DRC10 — 21 ClinVar variants
All ClinVar germline DRC10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 19 flagged for review →
2 Likely benign · 19 Uncertain significance
Full DRC10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 19
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DRC10 p.Ala31Thr Uncertain significance Single submitter
- DRC10 p.Ala403Val Uncertain significance Single submitter
- DRC10 p.Ala59Val Uncertain significance Single submitter
- DRC10 p.Arg426Gln Uncertain significance Single submitter
- DRC10 p.Gln181Arg Uncertain significance Single submitter
- DRC10 p.Gly374Arg Uncertain significance Single submitter
- DRC10 p.Ile184Val Uncertain significance Single submitter
- DRC10 p.Tyr12Cys Uncertain significance Single submitter
- DRC10 p.Val105Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- DRC10 p.Ala393Ser Uncertain significance Single submitter
- DRC10 p.Ala404Thr Uncertain significance Single submitter
- DRC10 p.Arg191Cys Uncertain significance Single submitter
- DRC10 p.Arg399Gly Uncertain significance Single submitter
- DRC10 p.Gln172Pro Uncertain significance Single submitter
- DRC10 p.Glu204Lys Uncertain significance Single submitter
- DRC10 p.Glu364Lys Uncertain significance Single submitter
- DRC10 p.Lys388Glu Uncertain significance Single submitter
- DRC10 p.Ser387Pro Uncertain significance Single submitter
- DRC10 p.Thr405Met Uncertain significance Single submitter
All DRC10 variants
Likely benign 2
- p.Gln218Arg Single submitter
- p.Val87Ile Single submitter
Uncertain significance 19
- p.Ala31Thr Single submitter ⚠
- p.Ala393Ser Single submitter ⚠
- p.Ala403Val Single submitter ⚠
- p.Ala404Thr Single submitter ⚠
- p.Ala59Val Single submitter ⚠
- p.Arg191Cys Single submitter ⚠
- p.Arg399Gly Single submitter ⚠
- p.Arg426Gln Single submitter ⚠
- p.Gln172Pro Single submitter ⚠
- p.Gln181Arg Single submitter ⚠
- p.Glu204Lys Single submitter ⚠
- p.Glu364Lys Single submitter ⚠
- p.Gly374Arg Single submitter ⚠
- p.Ile184Val Single submitter ⚠
- p.Lys388Glu Single submitter ⚠
- p.Ser387Pro Single submitter ⚠
- p.Thr405Met Single submitter ⚠
- p.Tyr12Cys Single submitter ⚠
- p.Val105Ile Single submitter ⚠