DOK1 — 61 ClinVar variants
All ClinVar germline DOK1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
2 Likely benign · 59 Uncertain significance
Full DOK1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 55
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DOK1 p.Ala127Ser Uncertain significance Single submitter
- DOK1 p.Ala137Val Uncertain significance Single submitter
- DOK1 p.Ala254Ser Uncertain significance Single submitter
- DOK1 p.Ala275Ser Uncertain significance Single submitter
- DOK1 p.Ala324Thr Uncertain significance Single submitter
- DOK1 p.Ala369Val Uncertain significance Single submitter
- DOK1 p.Ala410Thr Uncertain significance Single submitter
- DOK1 p.Ala447Thr Uncertain significance Single submitter
- DOK1 p.Ala74Gly Uncertain significance Single submitter
- DOK1 p.Ala86Val Uncertain significance Single submitter
- DOK1 p.Arg207Pro Uncertain significance Single submitter
- DOK1 p.Arg222Cys Uncertain significance Single submitter
- DOK1 p.Arg223Cys Uncertain significance Single submitter
- DOK1 p.Arg251Trp Uncertain significance Single submitter
- DOK1 p.Arg332Trp Uncertain significance Single submitter
- DOK1 p.Arg392Trp Uncertain significance Single submitter
- DOK1 p.Arg415Trp Uncertain significance Single submitter
- DOK1 p.Asn117Lys Uncertain significance Single submitter
- DOK1 p.Asn131Lys Uncertain significance Single submitter
- DOK1 p.Asp290Glu Uncertain significance Single submitter
- DOK1 p.Cys463Arg Uncertain significance Single submitter
- DOK1 p.Gln260Arg Uncertain significance Single submitter
- DOK1 p.Gln347Arg Uncertain significance Single submitter
- DOK1 p.Glu139Asp Uncertain significance Single submitter
- DOK1 p.Glu366Gly Uncertain significance Single submitter
- DOK1 p.Gly238Arg Uncertain significance Single submitter
- DOK1 p.Gly479Ser Uncertain significance Single submitter
- DOK1 p.His250Arg Uncertain significance Single submitter
- DOK1 p.His343Gln Uncertain significance Single submitter
- DOK1 p.Leu340Phe Uncertain significance Single submitter
- DOK1 p.Lys257Arg Uncertain significance Single submitter
- DOK1 p.Lys257Gln Uncertain significance Single submitter
- DOK1 p.Lys278Thr Uncertain significance Single submitter
- DOK1 p.Lys357Arg Uncertain significance Single submitter
- DOK1 p.Lys442Arg Uncertain significance Single submitter
- DOK1 p.Pro128Ser Uncertain significance Single submitter
- DOK1 p.Pro335Arg Uncertain significance Single submitter
- DOK1 p.Pro34His Uncertain significance Single submitter
- DOK1 p.Ser269Thr Uncertain significance Single submitter
- DOK1 p.Ser416Arg Uncertain significance Single submitter
- DOK1 p.Ser443Arg Uncertain significance Single submitter
- DOK1 p.Ser466Phe Uncertain significance Single submitter
- DOK1 p.Ser466Tyr Uncertain significance Single submitter
- DOK1 p.Ser56Ile Uncertain significance Single submitter
- DOK1 p.Thr149Ala Uncertain significance Single submitter
- DOK1 p.Thr204Ile Uncertain significance Single submitter
- DOK1 p.Thr235Met Uncertain significance Single submitter
- DOK1 p.Thr322Met Uncertain significance Single submitter
- DOK1 p.Thr481Ile Uncertain significance Single submitter
- DOK1 p.Trp338Ser Uncertain significance Single submitter
- DOK1 p.Trp388Arg Uncertain significance Single submitter
- DOK1 p.Trp461Gly Uncertain significance Single submitter
- DOK1 p.Val178Ala Uncertain significance Single submitter
- DOK1 p.Val393Met Uncertain significance Single submitter
- DOK1 p.Val5Leu Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All DOK1 variants
Likely benign 2
- p.Asp290Gly Single submitter
- p.Thr435Ala Single submitter
Uncertain significance 59
- p.Ala127Ser Single submitter ⚠
- p.Ala137Val Single submitter ⚠
- p.Ala254Ser Single submitter ⚠
- p.Ala275Ser Single submitter ⚠
- p.Ala324Thr Single submitter ⚠
- p.Ala369Val Single submitter ⚠
- p.Ala410Thr Single submitter ⚠
- p.Ala447Thr Single submitter ⚠
- p.Ala74Gly Single submitter ⚠
- p.Ala86Val Single submitter ⚠
- p.Arg207Pro Single submitter ⚠
- p.Arg222Cys Single submitter ⚠
- p.Arg223Cys Single submitter ⚠
- p.Arg251Trp Single submitter ⚠
- p.Arg332Trp Single submitter ⚠
- p.Arg392Trp Single submitter ⚠
- p.Arg415Trp Single submitter ⚠
- p.Asn117Lys Single submitter ⚠
- p.Asn131Lys Single submitter ⚠
- p.Asp290Glu Single submitter ⚠
- p.Cys463Arg Single submitter ⚠
- p.Gln160His Single submitter ⚠
- p.Gln260Arg Single submitter ⚠
- p.Gln347Arg Single submitter ⚠
- p.Glu139Asp Single submitter ⚠
- p.Glu166Gly Single submitter ⚠
- p.Glu179Lys Single submitter
- p.Glu366Gly Single submitter ⚠
- p.Gly238Arg Single submitter ⚠
- p.Gly479Ser Single submitter ⚠
- p.His250Arg Single submitter ⚠
- p.His343Gln Single submitter ⚠
- p.Leu340Phe Single submitter ⚠
- p.Lys257Arg Single submitter ⚠
- p.Lys257Gln Single submitter ⚠
- p.Lys278Thr Single submitter ⚠
- p.Lys357Arg Single submitter ⚠
- p.Lys442Arg Single submitter ⚠
- p.Pro128Ser Single submitter ⚠
- p.Pro335Arg Single submitter ⚠
- p.Pro34His Single submitter ⚠
- p.Ser269Thr Single submitter ⚠
- p.Ser416Arg Single submitter ⚠
- p.Ser443Arg Single submitter ⚠
- p.Ser466Phe Single submitter ⚠
- p.Ser466Tyr Single submitter ⚠
- p.Ser56Ile Single submitter ⚠
- p.Thr149Ala Single submitter ⚠
- p.Thr204Ile Single submitter ⚠
- p.Thr235Met Single submitter ⚠
- p.Thr322Met Single submitter ⚠
- p.Thr481Ile Single submitter ⚠
- p.Trp156Cys Single submitter
- p.Trp338Ser Single submitter ⚠
- p.Trp388Arg Single submitter ⚠
- p.Trp461Gly Single submitter ⚠
- p.Val178Ala Single submitter ⚠
- p.Val393Met Single submitter ⚠
- p.Val5Leu Single submitter ⚠