DRC9 — 23 ClinVar variants
All ClinVar germline DRC9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
2 Benign · 5 Likely benign · 16 Uncertain significance
Full DRC9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DRC9 p.Ala260Val Uncertain significance Single submitter
- DRC9 p.Asn100Ser Uncertain significance Single submitter
- DRC9 p.Asn105Lys Uncertain significance Single submitter
- DRC9 p.Asp148Gly Uncertain significance Single submitter
- DRC9 p.Asp361Asn Uncertain significance Single submitter
- DRC9 p.Asp4Asn Uncertain significance Single submitter
- DRC9 p.Glu142Lys Uncertain significance Single submitter
- DRC9 p.Glu257Lys Uncertain significance Single submitter
- DRC9 p.Ile123Val Uncertain significance Single submitter
- DRC9 p.Pro131Ala Uncertain significance Single submitter
- DRC9 p.Ser200Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- DRC9 p.Glu163Gly Uncertain significance Single submitter
- DRC9 p.Glu185Asp Uncertain significance Single submitter
- DRC9 p.Glu313Ala Benign Single submitter
- DRC9 p.Leu195Val Uncertain significance Single submitter
- DRC9 p.Pro50Leu Likely benign Single submitter
- DRC9 p.Thr164Arg Uncertain significance Single submitter
- DRC9 p.Val178Met Uncertain significance Single submitter
All DRC9 variants
Benign 2
- p.Leu75= Multiple submitters
- p.Glu313Ala Single submitter ⚠
Likely benign 5
- p.Arg411Lys Multiple submitters
- p.Glu27Lys Single submitter
- p.Met111Val Single submitter
- p.Pro50Leu Single submitter ⚠
- p.Val94Met Single submitter
Uncertain significance 16
- p.Ala260Val Single submitter ⚠
- p.Asn100Ser Single submitter ⚠
- p.Asn105Lys Single submitter ⚠
- p.Asp148Gly Single submitter ⚠
- p.Asp361Asn Single submitter ⚠
- p.Asp4Asn Single submitter ⚠
- p.Glu142Lys Single submitter ⚠
- p.Glu163Gly Single submitter ⚠
- p.Glu185Asp Single submitter ⚠
- p.Glu257Lys Single submitter ⚠
- p.Ile123Val Single submitter ⚠
- p.Leu195Val Single submitter ⚠
- p.Pro131Ala Single submitter ⚠
- p.Ser200Ile Single submitter ⚠
- p.Thr164Arg Single submitter ⚠
- p.Val178Met Single submitter ⚠