DUS2 — 70 ClinVar variants
All ClinVar germline DUS2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
1 Likely benign · 69 Uncertain significance
Full DUS2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DUS2 p.Ala181Thr Uncertain significance Single submitter
- DUS2 p.Ala244Gly Uncertain significance Single submitter
- DUS2 p.Ala346Val Uncertain significance Single submitter
- DUS2 p.Ala36Val Uncertain significance Single submitter
- DUS2 p.Ala425Val Uncertain significance Single submitter
- DUS2 p.Arg157Cys Uncertain significance Single submitter
- DUS2 p.Arg190Gln Uncertain significance Single submitter
- DUS2 p.Arg243Gln Uncertain significance Single submitter
- DUS2 p.Arg379Gln Uncertain significance Single submitter
- DUS2 p.Arg397His Uncertain significance Single submitter
- DUS2 p.Arg464Thr Uncertain significance Single submitter
- DUS2 p.Asp46Asn Uncertain significance Single submitter
- DUS2 p.Asp64Asn Uncertain significance Single submitter
- DUS2 p.Asp70Asn Uncertain significance Single submitter
- DUS2 p.Cys154Arg Uncertain significance Single submitter
- DUS2 p.Cys430Tyr Uncertain significance Single submitter
- DUS2 p.Gln223His Uncertain significance Single submitter
- DUS2 p.Gln265Arg Uncertain significance Single submitter
- DUS2 p.Gln305Arg Uncertain significance Single submitter
- DUS2 p.Gln341His Uncertain significance Single submitter
- DUS2 p.Gln87His Uncertain significance Single submitter
- DUS2 p.Glu42Ala Uncertain significance Single submitter
- DUS2 p.His220Arg Uncertain significance Single submitter
- DUS2 p.Ile251Val Uncertain significance Single submitter
- DUS2 p.Ile310Val Uncertain significance Single submitter
- DUS2 p.Leu32Pro Uncertain significance Single submitter
- DUS2 p.Leu414Ser Uncertain significance Single submitter
- DUS2 p.Leu448Ser Uncertain significance Single submitter
- DUS2 p.Lys48Arg Uncertain significance Single submitter
- DUS2 p.Met19Thr Uncertain significance Single submitter
- DUS2 p.Phe479Ile Uncertain significance Single submitter
- DUS2 p.Pro249Ala Uncertain significance Single submitter
- DUS2 p.Pro386Ser Uncertain significance Single submitter
- DUS2 p.Val391Phe Uncertain significance Single submitter
Predictors split 35
The independent predictors disagree with each other — read with care.
- DUS2 p.Ala271Val Uncertain significance Single submitter
- DUS2 p.Ala336Thr Uncertain significance Single submitter
- DUS2 p.Arg101Thr Uncertain significance Single submitter
- DUS2 p.Arg149Pro Uncertain significance Single submitter
- DUS2 p.Arg171Trp Uncertain significance Single submitter
- DUS2 p.Arg187Trp Uncertain significance Single submitter
- DUS2 p.Arg361Trp Uncertain significance Single submitter
- DUS2 p.Arg393His Uncertain significance Single submitter
- DUS2 p.Arg432Gln Uncertain significance Single submitter
- DUS2 p.Arg451Gln Uncertain significance Single submitter
- DUS2 p.Arg453Trp Uncertain significance Single submitter
- DUS2 p.Arg54Lys Uncertain significance Single submitter
- DUS2 p.Asn12Thr Uncertain significance Single submitter
- DUS2 p.Asn276Ser Uncertain significance Single submitter
- DUS2 p.Asp416Ala Uncertain significance Single submitter
- DUS2 p.Gln222Pro Uncertain significance Single submitter
- DUS2 p.Gln408Pro Uncertain significance Single submitter
- DUS2 p.Gly256Ser Uncertain significance Single submitter
- DUS2 p.Gly317Asp Uncertain significance Single submitter
- DUS2 p.Ile137Thr Uncertain significance Single submitter
- DUS2 p.Ile402Asn Uncertain significance Single submitter
- DUS2 p.Leu482Trp Uncertain significance Single submitter
- DUS2 p.Lys13Arg Uncertain significance Single submitter
- DUS2 p.Lys450Arg Uncertain significance Single submitter
- DUS2 p.Lys476Arg Uncertain significance Single submitter
- DUS2 p.Met246Val Uncertain significance Single submitter
- DUS2 p.Met27Val Uncertain significance Single submitter
- DUS2 p.Ser161Leu Uncertain significance Single submitter
- DUS2 p.Ser295Leu Uncertain significance Single submitter
- DUS2 p.Thr143Ile Uncertain significance Single submitter
- DUS2 p.Thr390Met Uncertain significance Single submitter
- DUS2 p.Val20Ile Uncertain significance Single submitter
- DUS2 p.Val22Ile Uncertain significance Single submitter
- DUS2 p.Val272Met Uncertain significance Single submitter
- DUS2 p.Val429Ile Uncertain significance Single submitter
All DUS2 variants
Likely benign 1
- p.Asn214= Single submitter
Uncertain significance 69
- p.Ala181Thr Single submitter ⚠
- p.Ala244Gly Single submitter ⚠
- p.Ala271Val Single submitter ⚠
- p.Ala336Thr Single submitter ⚠
- p.Ala346Val Single submitter ⚠
- p.Ala36Val Single submitter ⚠
- p.Ala425Val Single submitter ⚠
- p.Arg101Thr Single submitter ⚠
- p.Arg149Pro Single submitter ⚠
- p.Arg157Cys Single submitter ⚠
- p.Arg171Trp Single submitter ⚠
- p.Arg187Trp Single submitter ⚠
- p.Arg190Gln Single submitter ⚠
- p.Arg243Gln Single submitter ⚠
- p.Arg361Trp Single submitter ⚠
- p.Arg379Gln Single submitter ⚠
- p.Arg393His Single submitter ⚠
- p.Arg397His Single submitter ⚠
- p.Arg432Gln Single submitter ⚠
- p.Arg451Gln Single submitter ⚠
- p.Arg453Trp Single submitter ⚠
- p.Arg464Thr Single submitter ⚠
- p.Arg54Lys Single submitter ⚠
- p.Asn12Thr Single submitter ⚠
- p.Asn276Ser Single submitter ⚠
- p.Asp416Ala Single submitter ⚠
- p.Asp46Asn Single submitter ⚠
- p.Asp64Asn Single submitter ⚠
- p.Asp70Asn Single submitter ⚠
- p.Cys154Arg Single submitter ⚠
- p.Cys430Tyr Single submitter ⚠
- p.Gln222Pro Single submitter ⚠
- p.Gln223His Single submitter ⚠
- p.Gln265Arg Single submitter ⚠
- p.Gln305Arg Single submitter ⚠
- p.Gln341His Single submitter ⚠
- p.Gln408Pro Single submitter ⚠
- p.Gln87His Single submitter ⚠
- p.Glu42Ala Single submitter ⚠
- p.Gly256Ser Single submitter ⚠
- p.Gly317Asp Single submitter ⚠
- p.His220Arg Single submitter ⚠
- p.Ile137Thr Single submitter ⚠
- p.Ile251Val Single submitter ⚠
- p.Ile310Val Single submitter ⚠
- p.Ile402Asn Single submitter ⚠
- p.Leu32Pro Single submitter ⚠
- p.Leu414Ser Single submitter ⚠
- p.Leu448Ser Single submitter ⚠
- p.Leu482Trp Single submitter ⚠
- p.Lys13Arg Single submitter ⚠
- p.Lys450Arg Single submitter ⚠
- p.Lys476Arg Single submitter ⚠
- p.Lys48Arg Single submitter ⚠
- p.Met19Thr Single submitter ⚠
- p.Met246Val Single submitter ⚠
- p.Met27Val Single submitter ⚠
- p.Phe479Ile Single submitter ⚠
- p.Pro249Ala Single submitter ⚠
- p.Pro386Ser Single submitter ⚠
- p.Ser161Leu Single submitter ⚠
- p.Ser295Leu Single submitter ⚠
- p.Thr143Ile Single submitter ⚠
- p.Thr390Met Single submitter ⚠
- p.Val20Ile Single submitter ⚠
- p.Val22Ile Single submitter ⚠
- p.Val272Met Single submitter ⚠
- p.Val391Phe Single submitter ⚠
- p.Val429Ile Single submitter ⚠