DUSP15 — 51 ClinVar variants
All ClinVar germline DUSP15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 11 flagged for review →
1 Likely benign · 50 Uncertain significance
Full DUSP15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 11
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DUSP15 p.Arg78His Uncertain significance Single submitter
- DUSP15 p.Asp47Gly Uncertain significance Single submitter
- DUSP15 p.Cys70Arg Uncertain significance Single submitter
- DUSP15 p.Gly15Arg Uncertain significance Single submitter
- DUSP15 p.Pro129Ser Uncertain significance Single submitter
- DUSP15 p.Thr58Ser Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All DUSP15 variants
Likely benign 1
- p.Ser184Ala Single submitter
Uncertain significance 50
- p.Ala191Pro Single submitter
- p.Ala192Pro Single submitter
- p.Arg148Gln Single submitter
- p.Arg166Ser Single submitter
- p.Arg174Cys Single submitter
- p.Arg174His Single submitter
- p.Arg176Pro Single submitter
- p.Arg176Trp Single submitter
- p.Arg199Leu Single submitter
- p.Arg203Ser Single submitter
- p.Arg206Gly Single submitter
- p.Arg206Trp Single submitter
- p.Arg217Ser Single submitter
- p.Arg227Gln Single submitter
- p.Arg78His Single submitter ⚠
- p.Asn29Lys Single submitter ⚠
- p.Asp47Gly Single submitter ⚠
- p.Cys172Gly Single submitter
- p.Cys70Arg Single submitter ⚠
- p.Cys70Gly Single submitter ⚠
- p.Gln220Pro Single submitter
- p.Glu151Asp Single submitter
- p.Glu156Gln Single submitter
- p.Glu156Gly Single submitter
- p.Glu194Gln Single submitter
- p.Gly139Asp Single submitter ⚠
- p.Gly155Arg Single submitter
- p.Gly15Arg Single submitter ⚠
- p.His189Tyr Single submitter
- p.Ile18Thr Single submitter ⚠
- p.Ile35Phe Single submitter ⚠
- p.Ile98fs Single submitter
- p.Leu14Val Single submitter
- p.Leu169Pro Single submitter
- p.Lys235Arg Single submitter
- p.Phe222Tyr Single submitter
- p.Pro129Ser Single submitter ⚠
- p.Pro170Leu Single submitter
- p.Pro202Ser Single submitter
- p.Pro205Arg Single submitter
- p.Pro205Ser Single submitter
- p.Pro211Gln Single submitter
- p.Ser179Ala Single submitter
- p.Ser179Phe Single submitter
- p.Ser182Leu Single submitter
- p.Ser193Phe Single submitter
- p.Thr181Ile Single submitter
- p.Thr196Ile Single submitter
- p.Thr58Ser Single submitter ⚠
- p.Val201Met Single submitter