DNTTIP2 — 101 ClinVar variants
All ClinVar germline DNTTIP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 96 flagged for review →
6 Likely benign · 95 Uncertain significance
Full DNTTIP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 96
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 62
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNTTIP2 p.Ala347Val Uncertain significance Single submitter
- DNTTIP2 p.Ala358Pro Uncertain significance Single submitter
- DNTTIP2 p.Ala43Ser Uncertain significance Single submitter
- DNTTIP2 p.Ala43Thr Uncertain significance Single submitter
- DNTTIP2 p.Ala43Val Uncertain significance Single submitter
- DNTTIP2 p.Ala511Val Uncertain significance Single submitter
- DNTTIP2 p.Ala64Gly Uncertain significance Single submitter
- DNTTIP2 p.Arg208Thr Uncertain significance Single submitter
- DNTTIP2 p.Arg250Ile Uncertain significance Single submitter
- DNTTIP2 p.Arg374Ile Uncertain significance Single submitter
- DNTTIP2 p.Arg637Gln Uncertain significance Single submitter
- DNTTIP2 p.Arg70Ser Uncertain significance Single submitter
- DNTTIP2 p.Asn259Asp Uncertain significance Single submitter
- DNTTIP2 p.Asn262Asp Uncertain significance Single submitter
- DNTTIP2 p.Asn346His Uncertain significance Single submitter
- DNTTIP2 p.Asn455Ile Uncertain significance Single submitter
- DNTTIP2 p.Asn502Thr Uncertain significance Single submitter
- DNTTIP2 p.Asp173Gly Uncertain significance Single submitter
- DNTTIP2 p.Asp398Asn Uncertain significance Single submitter
- DNTTIP2 p.Cys394Phe Uncertain significance Single submitter
- DNTTIP2 p.Gln337Arg Uncertain significance Single submitter
- DNTTIP2 p.Glu282Gln Uncertain significance Single submitter
- DNTTIP2 p.Glu508Asp Uncertain significance Single submitter
- DNTTIP2 p.Glu98Lys Uncertain significance Single submitter
- DNTTIP2 p.Gly647Ala Uncertain significance Single submitter
- DNTTIP2 p.His281Leu Uncertain significance Single submitter
- DNTTIP2 p.His351Asn Uncertain significance Single submitter
- DNTTIP2 p.Ile193Val Uncertain significance Single submitter
- DNTTIP2 p.Ile306Thr Uncertain significance Single submitter
- DNTTIP2 p.Ile31Phe Uncertain significance Single submitter
- DNTTIP2 p.Ile406Thr Uncertain significance Single submitter
- DNTTIP2 p.Ile693Val Uncertain significance Single submitter
- DNTTIP2 p.Leu326Phe Uncertain significance Single submitter
- DNTTIP2 p.Lys216Arg Uncertain significance Single submitter
- DNTTIP2 p.Lys227Arg Uncertain significance Single submitter
- DNTTIP2 p.Lys24Arg Uncertain significance Single submitter
- DNTTIP2 p.Lys510Arg Uncertain significance Single submitter
- DNTTIP2 p.Lys553Glu Uncertain significance Single submitter
- DNTTIP2 p.Lys589Arg Uncertain significance Single submitter
- DNTTIP2 p.Lys649Thr Uncertain significance Single submitter
- DNTTIP2 p.Lys665Glu Uncertain significance Single submitter
- DNTTIP2 p.Met206Val Uncertain significance Single submitter
- DNTTIP2 p.Met412Thr Uncertain significance Single submitter
- DNTTIP2 p.Phe195Ser Uncertain significance Single submitter
- DNTTIP2 p.Pro431Ser Uncertain significance Single submitter
- DNTTIP2 p.Pro495Thr Uncertain significance Single submitter
- DNTTIP2 p.Pro620Ser Uncertain significance Single submitter
- DNTTIP2 p.Pro62Ala Uncertain significance Single submitter
- DNTTIP2 p.Pro697Ser Uncertain significance Single submitter
- DNTTIP2 p.Ser12Arg Uncertain significance Single submitter
- DNTTIP2 p.Ser447Gly Uncertain significance Single submitter
- DNTTIP2 p.Ser74Leu Uncertain significance Single submitter
- DNTTIP2 p.Thr129Ser Uncertain significance Single submitter
- DNTTIP2 p.Thr200Ala Uncertain significance Single submitter
- DNTTIP2 p.Thr200Pro Uncertain significance Single submitter
- DNTTIP2 p.Thr479Ala Uncertain significance Single submitter
- DNTTIP2 p.Thr654Arg Uncertain significance Single submitter
- DNTTIP2 p.Thr71Asn Uncertain significance Single submitter
- DNTTIP2 p.Val335Ile Uncertain significance Single submitter
- DNTTIP2 p.Val441Asp Uncertain significance Single submitter
- DNTTIP2 p.Val441Ile Uncertain significance Single submitter
- DNTTIP2 p.Val608Asp Uncertain significance Single submitter
Predictors split 34
The independent predictors disagree with each other — read with care.
- DNTTIP2 p.Ala11Thr Uncertain significance Single submitter
- DNTTIP2 p.Ala554Val Uncertain significance Single submitter
- DNTTIP2 p.Arg633His Uncertain significance Single submitter
- DNTTIP2 p.Asn29His Uncertain significance Single submitter
- DNTTIP2 p.Asn659Lys Uncertain significance Single submitter
- DNTTIP2 p.Asp218Tyr Uncertain significance Single submitter
- DNTTIP2 p.Asp461Val Uncertain significance Single submitter
- DNTTIP2 p.Asp485His Uncertain significance Single submitter
- DNTTIP2 p.Glu459Lys Uncertain significance Single submitter
- DNTTIP2 p.Glu526Lys Uncertain significance Single submitter
- DNTTIP2 p.Glu537Lys Uncertain significance Single submitter
- DNTTIP2 p.Glu597Ala Uncertain significance Single submitter
- DNTTIP2 p.Gly574Asp Uncertain significance Single submitter
- DNTTIP2 p.Gly683Ser Uncertain significance Single submitter
- DNTTIP2 p.Leu445Arg Uncertain significance Single submitter
- DNTTIP2 p.Lys66Glu Uncertain significance Single submitter
- DNTTIP2 p.Met653Val Uncertain significance Single submitter
- DNTTIP2 p.Ser121Gly Uncertain significance Single submitter
- DNTTIP2 p.Ser194Ala Uncertain significance Single submitter
- DNTTIP2 p.Ser205Gly Uncertain significance Single submitter
- DNTTIP2 p.Ser270Phe Likely benign Single submitter
- DNTTIP2 p.Ser352Phe Uncertain significance Single submitter
- DNTTIP2 p.Ser381Gly Uncertain significance Single submitter
- DNTTIP2 p.Ser397Gly Uncertain significance Single submitter
- DNTTIP2 p.Ser446Arg Uncertain significance Single submitter
- DNTTIP2 p.Ser450Asn Uncertain significance Single submitter
- DNTTIP2 p.Ser512Cys Uncertain significance Single submitter
- DNTTIP2 p.Ser563Ile Uncertain significance Single submitter
- DNTTIP2 p.Ser722Cys Uncertain significance Single submitter
- DNTTIP2 p.Thr341Ala Uncertain significance Single submitter
- DNTTIP2 p.Thr39Ile Uncertain significance Single submitter
- DNTTIP2 p.Thr552Ile Uncertain significance Single submitter
- DNTTIP2 p.Thr83Met Uncertain significance Single submitter
- DNTTIP2 p.Val694Leu Uncertain significance Single submitter
All DNTTIP2 variants
Likely benign 6
- p.Asn285Ser Single submitter
- p.Glu282Lys Single submitter
- p.Lys379Arg Single submitter
- p.Phe26Ser Single submitter
- p.Ser270Phe Single submitter ⚠
- p.Val608Ile Single submitter
Uncertain significance 95
- p.Ala11Thr Single submitter ⚠
- p.Ala347Val Single submitter ⚠
- p.Ala358Pro Single submitter ⚠
- p.Ala43Ser Single submitter ⚠
- p.Ala43Thr Single submitter ⚠
- p.Ala43Val Single submitter ⚠
- p.Ala511Val Single submitter ⚠
- p.Ala554Val Single submitter ⚠
- p.Ala64Gly Single submitter ⚠
- p.Arg208Thr Single submitter ⚠
- p.Arg250Ile Single submitter ⚠
- p.Arg374Ile Single submitter ⚠
- p.Arg633His Single submitter ⚠
- p.Arg637Gln Single submitter ⚠
- p.Arg70Ser Single submitter ⚠
- p.Asn259Asp Single submitter ⚠
- p.Asn262Asp Single submitter ⚠
- p.Asn29His Single submitter ⚠
- p.Asn346His Single submitter ⚠
- p.Asn455Ile Single submitter ⚠
- p.Asn502Thr Single submitter ⚠
- p.Asn659Lys Single submitter ⚠
- p.Asp173Gly Single submitter ⚠
- p.Asp218Tyr Single submitter ⚠
- p.Asp398Asn Single submitter ⚠
- p.Asp461Val Single submitter ⚠
- p.Asp485His Single submitter ⚠
- p.Cys394Phe Single submitter ⚠
- p.Gln337Arg Single submitter ⚠
- p.Glu282Gln Single submitter ⚠
- p.Glu459Lys Single submitter ⚠
- p.Glu508Asp Single submitter ⚠
- p.Glu526Lys Single submitter ⚠
- p.Glu537Lys Single submitter ⚠
- p.Glu597Ala Single submitter ⚠
- p.Glu98Lys Single submitter ⚠
- p.Gly574Asp Single submitter ⚠
- p.Gly647Ala Single submitter ⚠
- p.Gly683Ser Single submitter ⚠
- p.His281Leu Single submitter ⚠
- p.His351Asn Single submitter ⚠
- p.Ile193Val Single submitter ⚠
- p.Ile306Thr Single submitter ⚠
- p.Ile31Phe Single submitter ⚠
- p.Ile406Thr Single submitter ⚠
- p.Ile693Val Single submitter ⚠
- p.Leu326Phe Single submitter ⚠
- p.Leu445Arg Single submitter ⚠
- p.Lys216Arg Single submitter ⚠
- p.Lys227Arg Single submitter ⚠
- p.Lys24Arg Single submitter ⚠
- p.Lys510Arg Single submitter ⚠
- p.Lys553Glu Single submitter ⚠
- p.Lys589Arg Single submitter ⚠
- p.Lys649Thr Single submitter ⚠
- p.Lys665Glu Single submitter ⚠
- p.Lys66Glu Single submitter ⚠
- p.Met206Val Single submitter ⚠
- p.Met412Thr Single submitter ⚠
- p.Met653Val Single submitter ⚠
- p.Phe195Ser Single submitter ⚠
- p.Pro431Ser Single submitter ⚠
- p.Pro495Thr Single submitter ⚠
- p.Pro620Ser Single submitter ⚠
- p.Pro62Ala Single submitter ⚠
- p.Pro697Ser Single submitter ⚠
- p.Ser121Gly Single submitter ⚠
- p.Ser12Arg Single submitter ⚠
- p.Ser194Ala Single submitter ⚠
- p.Ser205Gly Single submitter ⚠
- p.Ser352Phe Single submitter ⚠
- p.Ser381Gly Single submitter ⚠
- p.Ser397Gly Single submitter ⚠
- p.Ser446Arg Single submitter ⚠
- p.Ser447Gly Single submitter ⚠
- p.Ser450Asn Single submitter ⚠
- p.Ser512Cys Single submitter ⚠
- p.Ser563Ile Single submitter ⚠
- p.Ser722Cys Single submitter ⚠
- p.Ser74Leu Single submitter ⚠
- p.Thr129Ser Single submitter ⚠
- p.Thr200Ala Single submitter ⚠
- p.Thr200Pro Single submitter ⚠
- p.Thr341Ala Single submitter ⚠
- p.Thr39Ile Single submitter ⚠
- p.Thr479Ala Single submitter ⚠
- p.Thr552Ile Single submitter ⚠
- p.Thr654Arg Single submitter ⚠
- p.Thr71Asn Single submitter ⚠
- p.Thr83Met Single submitter ⚠
- p.Val335Ile Single submitter ⚠
- p.Val441Asp Single submitter ⚠
- p.Val441Ile Single submitter ⚠
- p.Val608Asp Single submitter ⚠
- p.Val694Leu Single submitter ⚠