DUSP12 — 54 ClinVar variants
All ClinVar germline DUSP12 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
4 Likely benign · 50 Uncertain significance
Full DUSP12 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DUSP12 p.Ala167Val Uncertain significance Single submitter
- DUSP12 p.Arg20Ser Uncertain significance Single submitter
- DUSP12 p.Arg222Ser Uncertain significance Single submitter
- DUSP12 p.Arg238Cys Uncertain significance Single submitter
- DUSP12 p.Arg77His Uncertain significance Single submitter
- DUSP12 p.Asp9Asn Uncertain significance Single submitter
- DUSP12 p.Gln306Arg Uncertain significance Single submitter
- DUSP12 p.Glu139Val Uncertain significance Single submitter
- DUSP12 p.Glu63Lys Uncertain significance Single submitter
- DUSP12 p.Gly102Val Uncertain significance Single submitter
- DUSP12 p.Gly25Ala Uncertain significance Single submitter
- DUSP12 p.Gly25Glu Uncertain significance Single submitter
- DUSP12 p.Gly334Glu Uncertain significance Single submitter
- DUSP12 p.Gly33Arg Uncertain significance Single submitter
- DUSP12 p.His114Asp Uncertain significance Single submitter
- DUSP12 p.His248Arg Uncertain significance Single submitter
- DUSP12 p.His47Asn Uncertain significance Single submitter
- DUSP12 p.Ile101Val Uncertain significance Single submitter
- DUSP12 p.Leu184Phe Uncertain significance Single submitter
- DUSP12 p.Leu289Ile Uncertain significance Single submitter
- DUSP12 p.Leu289Phe Uncertain significance Single submitter
- DUSP12 p.Leu330Phe Uncertain significance Single submitter
- DUSP12 p.Lys132Thr Uncertain significance Single submitter
- DUSP12 p.Lys249Arg Uncertain significance Single submitter
- DUSP12 p.Lys249Gln Uncertain significance Single submitter
- DUSP12 p.Met276Val Uncertain significance Single submitter
- DUSP12 p.Met27Lys Uncertain significance Single submitter
- DUSP12 p.Pro16Arg Uncertain significance Single submitter
- DUSP12 p.Pro16Ser Uncertain significance Single submitter
- DUSP12 p.Pro243Ser Uncertain significance Single submitter
- DUSP12 p.Pro331Ser Uncertain significance Single submitter
- DUSP12 p.Pro5Leu Uncertain significance Single submitter
- DUSP12 p.Pro64Leu Uncertain significance Single submitter
- DUSP12 p.Thr252Ala Uncertain significance Single submitter
- DUSP12 p.Thr314Ala Uncertain significance Single submitter
- DUSP12 p.Tyr179His Uncertain significance Single submitter
- DUSP12 p.Val187Leu Uncertain significance Single submitter
- DUSP12 p.Val80Ala Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- DUSP12 p.Glu107Val Uncertain significance Single submitter
- DUSP12 p.Glu62Lys Uncertain significance Single submitter
- DUSP12 p.Glu87Lys Uncertain significance Single submitter
- DUSP12 p.His248Pro Uncertain significance Single submitter
- DUSP12 p.Ile101Thr Uncertain significance Single submitter
- DUSP12 p.Pro192Ala Uncertain significance Single submitter
- DUSP12 p.Ser232Pro Uncertain significance Single submitter
- DUSP12 p.Thr58Ala Uncertain significance Single submitter
- DUSP12 p.Tyr182His Uncertain significance Single submitter
- DUSP12 p.Val111Leu Uncertain significance Single submitter
- DUSP12 p.Val56Met Uncertain significance Single submitter
All DUSP12 variants
Likely benign 4
- p.Arg238His Single submitter
- p.Cys23Ser Single submitter
- p.Ser22Thr Single submitter
- p.Tyr170Cys Single submitter
Uncertain significance 50
- p.Ala167Val Single submitter ⚠
- p.Arg20Ser Single submitter ⚠
- p.Arg222Ser Single submitter ⚠
- p.Arg238Cys Single submitter ⚠
- p.Arg77His Single submitter ⚠
- p.Asp9Asn Single submitter ⚠
- p.Gln306Arg Single submitter ⚠
- p.Glu107Val Single submitter ⚠
- p.Glu139Val Single submitter ⚠
- p.Glu62Lys Single submitter ⚠
- p.Glu63Lys Single submitter ⚠
- p.Glu87Lys Single submitter ⚠
- p.Gly102Val Single submitter ⚠
- p.Gly25Ala Single submitter ⚠
- p.Gly25Glu Single submitter ⚠
- p.Gly334Glu Single submitter ⚠
- p.Gly33Arg Single submitter ⚠
- p.Gly38Arg Single submitter
- p.His114Asp Single submitter ⚠
- p.His248Arg Single submitter ⚠
- p.His248Pro Single submitter ⚠
- p.His47Asn Single submitter ⚠
- p.Ile101Thr Single submitter ⚠
- p.Ile101Val Single submitter ⚠
- p.Leu184Phe Single submitter ⚠
- p.Leu289Ile Single submitter ⚠
- p.Leu289Phe Single submitter ⚠
- p.Leu330Phe Single submitter ⚠
- p.Lys132Thr Single submitter ⚠
- p.Lys249Arg Single submitter ⚠
- p.Lys249Gln Single submitter ⚠
- p.Met276Val Single submitter ⚠
- p.Met27Lys Single submitter ⚠
- p.Pro16Arg Single submitter ⚠
- p.Pro16Ser Single submitter ⚠
- p.Pro192Ala Single submitter ⚠
- p.Pro243Ser Single submitter ⚠
- p.Pro331Ser Single submitter ⚠
- p.Pro5Leu Single submitter ⚠
- p.Pro64Leu Single submitter ⚠
- p.Ser232Pro Single submitter ⚠
- p.Thr252Ala Single submitter ⚠
- p.Thr314Ala Single submitter ⚠
- p.Thr58Ala Single submitter ⚠
- p.Tyr179His Single submitter ⚠
- p.Tyr182His Single submitter ⚠
- p.Val111Leu Single submitter ⚠
- p.Val187Leu Single submitter ⚠
- p.Val56Met Single submitter ⚠
- p.Val80Ala Single submitter ⚠