance Single submitter
- DNAJC1 p.Glu60Ala Uncertain significance Single submitter
- DNAJC1 p.Gly18Glu Uncertain significance Single submitter
- DNAJC1 p.Gly419Trp Uncertain significance Single submitter
- DNAJC1 p.Leu32Met Uncertain significance Single submitter
- DNAJC1 p.Leu505Met Uncertain significance Single submitter
- DNAJC1 p.Lys187Gln Uncertain significance Single submitter
- DNAJC1 p.Lys258Asn Uncertain significance Single submitter
- DNAJC1 p.Lys277Glu Uncertain significance Single submitter
- DNAJC1 p.Pro12His Uncertain significance Single submitter
- DNAJC1 p.Pro44Leu Uncertain significance Single submitter
- DNAJC1 p.Pro457Leu Likely benign Single submitter
- DNAJC1 p.Pro496Leu Uncertain significance Single submitter
- DNAJC1 p.Ser6Phe Uncertain significance Single submitter
- DNAJC1 p.Thr104Ile Uncertain significance Single submitter
- DNAJC1 p.Thr435Ile Uncertain significance Single submitter
- DNAJC1 p.Tyr512His Uncertain significance Single submitter
- DNAJC1 p.Val287Ile Uncertain significance Single submitter
All DNAJC1 variants
Likely benign 6
- p.Ala417Thr Single submitter
- p.Gly419Glu Single submitter
- p.Leu451Pro Single submitter
- p.Pro457Leu Single submitter ⚠
- p.Pro528= Single submitter
- p.Thr331= Single submitter
Uncertain significance 71
- p.Ala263Ser Single submitter ⚠
- p.Ala3Thr Single submitter ⚠
- p.Ala417Gly Single submitter ⚠
- p.Ala455Val Single submitter ⚠
- p.Ala490Gly Single submitter ⚠
- p.Ala524Ser Single submitter ⚠
- p.Ala537Thr Single submitter ⚠
- p.Arg107Thr Single submitter ⚠
- p.Arg321Gln Single submitter ⚠
- p.Arg362Leu Single submitter ⚠
- p.Arg414Gln Single submitter ⚠
- p.Arg441Gln Single submitter ⚠
- p.Arg445Gln Single submitter ⚠
- p.Arg46Leu Single submitter ⚠
- p.Arg491Gln Single submitter ⚠
- p.Arg514Met Single submitter ⚠
- p.Asn151Ser Single submitter ⚠
- p.Asn210Thr Single submitter ⚠
- p.Asp221Asn Single submitter ⚠
- p.Asp300Ala Single submitter ⚠
- p.Asp408Gly Single submitter ⚠
- p.Cys526Phe Single submitter ⚠
- p.Cys5Arg Single submitter ⚠
- p.Gln63His Single submitter ⚠
- p.Glu259Gln Single submitter ⚠
- p.Glu270Gln Single submitter ⚠
- p.Glu329Ala Single submitter ⚠
- p.Glu329Lys Single submitter ⚠
- p.Glu458Lys Single submitter ⚠
- p.Glu49Asp Single submitter ⚠
- p.Glu60Ala Single submitter ⚠
- p.Gly18Glu Single submitter ⚠
- p.Gly205Ser Single submitter ⚠
- p.Gly348Glu Single submitter ⚠
- p.Gly419Arg Single submitter ⚠
- p.Gly419Trp Single submitter ⚠
- p.Gly47Ser Single submitter ⚠
- p.Gly51Val Single submitter ⚠
- p.His240Gln Single submitter ⚠
- p.Ile356Thr Single submitter ⚠
- p.Leu129Pro Single submitter ⚠
- p.Leu32Met Single submitter ⚠
- p.Leu505Met Single submitter ⚠
- p.Leu507Met Single submitter ⚠
- p.Leu58Ser Single submitter ⚠
- p.Lys187Gln Single submitter ⚠
- p.Lys193Arg Single submitter ⚠
- p.Lys258Asn Single submitter ⚠
- p.Lys277Glu Single submitter ⚠
- p.Met215Ile Single submitter ⚠
- p.Phe22Leu Single submitter ⚠
- p.Pro12His Single submitter ⚠
- p.Pro281Thr Single submitter ⚠
- p.Pro350Ser Single submitter ⚠
- p.Pro44Leu Single submitter ⚠
- p.Pro496Leu Single submitter ⚠
- p.Pro528Arg Single submitter ⚠
- p.Ser172Ala Single submitter ⚠
- p.Ser430Ala Single submitter ⚠
- p.Ser531Arg Single submitter ⚠
- p.Ser554Gly Single submitter ⚠
- p.Ser6Phe Single submitter ⚠
- p.Ser78Ala Single submitter ⚠
- p.Thr104Ile Single submitter ⚠
- p.Thr322Ile Single submitter ⚠
- p.Thr435Ile Single submitter ⚠
- p.Thr91Ser Single submitter ⚠
- p.Trp171Ser Single submitter ⚠
- p.Tyr142Phe Single submitter ⚠
- p.Tyr512His Single submitter ⚠
- p.Val287Ile Single submitter ⚠