DRAM1 — 23 ClinVar variants
All ClinVar germline DRAM1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
1 Likely benign · 22 Uncertain significance
Full DRAM1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DRAM1 p.Ala169Thr Uncertain significance Single submitter
- DRAM1 p.Asn235Ile Uncertain significance Single submitter
- DRAM1 p.Asn235Ser Uncertain significance Single submitter
- DRAM1 p.Gly106Arg Uncertain significance Single submitter
- DRAM1 p.Gly54Asp Uncertain significance Single submitter
- DRAM1 p.Ile55Ser Uncertain significance Single submitter
- DRAM1 p.Leu40Phe Uncertain significance Single submitter
- DRAM1 p.Leu40Pro Uncertain significance Single submitter
- DRAM1 p.Ser155Leu Uncertain significance Single submitter
- DRAM1 p.Thr137Ala Uncertain significance Single submitter
- DRAM1 p.Thr46Met Uncertain significance Single submitter
- DRAM1 p.Thr84Asn Uncertain significance Single submitter
- DRAM1 p.Val199Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- DRAM1 p.Asn37Ile Uncertain significance Single submitter
- DRAM1 p.Glu187Ala Uncertain significance Single submitter
- DRAM1 p.Ile159Met Uncertain significance Single submitter
- DRAM1 p.Leu116Phe Uncertain significance Single submitter
- DRAM1 p.Leu186Met Uncertain significance Single submitter
- DRAM1 p.Ser231Tyr Uncertain significance Single submitter
- DRAM1 p.Ser63Ala Uncertain significance Single submitter
- DRAM1 p.Trp151Gly Uncertain significance Single submitter
- DRAM1 p.Tyr75Phe Uncertain significance Single submitter
- DRAM1 p.Val176Ala Likely benign Single submitter
All DRAM1 variants
Likely benign 1
- p.Val176Ala Single submitter ⚠
Uncertain significance 22
- p.Ala169Thr Single submitter ⚠
- p.Asn235Ile Single submitter ⚠
- p.Asn235Ser Single submitter ⚠
- p.Asn37Ile Single submitter ⚠
- p.Glu187Ala Single submitter ⚠
- p.Gly106Arg Single submitter ⚠
- p.Gly54Asp Single submitter ⚠
- p.Ile159Met Single submitter ⚠
- p.Ile55Ser Single submitter ⚠
- p.Leu116Phe Single submitter ⚠
- p.Leu186Met Single submitter ⚠
- p.Leu40Phe Single submitter ⚠
- p.Leu40Pro Single submitter ⚠
- p.Ser155Leu Single submitter ⚠
- p.Ser231Tyr Single submitter ⚠
- p.Ser63Ala Single submitter ⚠
- p.Thr137Ala Single submitter ⚠
- p.Thr46Met Single submitter ⚠
- p.Thr84Asn Single submitter ⚠
- p.Trp151Gly Single submitter ⚠
- p.Tyr75Phe Single submitter ⚠
- p.Val199Ile Single submitter ⚠