DNPEP — 83 ClinVar variants
All ClinVar germline DNPEP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 80 flagged for review →
2 Benign · 2 Likely benign · 79 Uncertain significance
Full DNPEP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 80
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNPEP p.Ala204Thr Uncertain significance Single submitter
- DNPEP p.Ala221Thr Uncertain significance Single submitter
- DNPEP p.Ala27Val Uncertain significance Single submitter
- DNPEP p.Arg114His Uncertain significance Single submitter
- DNPEP p.Arg114Leu Uncertain significance Single submitter
- DNPEP p.Arg142Cys Uncertain significance Single submitter
- DNPEP p.Arg159Gln Uncertain significance Single submitter
- DNPEP p.Arg169Pro Uncertain significance Single submitter
- DNPEP p.Arg272Trp Uncertain significance Single submitter
- DNPEP p.Arg332Leu Uncertain significance Single submitter
- DNPEP p.Arg434Gln Uncertain significance Single submitter
- DNPEP p.Asn275Ser Uncertain significance Single submitter
- DNPEP p.Asn36Lys Uncertain significance Single submitter
- DNPEP p.Asn67Ser Uncertain significance Single submitter
- DNPEP p.Asp265Asn Uncertain significance Single submitter
- DNPEP p.Asp309Gly Uncertain significance Single submitter
- DNPEP p.Gln12Arg Uncertain significance Single submitter
- DNPEP p.Gln25Lys Uncertain significance Single submitter
- DNPEP p.Gln54Arg Uncertain significance Single submitter
- DNPEP p.Glu311Lys Uncertain significance Single submitter
- DNPEP p.Glu71Gln Uncertain significance Single submitter
- DNPEP p.Gly134Val Uncertain significance Single submitter
- DNPEP p.Gly148Glu Uncertain significance Single submitter
- DNPEP p.Gly190Val Uncertain significance Single submitter
- DNPEP p.Gly314Arg Uncertain significance Single submitter
- DNPEP p.Gly314Val Uncertain significance Single submitter
- DNPEP p.Gly9Arg Uncertain significance Single submitter
- DNPEP p.His180Leu Uncertain significance Single submitter
- DNPEP p.His227Asn Uncertain significance Single submitter
- DNPEP p.Leu483Ser Uncertain significance Single submitter
- DNPEP p.Lys153Arg Uncertain significance Single submitter
- DNPEP p.Met15Val Uncertain significance Single submitter
- DNPEP p.Phe472Ser Uncertain significance Single submitter
- DNPEP p.Phe57Leu Uncertain significance Single submitter
- DNPEP p.Phe75Leu Uncertain significance Single submitter
- DNPEP p.Phe75Ser Uncertain significance Single submitter
- DNPEP p.Pro214Ser Uncertain significance Single submitter
- DNPEP p.Pro429Leu Uncertain significance Single submitter
- DNPEP p.Thr138Ile Uncertain significance Single submitter
- DNPEP p.Thr145Ile Uncertain significance Single submitter
- DNPEP p.Thr82Ile Uncertain significance Single submitter
- DNPEP p.Trp139Cys Uncertain significance Single submitter
- DNPEP p.Tyr308Cys Uncertain significance Single submitter
- DNPEP p.Tyr391Cys Uncertain significance Single submitter
- DNPEP p.Val150Ala Uncertain significance Single submitter
- DNPEP p.Val24Met Uncertain significance Single submitter
- DNPEP p.Val461Ile Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- DNPEP p.Ala263Ser Uncertain significance Single submitter
- DNPEP p.Ala321Ser Uncertain significance Single submitter
- DNPEP p.Arg117His Uncertain significance Single submitter
- DNPEP p.Arg149Cys Uncertain significance Single submitter
- DNPEP p.Arg149His Uncertain significance Single submitter
- DNPEP p.Arg169Gln Uncertain significance Single submitter
- DNPEP p.Arg183Gln Likely benign Single submitter
- DNPEP p.Arg20Cys Uncertain significance Single submitter
- DNPEP p.Arg303Cys Uncertain significance Single submitter
- DNPEP p.Arg303His Uncertain significance Single submitter
- DNPEP p.Arg374Trp Uncertain significance Single submitter
- DNPEP p.Arg390Cys Uncertain significance Single submitter
- DNPEP p.Arg390His Uncertain significance Single submitter
- DNPEP p.Arg402Gln Uncertain significance Single submitter
- DNPEP p.Arg438Gln Uncertain significance Single submitter
- DNPEP p.Arg51Ser Uncertain significance Single submitter
- DNPEP p.Asn186Ser Uncertain significance Single submitter
- DNPEP p.Asp485Tyr Uncertain significance Single submitter
- DNPEP p.Gln322Pro Uncertain significance Single submitter
- DNPEP p.Glu161Asp Uncertain significance Single submitter
- DNPEP p.Gly127Ser Uncertain significance Single submitter
- DNPEP p.His166Tyr Uncertain significance Single submitter
- DNPEP p.Ile245Thr Uncertain significance Single submitter
- DNPEP p.Leu260Phe Uncertain significance Single submitter
- DNPEP p.Pro155Ser Uncertain significance Single submitter
- DNPEP p.Pro175Ala Uncertain significance Single submitter
- DNPEP p.Pro41Thr Uncertain significance Single submitter
- DNPEP p.Ser336Leu Uncertain significance Single submitter
- DNPEP p.Ser387Arg Uncertain significance Single submitter
- DNPEP p.Thr341Ile Uncertain significance Single submitter
- DNPEP p.Val150Ile Uncertain significance Single submitter
- DNPEP p.Val35Met Uncertain significance Single submitter
- DNPEP p.Val361Met Uncertain significance Single submitter
All DNPEP variants
Benign 2
- p.Ile171Val Multiple submitters
- c.937-6C>T Single submitter
Likely benign 2
- p.Arg183Gln Single submitter ⚠
- p.Asn50Ser Single submitter
Uncertain significance 79
- p.Ala204Thr Single submitter ⚠
- p.Ala221Thr Single submitter ⚠
- p.Ala263Ser Single submitter ⚠
- p.Ala27Val Single submitter ⚠
- p.Ala321Ser Single submitter ⚠
- p.Arg114His Single submitter ⚠
- p.Arg114Leu Single submitter ⚠
- p.Arg117His Single submitter ⚠
- p.Arg142Cys Single submitter ⚠
- p.Arg149Cys Single submitter ⚠
- p.Arg149His Single submitter ⚠
- p.Arg159Gln Single submitter ⚠
- p.Arg169Gln Single submitter ⚠
- p.Arg169Pro Single submitter ⚠
- p.Arg20Cys Single submitter ⚠
- p.Arg272Trp Single submitter ⚠
- p.Arg303Cys Single submitter ⚠
- p.Arg303His Single submitter ⚠
- p.Arg332Leu Single submitter ⚠
- p.Arg374Trp Single submitter ⚠
- p.Arg390Cys Single submitter ⚠
- p.Arg390His Single submitter ⚠
- p.Arg402Gln Single submitter ⚠
- p.Arg434Gln Single submitter ⚠
- p.Arg438Gln Single submitter ⚠
- p.Arg51Ser Single submitter ⚠
- p.Asn186Ser Single submitter ⚠
- p.Asn275Ser Single submitter ⚠
- p.Asn36Lys Single submitter ⚠
- p.Asn67Ser Single submitter ⚠
- p.Asp265Asn Single submitter ⚠
- p.Asp309Gly Single submitter ⚠
- p.Asp485Tyr Single submitter ⚠
- p.Gln12Arg Single submitter ⚠
- p.Gln25Lys Single submitter ⚠
- p.Gln322Pro Single submitter ⚠
- p.Gln54Arg Single submitter ⚠
- p.Glu161Asp Single submitter ⚠
- p.Glu311Lys Single submitter ⚠
- p.Glu71Gln Single submitter ⚠
- p.Gly127Ser Single submitter ⚠
- p.Gly134Val Single submitter ⚠
- p.Gly148Glu Single submitter ⚠
- p.Gly190Val Single submitter ⚠
- p.Gly314Arg Single submitter ⚠
- p.Gly314Val Single submitter ⚠
- p.Gly9Arg Single submitter ⚠
- p.His166Tyr Single submitter ⚠
- p.His180Leu Single submitter ⚠
- p.His227Asn Single submitter ⚠
- p.Ile245Thr Single submitter ⚠
- p.Leu260Phe Single submitter ⚠
- p.Leu483Ser Single submitter ⚠
- p.Lys153Arg Single submitter ⚠
- p.Met15Val Single submitter ⚠
- p.Phe472Ser Single submitter ⚠
- p.Phe57Leu Single submitter ⚠
- p.Phe75Leu Single submitter ⚠
- p.Phe75Ser Single submitter ⚠
- p.Pro155Ser Single submitter ⚠
- p.Pro175Ala Single submitter ⚠
- p.Pro214Ser Single submitter ⚠
- p.Pro41Thr Single submitter ⚠
- p.Pro429Leu Single submitter ⚠
- p.Ser336Leu Single submitter ⚠
- p.Ser387Arg Single submitter ⚠
- p.Thr138Ile Single submitter ⚠
- p.Thr145Ile Single submitter ⚠
- p.Thr341Ile Single submitter ⚠
- p.Thr82Ile Single submitter ⚠
- p.Trp139Cys Single submitter ⚠
- p.Tyr308Cys Single submitter ⚠
- p.Tyr391Cys Single submitter ⚠
- p.Val150Ala Single submitter ⚠
- p.Val150Ile Single submitter ⚠
- p.Val24Met Single submitter ⚠
- p.Val35Met Single submitter ⚠
- p.Val361Met Single submitter ⚠
- p.Val461Ile Single submitter ⚠