DNAJC18 — 48 ClinVar variants
All ClinVar germline DNAJC18 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
1 Likely benign · 47 Uncertain significance
Full DNAJC18 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAJC18 p.Arg103Thr Uncertain significance Single submitter
- DNAJC18 p.Arg141His Uncertain significance Single submitter
- DNAJC18 p.Asn161Thr Uncertain significance Single submitter
- DNAJC18 p.Asn22Lys Uncertain significance Single submitter
- DNAJC18 p.Asp284Glu Uncertain significance Single submitter
- DNAJC18 p.Cys115Tyr Uncertain significance Single submitter
- DNAJC18 p.Glu9Gln Uncertain significance Single submitter
- DNAJC18 p.Gly8Arg Uncertain significance Single submitter
- DNAJC18 p.His33Arg Uncertain significance Single submitter
- DNAJC18 p.Ile126Thr Uncertain significance Single submitter
- DNAJC18 p.Ile16Thr Uncertain significance Single submitter
- DNAJC18 p.Ile230Val Uncertain significance Single submitter
- DNAJC18 p.Ile352Thr Uncertain significance Single submitter
- DNAJC18 p.Leu98Phe Uncertain significance Single submitter
- DNAJC18 p.Lys23Glu Uncertain significance Single submitter
- DNAJC18 p.Lys48Asn Uncertain significance Single submitter
- DNAJC18 p.Lys48Glu Uncertain significance Single submitter
- DNAJC18 p.Met42Thr Uncertain significance Single submitter
- DNAJC18 p.Phe180Leu Uncertain significance Single submitter
- DNAJC18 p.Phe278Ser Uncertain significance Single submitter
- DNAJC18 p.Ser310Asn Uncertain significance Single submitter
- DNAJC18 p.Thr298Arg Uncertain significance Single submitter
- DNAJC18 p.Tyr145His Uncertain significance Single submitter
- DNAJC18 p.Tyr24Asn Uncertain significance Single submitter
- DNAJC18 p.Tyr84His Uncertain significance Single submitter
- DNAJC18 p.Val178Ile Uncertain significance Single submitter
- DNAJC18 p.Val275Leu Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- DNAJC18 p.Ala168Val Uncertain significance Single submitter
- DNAJC18 p.Arg141Cys Uncertain significance Single submitter
- DNAJC18 p.Arg203His Uncertain significance Single submitter
- DNAJC18 p.Arg205Gln Uncertain significance Single submitter
- DNAJC18 p.Arg207Gln Uncertain significance Single submitter
- DNAJC18 p.Arg210Lys Uncertain significance Single submitter
- DNAJC18 p.Arg355Cys Uncertain significance Single submitter
- DNAJC18 p.Arg355His Uncertain significance Single submitter
- DNAJC18 p.Arg91Gln Uncertain significance Single submitter
- DNAJC18 p.Arg91Gly Uncertain significance Single submitter
- DNAJC18 p.Asn135His Uncertain significance Single submitter
- DNAJC18 p.Asn177Ser Uncertain significance Single submitter
- DNAJC18 p.Asn194His Uncertain significance Single submitter
- DNAJC18 p.Asn272Tyr Uncertain significance Single submitter
- DNAJC18 p.Leu273Met Uncertain significance Single submitter
- DNAJC18 p.Met191Ile Uncertain significance Single submitter
- DNAJC18 p.Pro222Thr Uncertain significance Single submitter
- DNAJC18 p.Thr186Ile Uncertain significance Single submitter
- DNAJC18 p.Tyr163His Uncertain significance Single submitter
- DNAJC18 p.Tyr287His Uncertain significance Single submitter
All DNAJC18 variants
Likely benign 1
- p.Asn63Ser Single submitter
Uncertain significance 47
- p.Ala168Val Single submitter ⚠
- p.Arg103Thr Single submitter ⚠
- p.Arg141Cys Single submitter ⚠
- p.Arg141His Single submitter ⚠
- p.Arg203His Single submitter ⚠
- p.Arg205Gln Single submitter ⚠
- p.Arg207Gln Single submitter ⚠
- p.Arg210Lys Single submitter ⚠
- p.Arg355Cys Single submitter ⚠
- p.Arg355His Single submitter ⚠
- p.Arg91Gln Single submitter ⚠
- p.Arg91Gly Single submitter ⚠
- p.Asn135His Single submitter ⚠
- p.Asn161Thr Single submitter ⚠
- p.Asn177Ser Single submitter ⚠
- p.Asn194His Single submitter ⚠
- p.Asn22Lys Single submitter ⚠
- p.Asn272Tyr Single submitter ⚠
- p.Asp284Glu Single submitter ⚠
- p.Cys115Tyr Single submitter ⚠
- p.Glu9Gln Single submitter ⚠
- p.Gly8Arg Single submitter ⚠
- p.His33Arg Single submitter ⚠
- p.Ile126Thr Single submitter ⚠
- p.Ile16Thr Single submitter ⚠
- p.Ile230Val Single submitter ⚠
- p.Ile352Thr Single submitter ⚠
- p.Leu273Met Single submitter ⚠
- p.Leu98Phe Single submitter ⚠
- p.Lys23Glu Single submitter ⚠
- p.Lys48Asn Single submitter ⚠
- p.Lys48Glu Single submitter ⚠
- p.Met191Ile Single submitter ⚠
- p.Met42Thr Single submitter ⚠
- p.Phe180Leu Single submitter ⚠
- p.Phe278Ser Single submitter ⚠
- p.Pro222Thr Single submitter ⚠
- p.Ser310Asn Single submitter ⚠
- p.Thr186Ile Single submitter ⚠
- p.Thr298Arg Single submitter ⚠
- p.Tyr145His Single submitter ⚠
- p.Tyr163His Single submitter ⚠
- p.Tyr24Asn Single submitter ⚠
- p.Tyr287His Single submitter ⚠
- p.Tyr84His Single submitter ⚠
- p.Val178Ile Single submitter ⚠
- p.Val275Leu Single submitter ⚠