DNAJC22 — 59 ClinVar variants
All ClinVar germline DNAJC22 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
3 Likely benign · 56 Uncertain significance
Full DNAJC22 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAJC22 p.Ala171Pro Uncertain significance Single submitter
- DNAJC22 p.Ala206Val Uncertain significance Single submitter
- DNAJC22 p.Ala261Thr Uncertain significance Single submitter
- DNAJC22 p.Arg148Cys Uncertain significance Single submitter
- DNAJC22 p.Arg148Leu Uncertain significance Single submitter
- DNAJC22 p.Arg168His Uncertain significance Single submitter
- DNAJC22 p.Arg340Gln Uncertain significance Single submitter
- DNAJC22 p.Asn60Tyr Uncertain significance Single submitter
- DNAJC22 p.Gln258His Uncertain significance Single submitter
- DNAJC22 p.Glu249Gln Uncertain significance Single submitter
- DNAJC22 p.Gly147Asp Uncertain significance Single submitter
- DNAJC22 p.Gly16Asp Uncertain significance Single submitter
- DNAJC22 p.Gly251Ser Uncertain significance Single submitter
- DNAJC22 p.Gly39Arg Uncertain significance Single submitter
- DNAJC22 p.Gly88Asp Uncertain significance Single submitter
- DNAJC22 p.Gly92Val Uncertain significance Single submitter
- DNAJC22 p.Leu263Phe Uncertain significance Single submitter
- DNAJC22 p.Leu310Val Uncertain significance Single submitter
- DNAJC22 p.Lys132Glu Uncertain significance Single submitter
- DNAJC22 p.Lys51Glu Uncertain significance Single submitter
- DNAJC22 p.Met102Ile Uncertain significance Single submitter
- DNAJC22 p.Phe139Cys Uncertain significance Single submitter
- DNAJC22 p.Phe139Ile Uncertain significance Single submitter
- DNAJC22 p.Phe215Ser Uncertain significance Single submitter
- DNAJC22 p.Phe222Val Uncertain significance Single submitter
- DNAJC22 p.Phe225Ser Uncertain significance Single submitter
- DNAJC22 p.Tyr146Cys Uncertain significance Single submitter
- DNAJC22 p.Val14Leu Uncertain significance Single submitter
- DNAJC22 p.Val211Ala Uncertain significance Single submitter
- DNAJC22 p.Val301Ala Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- DNAJC22 p.Ala138Val Uncertain significance Single submitter
- DNAJC22 p.Ala159Ser Uncertain significance Single submitter
- DNAJC22 p.Ala278Val Uncertain significance Single submitter
- DNAJC22 p.Ala2Asp Uncertain significance Single submitter
- DNAJC22 p.Arg168Cys Uncertain significance Single submitter
- DNAJC22 p.Arg184Cys Uncertain significance Single submitter
- DNAJC22 p.Arg230Cys Uncertain significance Single submitter
- DNAJC22 p.Arg275His Uncertain significance Single submitter
- DNAJC22 p.Arg80Cys Uncertain significance Single submitter
- DNAJC22 p.Asn60Asp Uncertain significance Single submitter
- DNAJC22 p.Asp130Glu Uncertain significance Single submitter
- DNAJC22 p.Asp130His Uncertain significance Single submitter
- DNAJC22 p.Gly125Asp Uncertain significance Single submitter
- DNAJC22 p.Gly39Ala Uncertain significance Single submitter
- DNAJC22 p.Gly4Trp Uncertain significance Single submitter
- DNAJC22 p.Ile155Thr Uncertain significance Single submitter
- DNAJC22 p.Leu182Pro Uncertain significance Single submitter
- DNAJC22 p.Leu187Met Uncertain significance Single submitter
- DNAJC22 p.Lys302Asn Uncertain significance Single submitter
- DNAJC22 p.Lys3Thr Uncertain significance Single submitter
- DNAJC22 p.Pro177Leu Uncertain significance Single submitter
- DNAJC22 p.Pro333Ser Uncertain significance Single submitter
- DNAJC22 p.Pro53Gln Uncertain significance Single submitter
- DNAJC22 p.Ser54Asn Uncertain significance Single submitter
- DNAJC22 p.Ser77Gly Uncertain significance Single submitter
- DNAJC22 p.Ser98Arg Uncertain significance Single submitter
All DNAJC22 variants
Likely benign 3
- p.Arg295Gln Single submitter
- p.Gln298Arg Single submitter
- p.Val211= Single submitter
Uncertain significance 56
- p.Ala138Val Single submitter ⚠
- p.Ala159Ser Single submitter ⚠
- p.Ala171Pro Single submitter ⚠
- p.Ala206Val Single submitter ⚠
- p.Ala261Thr Single submitter ⚠
- p.Ala278Val Single submitter ⚠
- p.Ala2Asp Single submitter ⚠
- p.Arg148Cys Single submitter ⚠
- p.Arg148Leu Single submitter ⚠
- p.Arg168Cys Single submitter ⚠
- p.Arg168His Single submitter ⚠
- p.Arg184Cys Single submitter ⚠
- p.Arg230Cys Single submitter ⚠
- p.Arg275His Single submitter ⚠
- p.Arg340Gln Single submitter ⚠
- p.Arg80Cys Single submitter ⚠
- p.Asn60Asp Single submitter ⚠
- p.Asn60Tyr Single submitter ⚠
- p.Asp130Glu Single submitter ⚠
- p.Asp130His Single submitter ⚠
- p.Gln258His Single submitter ⚠
- p.Glu249Gln Single submitter ⚠
- p.Gly125Asp Single submitter ⚠
- p.Gly147Asp Single submitter ⚠
- p.Gly16Asp Single submitter ⚠
- p.Gly251Ser Single submitter ⚠
- p.Gly39Ala Single submitter ⚠
- p.Gly39Arg Single submitter ⚠
- p.Gly4Trp Single submitter ⚠
- p.Gly88Asp Single submitter ⚠
- p.Gly92Val Single submitter ⚠
- p.Ile155Thr Single submitter ⚠
- p.Leu182Pro Single submitter ⚠
- p.Leu187Met Single submitter ⚠
- p.Leu263Phe Single submitter ⚠
- p.Leu310Val Single submitter ⚠
- p.Lys132Glu Single submitter ⚠
- p.Lys302Asn Single submitter ⚠
- p.Lys3Thr Single submitter ⚠
- p.Lys51Glu Single submitter ⚠
- p.Met102Ile Single submitter ⚠
- p.Phe139Cys Single submitter ⚠
- p.Phe139Ile Single submitter ⚠
- p.Phe215Ser Single submitter ⚠
- p.Phe222Val Single submitter ⚠
- p.Phe225Ser Single submitter ⚠
- p.Pro177Leu Single submitter ⚠
- p.Pro333Ser Single submitter ⚠
- p.Pro53Gln Single submitter ⚠
- p.Ser54Asn Single submitter ⚠
- p.Ser77Gly Single submitter ⚠
- p.Ser98Arg Single submitter ⚠
- p.Tyr146Cys Single submitter ⚠
- p.Val14Leu Single submitter ⚠
- p.Val211Ala Single submitter ⚠
- p.Val301Ala Single submitter ⚠