DPPA4 — 24 ClinVar variants
All ClinVar germline DPPA4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
1 Likely benign · 23 Uncertain significance
Full DPPA4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DPPA4 p.Ala139Thr Uncertain significance Single submitter
- DPPA4 p.Asn181His Uncertain significance Single submitter
- DPPA4 p.Asn34Asp Uncertain significance Single submitter
- DPPA4 p.Gln146Arg Uncertain significance Single submitter
- DPPA4 p.Gln223Lys Uncertain significance Single submitter
- DPPA4 p.Glu262Lys Uncertain significance Single submitter
- DPPA4 p.Gly174Arg Uncertain significance Single submitter
- DPPA4 p.Lys17Arg Uncertain significance Single submitter
- DPPA4 p.Lys260Arg Uncertain significance Single submitter
- DPPA4 p.Lys59Glu Uncertain significance Single submitter
- DPPA4 p.Pro166Leu Uncertain significance Single submitter
- DPPA4 p.Pro36Ala Uncertain significance Single submitter
- DPPA4 p.Thr183Ser Uncertain significance Single submitter
- DPPA4 p.Thr9Lys Uncertain significance Single submitter
- DPPA4 p.Tyr118Cys Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- DPPA4 p.Ala201Pro Uncertain significance Single submitter
- DPPA4 p.His95Asn Uncertain significance Single submitter
- DPPA4 p.Leu2Trp Uncertain significance Single submitter
- DPPA4 p.Leu88Val Uncertain significance Single submitter
- DPPA4 p.Ser197Tyr Uncertain significance Single submitter
- DPPA4 p.Thr156Met Uncertain significance Single submitter
- DPPA4 p.Val228Asp Uncertain significance Single submitter
-
DPPA4 p.Trp303Arg
Uncertain significance
No assertion criteria
prostate cancer
All DPPA4 variants
Likely benign 1
- p.Gly188Glu Single submitter
Uncertain significance 23
- p.Ala139Thr Single submitter ⚠
- p.Ala201Pro Single submitter ⚠
- p.Asn181His Single submitter ⚠
- p.Asn34Asp Single submitter ⚠
- p.Gln146Arg Single submitter ⚠
- p.Gln223Lys Single submitter ⚠
- p.Glu262Lys Single submitter ⚠
- p.Gly174Arg Single submitter ⚠
- p.His95Asn Single submitter ⚠
- p.Leu2Trp Single submitter ⚠
- p.Leu88Val Single submitter ⚠
- p.Lys17Arg Single submitter ⚠
- p.Lys260Arg Single submitter ⚠
- p.Lys59Glu Single submitter ⚠
- p.Pro166Leu Single submitter ⚠
- p.Pro36Ala Single submitter ⚠
- p.Ser197Tyr Single submitter ⚠
- p.Thr156Met Single submitter ⚠
- p.Thr183Ser Single submitter ⚠
- p.Thr9Lys Single submitter ⚠
- p.Tyr118Cys Single submitter ⚠
- p.Val228Asp Single submitter ⚠
- p.Trp303Arg No assertion criteria prostate cancer ⚠