DPP10 — 119 ClinVar variants
All ClinVar germline DPP10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 108 flagged for review →
6 Benign · 7 Likely benign · 106 Uncertain significance
Full DPP10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 108
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 59
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DPP10 p.Ala112Ser Uncertain significance Single submitter
- DPP10 p.Ala455Val Uncertain significance Single submitter
- DPP10 p.Ala726Ser Uncertain significance Single submitter
- DPP10 p.Arg212Gln Uncertain significance Single submitter
- DPP10 p.Arg268Gln Uncertain significance Single submitter
- DPP10 p.Arg416Gln Uncertain significance Single submitter
- DPP10 p.Arg497Lys Uncertain significance Single submitter
- DPP10 p.Arg68Ser Uncertain significance Single submitter
- DPP10 p.Arg68Thr Uncertain significance Single submitter
- DPP10 p.Arg87Gln Uncertain significance Single submitter
- DPP10 p.Asn469Ser Uncertain significance Single submitter
- DPP10 p.Asn718Ser Uncertain significance Single submitter
- DPP10 p.Asp432Asn Uncertain significance Single submitter
- DPP10 p.Asp542Asn Uncertain significance Single submitter
- DPP10 p.Asp568Glu Uncertain significance Single submitter
- DPP10 p.Glu249Asp Uncertain significance Single submitter
- DPP10 p.Glu534Gln Uncertain significance Single submitter
- DPP10 p.Glu716Gly Uncertain significance Single submitter
- DPP10 p.Glu716Lys Uncertain significance Single submitter
- DPP10 p.Glu784Lys Uncertain significance Single submitter
- DPP10 p.Glu99Lys Uncertain significance Single submitter
- DPP10 p.Gly394Ala Uncertain significance Single submitter
- DPP10 p.Gly573Ser Uncertain significance Single submitter
- DPP10 p.Gly605Glu Uncertain significance Single submitter
- DPP10 p.His712Gln Uncertain significance Single submitter
- DPP10 p.His82Arg Uncertain significance Single submitter
- DPP10 p.Ile193Val Uncertain significance Single submitter
- DPP10 p.Ile195Met Uncertain significance Single submitter
- DPP10 p.Ile343Val Uncertain significance Single submitter
- DPP10 p.Ile537Thr Uncertain significance Single submitter
- DPP10 p.Ile773Val Uncertain significance Single submitter
- DPP10 p.Leu461Ser Uncertain significance Single submitter
- DPP10 p.Lys126Arg Uncertain significance Single submitter
- DPP10 p.Lys553Arg Uncertain significance Single submitter
- DPP10 p.Met255Thr Uncertain significance Single submitter
- DPP10 p.Met386Leu Uncertain significance Single submitter
- DPP10 p.Met485Ile Uncertain significance Single submitter
- DPP10 p.Phe470Val Uncertain significance Single submitter
- DPP10 p.Phe668Leu Uncertain significance Single submitter
- DPP10 p.Phe79Ser Uncertain significance Single submitter
- DPP10 p.Ser313Asn Uncertain significance Single submitter
- DPP10 p.Ser369Tyr Uncertain significance Single submitter
- DPP10 p.Ser64Leu Uncertain significance Single submitter
- DPP10 p.Ser658Ala Uncertain significance Single submitter
- DPP10 p.Ser700Gly Uncertain significance Single submitter
- DPP10 p.Thr120Ala Uncertain significance Single submitter
- DPP10 p.Thr124Asn Uncertain significance Single submitter
- DPP10 p.Thr414Ile Uncertain significance Single submitter
- DPP10 p.Thr434Ala Uncertain significance Single submitter
- DPP10 p.Thr67Ile Uncertain significance Single submitter
- DPP10 p.Thr728Lys Uncertain significance Single submitter
- DPP10 p.Thr750Ser Uncertain significance Single submitter
- DPP10 p.Tyr295His Uncertain significance Single submitter
- DPP10 p.Tyr320His Uncertain significance Single submitter
- DPP10 p.Tyr477His Uncertain significance Single submitter
- DPP10 p.Val123Ile Uncertain significance Single submitter
- DPP10 p.Val673Leu Uncertain significance Single submitter
- DPP10 p.Val753Ile Uncertain significance Single submitter
- DPP10 p.Val787Leu Uncertain significance Single submitter
Predictors split 49
The independent predictors disagree with each other — read with care.
- DPP10 p.Glu234Asp Benign Multiple submitters
- DPP10 p.Gly601Ser Benign Multiple submitters
- DPP10 p.Ala86Ser Uncertain significance Single submitter
- DPP10 p.Arg268Trp Uncertain significance Single submitter
- DPP10 p.Arg463His Uncertain significance Single submitter
- DPP10 p.Arg87Trp Uncertain significance Single submitter
- DPP10 p.Asn111Thr Uncertain significance Single submitter
- DPP10 p.Asn593Ser Uncertain significance Single submitter
- DPP10 p.Asn710Lys Uncertain significance Single submitter
- DPP10 p.Asn710Thr Uncertain significance Single submitter
- DPP10 p.Asp247Glu Uncertain significance Single submitter
- DPP10 p.Gln29Lys Uncertain significance Single submitter
- DPP10 p.Glu234Gln Uncertain significance Single submitter
- DPP10 p.Glu544Gly Uncertain significance Single submitter
- DPP10 p.His239Gln Uncertain significance Single submitter
- DPP10 p.His242Asn Uncertain significance Single submitter
- DPP10 p.His741Tyr Uncertain significance Single submitter
- DPP10 p.Ile162Met Uncertain significance Single submitter
- DPP10 p.Ile206Thr Uncertain significance Single submitter
- DPP10 p.Ile256Met Uncertain significance Single submitter
- DPP10 p.Ile37Leu Uncertain significance Single submitter
- DPP10 p.Ile37Val Uncertain significance Single submitter
- DPP10 p.Ile656Ser Uncertain significance Single submitter
- DPP10 p.Ile719Met Uncertain significance Single submitter
- DPP10 p.Ile721Val Uncertain significance Single submitter
- DPP10 p.Leu337Phe Uncertain significance Single submitter
- DPP10 p.Leu452Val Uncertain significance Single submitter
- DPP10 p.Leu48Phe Uncertain significance Single submitter
- DPP10 p.Lys331Asn Uncertain significance Single submitter
- DPP10 p.Met323Val Uncertain significance Single submitter
- DPP10 p.Met659Arg Uncertain significance Single submitter
- DPP10 p.Met659Lys Uncertain significance Single submitter
- DPP10 p.Phe489Leu Uncertain significance Single submitter
- DPP10 p.Pro310Ala Uncertain significance Single submitter
- DPP10 p.Ser344Cys Uncertain significance Single submitter
- DPP10 p.Ser446Tyr Uncertain significance Single submitter
- DPP10 p.Ser762Thr Uncertain significance Single submitter
- DPP10 p.Ser98Gly Uncertain significance Single submitter
- DPP10 p.Thr263Ile Uncertain significance Single submitter
- DPP10 p.Thr366Met Uncertain significance Single submitter
- DPP10 p.Thr506Met Uncertain significance Single submitter
- DPP10 p.Thr725Ala Uncertain significance Single submitter
- DPP10 p.Thr772Ala Uncertain significance Single submitter
- DPP10 p.Tyr153His Uncertain significance Single submitter
- DPP10 p.Val179Ile Uncertain significance Single submitter
- DPP10 p.Val415Met Uncertain significance Single submitter
- DPP10 p.Val622Ala Uncertain significance Single submitter
- DPP10 p.Val747Leu Uncertain significance Single submitter
-
DPP10 p.Ile54Met
Uncertain significance
No assertion criteria
DPP10-related disorder
All DPP10 variants
Benign 6
- p.Asp380= Multiple submitters
- p.Glu234Asp Multiple submitters ⚠
- p.Gly601Ser Multiple submitters ⚠
- p.Leu575= Multiple submitters
- c.1531+4A>G Single submitter
- p.Leu609Arg Single submitter
Likely benign 7
- p.His130= Multiple submitters
- p.Ala705Ser Single submitter
- p.Ser64= Single submitter
- c.61-147288C>T No assertion criteria DPP10-related disorder
- c.61-147289G>T No assertion criteria DPP10-related disorder
- p.Gln752Lys No assertion criteria DPP10-related disorder
- p.Lys625Arg No assertion criteria DPP10-related disorder
Uncertain significance 106
- p.Ala112Ser Single submitter ⚠
- p.Ala455Val Single submitter ⚠
- p.Ala726Ser Single submitter ⚠
- p.Ala86Ser Single submitter ⚠
- p.Arg212Gln Single submitter ⚠
- p.Arg268Gln Single submitter ⚠
- p.Arg268Trp Single submitter ⚠
- p.Arg416Gln Single submitter ⚠
- p.Arg463His Single submitter ⚠
- p.Arg497Lys Single submitter ⚠
- p.Arg68Ser Single submitter ⚠
- p.Arg68Thr Single submitter ⚠
- p.Arg87Gln Single submitter ⚠
- p.Arg87Trp Single submitter ⚠
- p.Asn111Thr Single submitter ⚠
- p.Asn469Ser Single submitter ⚠
- p.Asn593Ser Single submitter ⚠
- p.Asn710Lys Single submitter ⚠
- p.Asn710Thr Single submitter ⚠
- p.Asn718Ser Single submitter ⚠
- p.Asp247Glu Single submitter ⚠
- p.Asp432Asn Single submitter ⚠
- p.Asp542Asn Single submitter ⚠
- p.Asp568Glu Single submitter ⚠
- p.Gln29Lys Single submitter ⚠
- p.Glu234Gln Single submitter ⚠
- p.Glu249Asp Single submitter ⚠
- p.Glu534Gln Single submitter ⚠
- p.Glu544Gly Single submitter ⚠
- p.Glu716Gly Single submitter ⚠
- p.Glu716Lys Single submitter ⚠
- p.Glu784Lys Single submitter ⚠
- p.Glu99Lys Single submitter ⚠
- p.Gly394Ala Single submitter ⚠
- p.Gly573Ser Single submitter ⚠
- p.Gly605Glu Single submitter ⚠
- p.His239Gln Single submitter ⚠
- p.His242Asn Single submitter ⚠
- p.His712Gln Single submitter ⚠
- p.His741Tyr Single submitter ⚠
- p.His82Arg Single submitter ⚠
- p.Ile162Met Single submitter ⚠
- p.Ile193Val Single submitter ⚠
- p.Ile195Met Single submitter ⚠
- p.Ile206Thr Single submitter ⚠
- p.Ile256Met Single submitter ⚠
- p.Ile343Val Single submitter ⚠
- p.Ile37Leu Single submitter ⚠
- p.Ile37Val Single submitter ⚠
- p.Ile537Thr Single submitter ⚠
- p.Ile656Ser Single submitter ⚠
- p.Ile719Met Single submitter ⚠
- p.Ile721Val Single submitter ⚠
- p.Ile773Val Single submitter ⚠
- p.Leu337Phe Single submitter ⚠
- p.Leu452Val Single submitter ⚠
- p.Leu461Ser Single submitter ⚠
- p.Leu48Phe Single submitter ⚠
- p.Lys126Arg Single submitter ⚠
- p.Lys331Asn Single submitter ⚠
- p.Lys553Arg Single submitter ⚠
- p.Met255Thr Single submitter ⚠
- p.Met323Val Single submitter ⚠
- p.Met386Leu Single submitter ⚠
- p.Met485Ile Single submitter ⚠
- p.Met659Arg Single submitter ⚠
- p.Met659Lys Single submitter ⚠
- p.Phe470Val Single submitter ⚠
- p.Phe489Leu Single submitter ⚠
- p.Phe668Leu Single submitter ⚠
- p.Phe79Ser Single submitter ⚠
- p.Pro310Ala Single submitter ⚠
- p.Ser313Asn Single submitter ⚠
- p.Ser344Cys Single submitter ⚠
- p.Ser369Tyr Single submitter ⚠
- p.Ser446Tyr Single submitter ⚠
- p.Ser64Leu Single submitter ⚠
- p.Ser658Ala Single submitter ⚠
- p.Ser700Gly Single submitter ⚠
- p.Ser762Thr Single submitter ⚠
- p.Ser98Gly Single submitter ⚠
- p.Thr120Ala Single submitter ⚠
- p.Thr124Asn Single submitter ⚠
- p.Thr263Ile Single submitter ⚠
- p.Thr366Met Single submitter ⚠
- p.Thr414Ile Single submitter ⚠
- p.Thr434Ala Single submitter ⚠
- p.Thr506Met Single submitter ⚠
- p.Thr67Ile Single submitter ⚠
- p.Thr725Ala Single submitter ⚠
- p.Thr728Lys Single submitter ⚠
- p.Thr750Ser Single submitter ⚠
- p.Thr772Ala Single submitter ⚠
- p.Tyr153His Single submitter ⚠
- p.Tyr295His Single submitter ⚠
- p.Tyr320His Single submitter ⚠
- p.Tyr477His Single submitter ⚠
- p.Val123Ile Single submitter ⚠
- p.Val179Ile Single submitter ⚠
- p.Val415Met Single submitter ⚠
- p.Val622Ala Single submitter ⚠
- p.Val673Leu Single submitter ⚠
- p.Val747Leu Single submitter ⚠
- p.Val753Ile Single submitter ⚠
- p.Val787Leu Single submitter ⚠
- p.Ile54Met No assertion criteria DPP10-related disorder ⚠