DUSP11 — 53 ClinVar variants
All ClinVar germline DUSP11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
3 Benign · 6 Likely benign · 44 Uncertain significance
Full DUSP11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DUSP11 c.-104G>T Uncertain significance Single submitter
- DUSP11 c.-108G>T Uncertain significance Single submitter
- DUSP11 c.-116G>A Uncertain significance Single submitter
- DUSP11 c.-117C>G Uncertain significance Single submitter
- DUSP11 c.-117C>T Uncertain significance Single submitter
- DUSP11 c.-118G>T Uncertain significance Single submitter
- DUSP11 c.-12C>T Uncertain significance Single submitter
- DUSP11 c.-17G>C Uncertain significance Single submitter
- DUSP11 c.-29C>T Uncertain significance Single submitter
- DUSP11 c.-2A>T Uncertain significance Single submitter
- DUSP11 c.-30G>A Uncertain significance Single submitter
- DUSP11 c.-36G>A Uncertain significance Single submitter
- DUSP11 c.-56C>T Uncertain significance Single submitter
- DUSP11 c.-72C>T Uncertain significance Single submitter
- DUSP11 c.-77C>T Uncertain significance Single submitter
- DUSP11 c.-83T>C Uncertain significance Single submitter
- DUSP11 c.-84T>G Uncertain significance Single submitter
- DUSP11 c.-86G>A Uncertain significance Single submitter
- DUSP11 c.-98G>C Uncertain significance Single submitter
- DUSP11 p.Ala306Thr Uncertain significance Single submitter
- DUSP11 p.Arg304Pro Uncertain significance Single submitter
- DUSP11 p.Arg309Gly Uncertain significance Single submitter
- DUSP11 p.Cys152Arg Uncertain significance Single submitter
- DUSP11 p.Gln200Arg Uncertain significance Single submitter
- DUSP11 p.Gln245His Uncertain significance Single submitter
- DUSP11 p.Gly27Arg Uncertain significance Single submitter
- DUSP11 p.Gly28Arg Uncertain significance Single submitter
- DUSP11 p.His223Arg Uncertain significance Single submitter
- DUSP11 p.His278Arg Uncertain significance Single submitter
- DUSP11 p.Ile196Val Uncertain significance Single submitter
- DUSP11 p.Leu279Phe Uncertain significance Single submitter
- DUSP11 p.Lys234Ile Uncertain significance Single submitter
- DUSP11 p.Met45Val Uncertain significance Single submitter
- DUSP11 p.Pro250Leu Uncertain significance Single submitter
- DUSP11 p.Pro314Arg Uncertain significance Single submitter
- DUSP11 p.Ser303Ile Uncertain significance Single submitter
- DUSP11 p.Tyr239Cys Uncertain significance Single submitter
All DUSP11 variants
Benign 3
- c.178-7G>C Multiple submitters
- c.794+5C>G Multiple submitters
- c.-118G>A Multiple submitters
Likely benign 6
- c.-92T>C Single submitter
- c.-95T>G Single submitter
- p.Ala222Thr Single submitter
- p.Pro213Ser Single submitter
- p.Tyr289Cys Single submitter
- p.Val173Met Single submitter
Uncertain significance 44
- c.-104G>T Single submitter ⚠
- c.-108G>T Single submitter ⚠
- c.-116G>A Single submitter ⚠
- c.-117C>G Single submitter ⚠
- c.-117C>T Single submitter ⚠
- c.-118G>T Single submitter ⚠
- c.-12C>T Single submitter ⚠
- c.-17G>C Single submitter ⚠
- c.-29C>T Single submitter ⚠
- c.-2A>T Single submitter ⚠
- c.-30G>A Single submitter ⚠
- c.-36G>A Single submitter ⚠
- c.-56C>T Single submitter ⚠
- c.-72C>T Single submitter ⚠
- c.-77C>T Single submitter ⚠
- c.-83T>C Single submitter ⚠
- c.-84T>G Single submitter ⚠
- c.-86G>A Single submitter ⚠
- c.-98G>C Single submitter ⚠
- c.-99C>T Single submitter
- p.Ala306Thr Single submitter ⚠
- p.Arg304Pro Single submitter ⚠
- p.Arg309Gly Single submitter ⚠
- p.Arg98Cys Single submitter
- p.Arg98His Single submitter
- p.Cys152Arg Single submitter ⚠
- p.Cys164Gly Single submitter
- p.Gln200Arg Single submitter ⚠
- p.Gln245His Single submitter ⚠
- p.Gly27Arg Single submitter ⚠
- p.Gly28Arg Single submitter ⚠
- p.His223Arg Single submitter ⚠
- p.His278Arg Single submitter ⚠
- p.Ile179Val Single submitter
- p.Ile196Val Single submitter ⚠
- p.Leu279Phe Single submitter ⚠
- p.Leu57Met Single submitter
- p.Lys234Ile Single submitter ⚠
- p.Met45Val Single submitter ⚠
- p.Pro250Leu Single submitter ⚠
- p.Pro314Arg Single submitter ⚠
- p.Ser303Ile Single submitter ⚠
- p.Ser72Tyr Single submitter
- p.Tyr239Cys Single submitter ⚠