DRC11 — 49 ClinVar variants
All ClinVar germline DRC11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
3 Likely benign · 46 Uncertain significance
Full DRC11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DRC11 p.Ala574Pro Uncertain significance Single submitter
- DRC11 p.Ala594Val Uncertain significance Single submitter
- DRC11 p.Ala735Val Uncertain significance Single submitter
- DRC11 p.Ala806Val Uncertain significance Single submitter
- DRC11 p.Arg760Gln Uncertain significance Single submitter
- DRC11 p.Asn400Thr Uncertain significance Single submitter
- DRC11 p.Glu172Lys Uncertain significance Single submitter
- DRC11 p.Glu232Lys Uncertain significance Single submitter
- DRC11 p.Glu787Lys Uncertain significance Single submitter
- DRC11 p.Gly313Arg Uncertain significance Single submitter
- DRC11 p.Gly324Arg Uncertain significance Single submitter
- DRC11 p.Gly819Arg Uncertain significance Single submitter
- DRC11 p.His661Asn Uncertain significance Single submitter
- DRC11 p.Ile329Val Uncertain significance Single submitter
- DRC11 p.Ile588Asn Uncertain significance Single submitter
- DRC11 p.Leu542Pro Uncertain significance Single submitter
- DRC11 p.Leu729Phe Uncertain significance Single submitter
- DRC11 p.Lys23Thr Uncertain significance Single submitter
- DRC11 p.Pro25Ala Uncertain significance Single submitter
- DRC11 p.Ser732Asn Uncertain significance Single submitter
- DRC11 p.Thr207Asn Uncertain significance Single submitter
- DRC11 p.Thr207Ile Uncertain significance Single submitter
- DRC11 p.Tyr707Cys Uncertain significance Single submitter
- DRC11 p.Val291Met Uncertain significance Single submitter
- DRC11 p.Val561Gly Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- DRC11 p.Ala143Val Uncertain significance Single submitter
- DRC11 p.Ala327Pro Likely benign Single submitter
- DRC11 p.Ala804Gly Uncertain significance Single submitter
- DRC11 p.Arg224His Uncertain significance Single submitter
- DRC11 p.Arg531Cys Uncertain significance Single submitter
- DRC11 p.Arg626Gln Uncertain significance Single submitter
- DRC11 p.Arg683His Uncertain significance Single submitter
- DRC11 p.Arg69Gln Uncertain significance Single submitter
- DRC11 p.Arg761Trp Uncertain significance Single submitter
- DRC11 p.Asp299Val Uncertain significance Single submitter
- DRC11 p.Gln439Pro Uncertain significance Single submitter
- DRC11 p.Glu442Lys Uncertain significance Single submitter
- DRC11 p.Glu505Gly Uncertain significance Single submitter
- DRC11 p.Glu785Asp Uncertain significance Single submitter
- DRC11 p.Ile141Arg Uncertain significance Single submitter
- DRC11 p.Leu423Val Uncertain significance Single submitter
- DRC11 p.Leu502Val Uncertain significance Single submitter
- DRC11 p.Lys294Glu Uncertain significance Single submitter
- DRC11 p.Met538Thr Uncertain significance Single submitter
- DRC11 p.Thr312Ile Uncertain significance Single submitter
- DRC11 p.Thr96Lys Uncertain significance Single submitter
- DRC11 p.Thr96Met Uncertain significance Single submitter
All DRC11 variants
Likely benign 3
- p.Ala327Pro Single submitter ⚠
- p.Val321Ile Single submitter
- p.Val47Ile Single submitter
Uncertain significance 46
- p.Ala143Val Single submitter ⚠
- p.Ala574Pro Single submitter ⚠
- p.Ala594Val Single submitter ⚠
- p.Ala735Val Single submitter ⚠
- p.Ala804Gly Single submitter ⚠
- p.Ala806Val Single submitter ⚠
- p.Arg224His Single submitter ⚠
- p.Arg531Cys Single submitter ⚠
- p.Arg626Gln Single submitter ⚠
- p.Arg683His Single submitter ⚠
- p.Arg69Gln Single submitter ⚠
- p.Arg760Gln Single submitter ⚠
- p.Arg761Trp Single submitter ⚠
- p.Asn400Thr Single submitter ⚠
- p.Asp299Val Single submitter ⚠
- p.Gln439Pro Single submitter ⚠
- p.Glu172Lys Single submitter ⚠
- p.Glu232Lys Single submitter ⚠
- p.Glu442Lys Single submitter ⚠
- p.Glu505Gly Single submitter ⚠
- p.Glu785Asp Single submitter ⚠
- p.Glu787Lys Single submitter ⚠
- p.Gly313Arg Single submitter ⚠
- p.Gly324Arg Single submitter ⚠
- p.Gly819Arg Single submitter ⚠
- p.His661Asn Single submitter ⚠
- p.Ile141Arg Single submitter ⚠
- p.Ile329Val Single submitter ⚠
- p.Ile588Asn Single submitter ⚠
- p.Leu423Val Single submitter ⚠
- p.Leu502Val Single submitter ⚠
- p.Leu542Pro Single submitter ⚠
- p.Leu729Phe Single submitter ⚠
- p.Lys23Thr Single submitter ⚠
- p.Lys294Glu Single submitter ⚠
- p.Met538Thr Single submitter ⚠
- p.Pro25Ala Single submitter ⚠
- p.Ser732Asn Single submitter ⚠
- p.Thr207Asn Single submitter ⚠
- p.Thr207Ile Single submitter ⚠
- p.Thr312Ile Single submitter ⚠
- p.Thr96Lys Single submitter ⚠
- p.Thr96Met Single submitter ⚠
- p.Tyr707Cys Single submitter ⚠
- p.Val291Met Single submitter ⚠
- p.Val561Gly Single submitter ⚠