DSTN — 12 ClinVar variants
All ClinVar germline DSTN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 12 flagged for review →
12 Uncertain significance
Full DSTN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 12
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DSTN p.Asp122Gly Uncertain significance Single submitter
- DSTN p.Gly4Val Uncertain significance Single submitter
- DSTN p.Ile131Val Uncertain significance Single submitter
- DSTN p.Leu108Val Uncertain significance Single submitter
- DSTN p.Lys126Glu Uncertain significance Single submitter
- DSTN p.Met100Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- DSTN p.Ala87Thr Uncertain significance Single submitter
- DSTN p.Arg81Cys Uncertain significance Single submitter
- DSTN p.Glu51Asp Uncertain significance Single submitter
- DSTN p.Glu51Gly Uncertain significance Single submitter
- DSTN p.Ile148Thr Uncertain significance Single submitter
- DSTN p.Pro164Arg Uncertain significance Single submitter
All DSTN variants
Uncertain significance 12
- p.Ala87Thr Single submitter ⚠
- p.Arg81Cys Single submitter ⚠
- p.Asp122Gly Single submitter ⚠
- p.Glu51Asp Single submitter ⚠
- p.Glu51Gly Single submitter ⚠
- p.Gly4Val Single submitter ⚠
- p.Ile131Val Single submitter ⚠
- p.Ile148Thr Single submitter ⚠
- p.Leu108Val Single submitter ⚠
- p.Lys126Glu Single submitter ⚠
- p.Met100Ile Single submitter ⚠
- p.Pro164Arg Single submitter ⚠