DOCK10 — 280 ClinVar variants

All ClinVar germline DOCK10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 267 flagged for review →

1 Conflicting · 5 Benign · 9 Likely benign · 265 Uncertain significance

Full DOCK10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 267

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

DOCK10 p.Arg301Lys Conflicting Single submitter

Predictors lean, ClinVar uncertain 167

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 167

Predictors split 99

The independent predictors disagree with each other — read with care.

All DOCK10 variants

Conflicting classifications of pathogenicity 1

p.Arg301Lys Single submitter ⚠

Benign 5

p.Asp2034= Multiple submitters
p.Ser1349= Multiple submitters
p.Thr1950= Multiple submitters
c.4394-4A>G Single submitter
p.Glu320Asp Single submitter

Likely benign 9

p.Arg65Gln Single submitter
p.Arg956Thr Single submitter
p.Asp1373= Single submitter
p.Gly2151Cys Single submitter
p.Ile2180Val Single submitter
p.Leu483Phe Single submitter
p.Ser548Gly Single submitter
p.Val2144Ile Single submitter
p.Val850Leu Single submitter ⚠

Uncertain significance 265

p.Ala112Ser Single submitter ⚠
p.Ala1135Thr Single submitter ⚠
p.Ala1175Thr Single submitter ⚠
p.Ala1177Ser Single submitter ⚠
p.Ala1271Glu Single submitter ⚠
p.Ala1284Thr Single submitter ⚠
p.Ala1355Val Single submitter ⚠
p.Ala1534Val Single submitter ⚠
p.Ala1621Thr Single submitter ⚠
p.Ala1639Pro Single submitter ⚠
p.Ala1639Thr Single submitter ⚠
p.Ala1693Thr Single submitter ⚠
p.Ala19Val Single submitter ⚠
p.Ala2079Asp Single submitter ⚠
p.Ala2107Thr Single submitter ⚠
p.Ala2174Gly Single submitter ⚠
p.Ala257Val Single submitter ⚠
p.Ala27Thr Single submitter ⚠
p.Ala29Thr Single submitter ⚠
p.Ala31Glu Single submitter ⚠
p.Ala31Thr Single submitter ⚠
p.Ala523Thr Single submitter ⚠
p.Ala729Thr Single submitter ⚠
p.Ala777Thr Single submitter ⚠
p.Ala782Ser Single submitter ⚠
p.Arg1062His Single submitter ⚠
p.Arg1149Cys Single submitter ⚠
p.Arg1149His Single submitter ⚠
p.Arg1159Gln Single submitter ⚠
p.Arg1191Gln Single submitter ⚠
p.Arg1325Gln Single submitter ⚠
p.Arg135Gln Single submitter ⚠
p.Arg1385Cys Single submitter ⚠
p.Arg1385His Single submitter ⚠
p.Arg1577Gln Single submitter ⚠
p.Arg1627Trp Single submitter ⚠
p.Arg1660His Single submitter ⚠
p.Arg1844Gln Single submitter ⚠
p.Arg1858Gln Single submitter ⚠
p.Arg1876His Single submitter ⚠
p.Arg1964Gln Single submitter ⚠
p.Arg1976His Single submitter ⚠
p.Arg1976Ser Single submitter ⚠
p.Arg204Trp Single submitter ⚠
p.Arg2078Gln Single submitter ⚠
p.Arg2078Gly Single submitter ⚠
p.Arg209Cys Single submitter ⚠
p.Arg2117His Single submitter ⚠
p.Arg2158His Single submitter ⚠
p.Arg254Lys Single submitter ⚠
p.Arg287Cys Single submitter ⚠
p.Arg287His Single submitter ⚠
p.Arg352Gln Single submitter ⚠
p.Arg41Pro Single submitter ⚠
p.Arg473Ser Single submitter ⚠
p.Arg65Trp Single submitter ⚠
p.Arg666Leu Single submitter ⚠
p.Arg884Cys Single submitter ⚠
p.Asn1077Ser Single submitter ⚠
p.Asn1230Asp Single submitter ⚠
p.Asn1805Lys Single submitter ⚠
p.Asn192Ser Single submitter ⚠
p.Asn1933Lys Single submitter ⚠
p.Asn1936Ser Single submitter ⚠
p.Asn704Ser Single submitter ⚠
p.Asp1265His Single submitter ⚠
p.Asp1308Asn Single submitter ⚠
p.Asp1373Asn Single submitter ⚠
p.Asp1373Glu Single submitter ⚠
p.Asp1460His Single submitter ⚠
p.Asp1656Glu Single submitter ⚠
p.Asp1851Asn Single submitter ⚠
p.Asp2136Val Single submitter ⚠
p.Asp2154Val Single submitter ⚠
p.Asp52Gly Single submitter ⚠
p.Asp600Glu Single submitter ⚠
p.Asp931Asn Single submitter ⚠
p.Cys1103Gly Single submitter ⚠
p.Cys1508Arg Single submitter ⚠
p.Cys1547Arg Single submitter ⚠
p.Cys2108Gly Single submitter ⚠
p.Cys2164Arg Single submitter ⚠
p.Cys238Ser Single submitter ⚠
p.Cys665Tyr Single submitter ⚠
p.Cys715Arg Single submitter ⚠
p.Cys715Tyr Single submitter ⚠
p.Gln1166Lys Single submitter ⚠
p.Gln1457Lys Single submitter ⚠
p.Gln1507Glu Single submitter ⚠
p.Gln2093Glu Single submitter ⚠
p.Gln249Lys Single submitter ⚠
p.Gln453Lys Single submitter ⚠
p.Gln453Pro Single submitter ⚠
p.Gln584Lys Single submitter ⚠
p.Gln738His Single submitter ⚠
p.Glu1021Ala Single submitter ⚠
p.Glu1132Lys Single submitter ⚠
p.Glu1140Lys Single submitter ⚠
p.Glu1194Lys Single submitter ⚠
p.Glu1301Gly Single submitter ⚠
p.Glu1679Gln Single submitter ⚠
p.Glu1732Lys Single submitter ⚠
p.Glu1962Lys Single submitter ⚠
p.Glu2128Ala Single submitter ⚠
p.Glu2140Lys Single submitter ⚠
p.Glu380Lys Single submitter ⚠
p.Glu411Asp Single submitter ⚠
p.Glu512Lys Single submitter ⚠
p.Glu707Lys Single submitter ⚠
p.Glu866Asp Single submitter ⚠
p.Glu938Gly Single submitter ⚠
p.Gly1432Asp Single submitter ⚠
p.Gly1625Asp Single submitter ⚠
p.Gly173Ala Single submitter ⚠
p.Gly173Glu Single submitter ⚠
p.Gly173Val Single submitter ⚠
p.Gly174Val Single submitter ⚠
p.Gly178Glu Single submitter ⚠
p.Gly179Glu Single submitter ⚠
p.Gly1893Ser Single submitter ⚠
p.Gly1987Ser Single submitter ⚠
p.Gly309Cys Single submitter ⚠
p.His121Gln Single submitter ⚠
p.His1430Leu Single submitter ⚠
p.His1433Arg Single submitter ⚠
p.His156Arg Single submitter ⚠
p.His24Arg Single submitter ⚠
p.His334Arg Single submitter ⚠
p.His334Gln Single submitter ⚠
p.His448Arg Single submitter ⚠
p.His758Tyr Single submitter ⚠
p.His797Tyr Single submitter ⚠
p.His828Arg Single submitter ⚠
p.His896Gln Single submitter ⚠
p.His989Asp Single submitter ⚠
p.Ile1011Leu Single submitter ⚠
p.Ile1154Met Single submitter ⚠
p.Ile1156Phe Single submitter ⚠
p.Ile1276Thr Single submitter ⚠
p.Ile1344Val Single submitter ⚠
p.Ile134Phe Single submitter ⚠
p.Ile1470Val Single submitter ⚠
p.Ile154Thr Single submitter ⚠
p.Ile1661Met Single submitter ⚠
p.Ile1724Asn Single submitter ⚠
p.Ile1724Thr Single submitter ⚠
p.Ile1837Thr Single submitter ⚠
p.Ile2019Phe Single submitter ⚠
p.Ile2168Val Single submitter ⚠
p.Ile383Val Single submitter ⚠
p.Ile519Val Single submitter ⚠
p.Ile809Thr Single submitter ⚠
p.Ile89Ser Single submitter ⚠
p.Ile997Thr Single submitter ⚠
p.Leu1267Ser Single submitter ⚠
p.Leu1763Phe Single submitter ⚠
p.Leu1781Trp Single submitter ⚠
p.Leu1985Arg Single submitter ⚠
p.Leu2096Phe Single submitter ⚠
p.Leu310Pro Single submitter ⚠
p.Leu376Arg Single submitter ⚠
p.Leu401Phe Single submitter ⚠
p.Leu488Pro Single submitter ⚠
p.Leu515Ser Single submitter ⚠
p.Leu724Phe Single submitter ⚠
p.Leu73Met Single submitter ⚠
p.Lys103Arg Single submitter ⚠
p.Lys2098Glu Single submitter ⚠
p.Lys339Glu Single submitter ⚠
p.Lys399Glu Single submitter ⚠
p.Lys566Glu Single submitter ⚠
p.Lys680Asn Single submitter ⚠
p.Lys692Thr Single submitter ⚠
p.Lys747Glu Single submitter ⚠
p.Lys911Arg Single submitter ⚠
p.Lys988Met Single submitter ⚠
p.Met1001Val Single submitter ⚠
p.Met1211Val Single submitter ⚠
p.Met1216Thr Single submitter ⚠
p.Met1671Arg Single submitter ⚠
p.Met1772Thr Single submitter ⚠
p.Met2074Ile Single submitter ⚠
p.Met2145Val Single submitter ⚠
p.Met223Ile Single submitter ⚠
p.Met278Val Single submitter ⚠
p.Met645Val Single submitter ⚠
p.Phe1152Ser Single submitter ⚠
p.Phe1246Leu Single submitter ⚠
p.Phe1341Tyr Single submitter ⚠
p.Phe1773Leu Single submitter ⚠
p.Phe636Ser Single submitter ⚠
p.Phe993Leu Single submitter ⚠
p.Phe9Leu Single submitter ⚠
p.Pro1453Ser Single submitter ⚠
p.Pro1757Arg Single submitter ⚠
p.Pro1757Ser Single submitter ⚠
p.Pro2090Ala Single submitter ⚠
p.Pro2173Leu Single submitter ⚠
p.Pro379Ala Single submitter ⚠
p.Pro379Ser Single submitter ⚠
p.Pro484Ala Single submitter ⚠
p.Pro625Leu Single submitter ⚠
p.Pro720Arg Single submitter ⚠
p.Ser1085Ala Single submitter ⚠
p.Ser1236Tyr Single submitter ⚠
p.Ser1303Asn Single submitter ⚠
p.Ser1304Arg Single submitter ⚠
p.Ser1467Pro Single submitter ⚠
p.Ser1602Ala Single submitter ⚠
p.Ser1626Phe Single submitter ⚠
p.Ser1631Ala Single submitter ⚠
p.Ser1687Gly Single submitter ⚠
p.Ser1749Pro Single submitter ⚠
p.Ser1771Asn Single submitter ⚠
p.Ser1797Tyr Single submitter ⚠
p.Ser1869Leu Single submitter ⚠
p.Ser1986Leu Single submitter ⚠
p.Ser2183Arg Single submitter ⚠
p.Ser328Ala Single submitter ⚠
p.Ser548Arg Single submitter ⚠
p.Ser608Asn Single submitter ⚠
p.Ser709Asn Single submitter ⚠
p.Ser709Ile Single submitter ⚠
p.Ser802Phe Single submitter ⚠
p.Ser81Leu Single submitter ⚠
p.Ser980Leu Single submitter ⚠
p.Thr1307Lys Single submitter ⚠
p.Thr1323Ile Single submitter ⚠
p.Thr1347Met Single submitter ⚠
p.Thr1464Asn Single submitter ⚠
p.Thr1484Met Single submitter ⚠
p.Thr1533Ile Single submitter ⚠
p.Thr1668Ser Single submitter ⚠
p.Thr1766Asn Single submitter ⚠
p.Thr2001Met Single submitter ⚠
p.Thr200Ala Single submitter ⚠
p.Thr2143Ile Single submitter ⚠
p.Thr284Ile Single submitter ⚠
p.Thr318Asn Single submitter ⚠
p.Thr322Met Single submitter ⚠
p.Thr410Met Single submitter ⚠
p.Thr418Met Single submitter ⚠
p.Thr726Ile Single submitter ⚠
p.Thr785Met Single submitter ⚠
p.Tyr1071Cys Single submitter ⚠
p.Tyr1192Phe Single submitter ⚠
p.Tyr1356Asn Single submitter ⚠
p.Tyr1733Cys Single submitter ⚠
p.Tyr430His Single submitter ⚠
p.Val1056Ile Single submitter ⚠
p.Val1229Leu Single submitter ⚠
p.Val1374Ile Single submitter ⚠
p.Val1476Gly Single submitter ⚠
p.Val1810Ala Single submitter ⚠
p.Val1832Ile Single submitter ⚠
p.Val1880Gly Single submitter ⚠
p.Val197Met Single submitter ⚠
p.Val2012Met Single submitter ⚠
p.Val317Ala Single submitter ⚠
p.Val425Met Single submitter ⚠
p.Val654Leu Single submitter ⚠
p.Val698Met Single submitter ⚠
p.Val746Met Single submitter ⚠
p.Val767Ile Single submitter ⚠
p.Val963Ala Single submitter ⚠