DTX3 — 35 ClinVar variants
All ClinVar germline DTX3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
1 Likely benign · 34 Uncertain significance
Full DTX3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DTX3 p.Ala120Thr Uncertain significance Single submitter
- DTX3 p.Ala198Ser Uncertain significance Single submitter
- DTX3 p.Ala70Thr Uncertain significance Single submitter
- DTX3 p.Arg119His Uncertain significance Single submitter
- DTX3 p.Arg136Pro Uncertain significance Single submitter
- DTX3 p.Arg136Trp Uncertain significance Single submitter
- DTX3 p.Arg152Cys Uncertain significance Single submitter
- DTX3 p.Arg154Leu Uncertain significance Single submitter
- DTX3 p.Arg41Gln Uncertain significance Single submitter
- DTX3 p.Asn216Ser Uncertain significance Single submitter
- DTX3 p.Gln99His Uncertain significance Single submitter
- DTX3 p.Gly109Arg Uncertain significance Single submitter
- DTX3 p.Gly112Glu Uncertain significance Single submitter
- DTX3 p.Leu102Val Uncertain significance Single submitter
- DTX3 p.Lys223Arg Uncertain significance Single submitter
- DTX3 p.Lys23Arg Uncertain significance Single submitter
- DTX3 p.Lys80Arg Uncertain significance Single submitter
- DTX3 p.Pro147Leu Uncertain significance Single submitter
- DTX3 p.Pro151Ser Uncertain significance Single submitter
- DTX3 p.Pro329Ser Uncertain significance Single submitter
- DTX3 p.Pro68Ser Uncertain significance Single submitter
- DTX3 p.Pro69Arg Uncertain significance Single submitter
- DTX3 p.Pro69Leu Uncertain significance Single submitter
- DTX3 p.Thr280Asn Uncertain significance Single submitter
- DTX3 p.Thr33Asn Uncertain significance Single submitter
- DTX3 p.Val243Ile Uncertain significance Single submitter
- DTX3 p.Val4Ile Uncertain significance Single submitter
- DTX3 p.Val4Leu Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- DTX3 p.Arg41Trp Uncertain significance Single submitter
- DTX3 p.Pro139Ser Uncertain significance Single submitter
- DTX3 p.Pro140Ala Uncertain significance Single submitter
- DTX3 p.Pro140Arg Uncertain significance Single submitter
- DTX3 p.Pro142Ser Uncertain significance Single submitter
- DTX3 p.Val195Met Uncertain significance Single submitter
All DTX3 variants
Likely benign 1
- p.Leu323= Single submitter
Uncertain significance 34
- p.Ala120Thr Single submitter ⚠
- p.Ala198Ser Single submitter ⚠
- p.Ala70Thr Single submitter ⚠
- p.Arg119His Single submitter ⚠
- p.Arg136Pro Single submitter ⚠
- p.Arg136Trp Single submitter ⚠
- p.Arg152Cys Single submitter ⚠
- p.Arg154Leu Single submitter ⚠
- p.Arg41Gln Single submitter ⚠
- p.Arg41Trp Single submitter ⚠
- p.Asn216Ser Single submitter ⚠
- p.Gln99His Single submitter ⚠
- p.Gly109Arg Single submitter ⚠
- p.Gly112Glu Single submitter ⚠
- p.Leu102Val Single submitter ⚠
- p.Lys223Arg Single submitter ⚠
- p.Lys23Arg Single submitter ⚠
- p.Lys80Arg Single submitter ⚠
- p.Pro139Ser Single submitter ⚠
- p.Pro140Ala Single submitter ⚠
- p.Pro140Arg Single submitter ⚠
- p.Pro142Ser Single submitter ⚠
- p.Pro147Leu Single submitter ⚠
- p.Pro151Ser Single submitter ⚠
- p.Pro329Ser Single submitter ⚠
- p.Pro68Ser Single submitter ⚠
- p.Pro69Arg Single submitter ⚠
- p.Pro69Leu Single submitter ⚠
- p.Thr280Asn Single submitter ⚠
- p.Thr33Asn Single submitter ⚠
- p.Val195Met Single submitter ⚠
- p.Val243Ile Single submitter ⚠
- p.Val4Ile Single submitter ⚠
- p.Val4Leu Single submitter ⚠