DNAJC11 — 63 ClinVar variants
All ClinVar germline DNAJC11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
3 Benign · 1 Likely benign · 59 Uncertain significance
Full DNAJC11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAJC11 p.Ala198Val Uncertain significance Single submitter
- DNAJC11 p.Ala306Thr Uncertain significance Single submitter
- DNAJC11 p.Ala55Val Uncertain significance Single submitter
- DNAJC11 p.Arg405His Uncertain significance Single submitter
- DNAJC11 p.Arg554Lys Uncertain significance Single submitter
- DNAJC11 p.Asp318Asn Uncertain significance Single submitter
- DNAJC11 p.Glu29Asp Uncertain significance Single submitter
- DNAJC11 p.Glu29Val Uncertain significance Single submitter
- DNAJC11 p.Glu481Lys Uncertain significance Single submitter
- DNAJC11 p.Glu522Lys Uncertain significance Single submitter
- DNAJC11 p.Gly253Ser Uncertain significance Single submitter
- DNAJC11 p.Gly559Glu Uncertain significance Single submitter
- DNAJC11 p.Ile453Thr Uncertain significance Single submitter
- DNAJC11 p.Leu10Val Uncertain significance Single submitter
- DNAJC11 p.Leu528Val Uncertain significance Single submitter
- DNAJC11 p.Met403Arg Uncertain significance Single submitter
- DNAJC11 p.Met403Val Uncertain significance Single submitter
- DNAJC11 p.Phe197Leu Uncertain significance Single submitter
- DNAJC11 p.Ser185Leu Uncertain significance Single submitter
- DNAJC11 p.Tyr469Asn Uncertain significance Single submitter
- DNAJC11 p.Val285Ile Uncertain significance Single submitter
- DNAJC11 p.Val348Ile Uncertain significance Single submitter
- DNAJC11 p.Val361Ile Uncertain significance Single submitter
- DNAJC11 p.Val465Ile Uncertain significance Single submitter
- DNAJC11 p.Val465Leu Uncertain significance Single submitter
- DNAJC11 p.Val473Ile Uncertain significance Single submitter
- DNAJC11 p.Val534Ile Uncertain significance Single submitter
- DNAJC11 p.Val538Met Uncertain significance Single submitter
- DNAJC11 p.Val93Ile Uncertain significance Single submitter
Predictors split 30
The independent predictors disagree with each other — read with care.
- DNAJC11 p.Ala215Thr Uncertain significance Single submitter
- DNAJC11 p.Ala428Thr Uncertain significance Single submitter
- DNAJC11 p.Ala441Thr Uncertain significance Single submitter
- DNAJC11 p.Arg229His Uncertain significance Single submitter
- DNAJC11 p.Arg248Cys Uncertain significance Single submitter
- DNAJC11 p.Arg345Gly Uncertain significance Single submitter
- DNAJC11 p.Asp143His Uncertain significance Single submitter
- DNAJC11 p.Asp71Glu Uncertain significance Single submitter
- DNAJC11 p.Gln311Glu Uncertain significance Single submitter
- DNAJC11 p.Gln433His Uncertain significance Single submitter
- DNAJC11 p.Glu105Gln Uncertain significance Single submitter
- DNAJC11 p.Gly275Ser Uncertain significance Single submitter
- DNAJC11 p.Ile308Met Uncertain significance Single submitter
- DNAJC11 p.Ile453Asn Uncertain significance Single submitter
- DNAJC11 p.Leu406Val Uncertain significance Single submitter
- DNAJC11 p.Leu535Pro Uncertain significance Single submitter
- DNAJC11 p.Leu535Val Uncertain significance Single submitter
- DNAJC11 p.Lys206Glu Uncertain significance Single submitter
- DNAJC11 p.Lys342Thr Uncertain significance Single submitter
- DNAJC11 p.Lys418Gln Uncertain significance Single submitter
- DNAJC11 p.Lys435Gln Uncertain significance Single submitter
- DNAJC11 p.Lys471Asn Uncertain significance Single submitter
- DNAJC11 p.Phe314Leu Uncertain significance Single submitter
- DNAJC11 p.Ser458Tyr Uncertain significance Single submitter
- DNAJC11 p.Thr238Ile Uncertain significance Single submitter
- DNAJC11 p.Thr504Met Uncertain significance Single submitter
- DNAJC11 p.Thr74Asn Uncertain significance Single submitter
- DNAJC11 p.Tyr142Cys Uncertain significance Single submitter
- DNAJC11 p.Val355Ala Uncertain significance Single submitter
- DNAJC11 p.Val394Met Uncertain significance Single submitter
All DNAJC11 variants
Benign 3
- p.Gly533= Multiple submitters
- p.Ser499= Multiple submitters
- c.1098-32dup Single submitter
Likely benign 1
- p.Met389Val Single submitter
Uncertain significance 59
- p.Ala198Val Single submitter ⚠
- p.Ala215Thr Single submitter ⚠
- p.Ala306Thr Single submitter ⚠
- p.Ala428Thr Single submitter ⚠
- p.Ala441Thr Single submitter ⚠
- p.Ala55Val Single submitter ⚠
- p.Arg229His Single submitter ⚠
- p.Arg248Cys Single submitter ⚠
- p.Arg345Gly Single submitter ⚠
- p.Arg405His Single submitter ⚠
- p.Arg554Lys Single submitter ⚠
- p.Asp143His Single submitter ⚠
- p.Asp318Asn Single submitter ⚠
- p.Asp71Glu Single submitter ⚠
- p.Gln311Glu Single submitter ⚠
- p.Gln433His Single submitter ⚠
- p.Glu105Gln Single submitter ⚠
- p.Glu29Asp Single submitter ⚠
- p.Glu29Val Single submitter ⚠
- p.Glu481Lys Single submitter ⚠
- p.Glu522Lys Single submitter ⚠
- p.Gly253Ser Single submitter ⚠
- p.Gly275Ser Single submitter ⚠
- p.Gly559Glu Single submitter ⚠
- p.Ile308Met Single submitter ⚠
- p.Ile453Asn Single submitter ⚠
- p.Ile453Thr Single submitter ⚠
- p.Leu10Val Single submitter ⚠
- p.Leu406Val Single submitter ⚠
- p.Leu528Val Single submitter ⚠
- p.Leu535Pro Single submitter ⚠
- p.Leu535Val Single submitter ⚠
- p.Lys206Glu Single submitter ⚠
- p.Lys342Thr Single submitter ⚠
- p.Lys418Gln Single submitter ⚠
- p.Lys435Gln Single submitter ⚠
- p.Lys471Asn Single submitter ⚠
- p.Met403Arg Single submitter ⚠
- p.Met403Val Single submitter ⚠
- p.Phe197Leu Single submitter ⚠
- p.Phe314Leu Single submitter ⚠
- p.Ser185Leu Single submitter ⚠
- p.Ser458Tyr Single submitter ⚠
- p.Thr238Ile Single submitter ⚠
- p.Thr504Met Single submitter ⚠
- p.Thr74Asn Single submitter ⚠
- p.Tyr142Cys Single submitter ⚠
- p.Tyr469Asn Single submitter ⚠
- p.Val285Ile Single submitter ⚠
- p.Val348Ile Single submitter ⚠
- p.Val355Ala Single submitter ⚠
- p.Val361Ile Single submitter ⚠
- p.Val394Met Single submitter ⚠
- p.Val465Ile Single submitter ⚠
- p.Val465Leu Single submitter ⚠
- p.Val473Ile Single submitter ⚠
- p.Val534Ile Single submitter ⚠
- p.Val538Met Single submitter ⚠
- p.Val93Ile Single submitter ⚠