DNAJC15 — 30 ClinVar variants
All ClinVar germline DNAJC15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
3 Likely benign · 27 Uncertain significance
Full DNAJC15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAJC15 p.Ala2Val Uncertain significance Single submitter
- DNAJC15 p.Ala3Ser Uncertain significance Single submitter
- DNAJC15 p.Ala3Thr Uncertain significance Single submitter
- DNAJC15 p.Ala3Val Uncertain significance Single submitter
- DNAJC15 p.Ala49Gly Uncertain significance Single submitter
- DNAJC15 p.Ala72Val Uncertain significance Single submitter
- DNAJC15 p.Ala8Pro Uncertain significance Single submitter
- DNAJC15 p.Asp28Gly Uncertain significance Single submitter
- DNAJC15 p.Gln34Leu Uncertain significance Single submitter
- DNAJC15 p.Gln66Arg Uncertain significance Single submitter
- DNAJC15 p.Glu12Gln Uncertain significance Single submitter
- DNAJC15 p.Gly44Glu Uncertain significance Single submitter
- DNAJC15 p.Gly54Asp Uncertain significance Single submitter
- DNAJC15 p.His150Arg Uncertain significance Single submitter
- DNAJC15 p.Leu14Phe Uncertain significance Single submitter
- DNAJC15 p.Phe88Val Uncertain significance Single submitter
- DNAJC15 p.Val133Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- DNAJC15 p.Ala49Val Uncertain significance Single submitter
- DNAJC15 p.Ala51Thr Uncertain significance Single submitter
- DNAJC15 p.Arg55His Uncertain significance Single submitter
- DNAJC15 p.Arg95Gln Uncertain significance Single submitter
- DNAJC15 p.His150Tyr Uncertain significance Single submitter
- DNAJC15 p.Ile112Val Uncertain significance Single submitter
- DNAJC15 p.Lys127Gln Uncertain significance Single submitter
- DNAJC15 p.Ser79Cys Uncertain significance Single submitter
- DNAJC15 p.Thr147Ile Uncertain significance Single submitter
- DNAJC15 p.Trp61Cys Uncertain significance Single submitter
- DNAJC15 p.Val103Ile Likely benign Single submitter
All DNAJC15 variants
Likely benign 3
- p.Ile7Val Single submitter
- p.Val103Ile Single submitter ⚠
- p.Val10Ala Single submitter
Uncertain significance 27
- p.Ala2Val Single submitter ⚠
- p.Ala3Ser Single submitter ⚠
- p.Ala3Thr Single submitter ⚠
- p.Ala3Val Single submitter ⚠
- p.Ala49Gly Single submitter ⚠
- p.Ala49Val Single submitter ⚠
- p.Ala51Thr Single submitter ⚠
- p.Ala72Val Single submitter ⚠
- p.Ala8Pro Single submitter ⚠
- p.Arg55His Single submitter ⚠
- p.Arg95Gln Single submitter ⚠
- p.Asp28Gly Single submitter ⚠
- p.Gln34Leu Single submitter ⚠
- p.Gln66Arg Single submitter ⚠
- p.Glu12Gln Single submitter ⚠
- p.Gly44Glu Single submitter ⚠
- p.Gly54Asp Single submitter ⚠
- p.His150Arg Single submitter ⚠
- p.His150Tyr Single submitter ⚠
- p.Ile112Val Single submitter ⚠
- p.Leu14Phe Single submitter ⚠
- p.Lys127Gln Single submitter ⚠
- p.Phe88Val Single submitter ⚠
- p.Ser79Cys Single submitter ⚠
- p.Thr147Ile Single submitter ⚠
- p.Trp61Cys Single submitter ⚠
- p.Val133Ile Single submitter ⚠