DNAJC25 — 15 ClinVar variants
All ClinVar germline DNAJC25 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 15 flagged for review →
15 Uncertain significance
Full DNAJC25 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 15
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAJC25 p.Arg117Gly Uncertain significance Single submitter
- DNAJC25 p.Arg265Gln Uncertain significance Single submitter
- DNAJC25 p.Arg354Trp Uncertain significance Single submitter
- DNAJC25 p.Asp119Tyr Uncertain significance Single submitter
- DNAJC25 p.Gln296Arg Uncertain significance Single submitter
- DNAJC25 p.Glu301Lys Uncertain significance Single submitter
- DNAJC25 p.Lys173Gln Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- DNAJC25 p.Arg141His Uncertain significance Single submitter
- DNAJC25 p.Arg265Trp Uncertain significance Single submitter
- DNAJC25 p.Arg311Gly Uncertain significance Single submitter
- DNAJC25 p.Asp360Gly Uncertain significance Single submitter
- DNAJC25 p.Glu212Gly Uncertain significance Single submitter
- DNAJC25 p.Lys275Glu Uncertain significance Single submitter
- DNAJC25 p.Trp168Arg Uncertain significance Single submitter
- DNAJC25 p.Trp346Arg Uncertain significance Single submitter
All DNAJC25 variants
Uncertain significance 15
- p.Arg117Gly Single submitter ⚠
- p.Arg141His Single submitter ⚠
- p.Arg265Gln Single submitter ⚠
- p.Arg265Trp Single submitter ⚠
- p.Arg311Gly Single submitter ⚠
- p.Arg354Trp Single submitter ⚠
- p.Asp119Tyr Single submitter ⚠
- p.Asp360Gly Single submitter ⚠
- p.Gln296Arg Single submitter ⚠
- p.Glu212Gly Single submitter ⚠
- p.Glu301Lys Single submitter ⚠
- p.Lys173Gln Single submitter ⚠
- p.Lys275Glu Single submitter ⚠
- p.Trp168Arg Single submitter ⚠
- p.Trp346Arg Single submitter ⚠