DUSP18 — 36 ClinVar variants
All ClinVar germline DUSP18 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
2 Likely benign · 34 Uncertain significance
Full DUSP18 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DUSP18 p.Ala124Thr Uncertain significance Single submitter
- DUSP18 p.Ala130Val Uncertain significance Single submitter
- DUSP18 p.Ala7Ser Uncertain significance Single submitter
- DUSP18 p.Arg138Trp Uncertain significance Single submitter
- DUSP18 p.Arg13Gln Uncertain significance Single submitter
- DUSP18 p.Arg13Trp Uncertain significance Single submitter
- DUSP18 p.Arg183Cys Uncertain significance Single submitter
- DUSP18 p.Arg78Cys Uncertain significance Single submitter
- DUSP18 p.Asn51Ser Uncertain significance Single submitter
- DUSP18 p.Cys6Tyr Uncertain significance Single submitter
- DUSP18 p.Gln45Arg Uncertain significance Single submitter
- DUSP18 p.Gln68Glu Uncertain significance Single submitter
- DUSP18 p.Gly160Ser Uncertain significance Single submitter
- DUSP18 p.His165Tyr Uncertain significance Single submitter
- DUSP18 p.Ile50Val Uncertain significance Single submitter
- DUSP18 p.Leu101Trp Uncertain significance Single submitter
- DUSP18 p.Leu188Pro Uncertain significance Single submitter
- DUSP18 p.Leu79Val Uncertain significance Single submitter
- DUSP18 p.Lys161Thr Uncertain significance Single submitter
- DUSP18 p.Lys180Asn Uncertain significance Single submitter
- DUSP18 p.Met120Ile Uncertain significance Single submitter
- DUSP18 p.Met185Ile Uncertain significance Single submitter
- DUSP18 p.Ser5Leu Uncertain significance Single submitter
- DUSP18 p.Ser74Phe Uncertain significance Single submitter
- DUSP18 p.Val93Met Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- DUSP18 p.Arg142Gln Uncertain significance Single submitter
- DUSP18 p.Arg99His Uncertain significance Single submitter
- DUSP18 p.Ile177Met Uncertain significance Single submitter
- DUSP18 p.Phe82Ile Uncertain significance Single submitter
- DUSP18 p.Thr163Ala Uncertain significance Single submitter
- DUSP18 p.Val164Leu Uncertain significance Single submitter
All DUSP18 variants
Likely benign 2
- p.Met67Val Single submitter
- p.Val164fs Single submitter
Uncertain significance 34
- p.Ala124Thr Single submitter ⚠
- p.Ala130Val Single submitter ⚠
- p.Ala7Ser Single submitter ⚠
- p.Arg138Trp Single submitter ⚠
- p.Arg13Gln Single submitter ⚠
- p.Arg13Trp Single submitter ⚠
- p.Arg142Gln Single submitter ⚠
- p.Arg183Cys Single submitter ⚠
- p.Arg78Cys Single submitter ⚠
- p.Arg99His Single submitter ⚠
- p.Asn51Ser Single submitter ⚠
- p.Cys6Tyr Single submitter ⚠
- p.Gln45Arg Single submitter ⚠
- p.Gln68Glu Single submitter ⚠
- p.Gly160Ser Single submitter ⚠
- p.His165Tyr Single submitter ⚠
- p.Ile177Met Single submitter ⚠
- p.Ile50Val Single submitter ⚠
- p.Leu101Trp Single submitter ⚠
- p.Leu158Phe Single submitter
- p.Leu188Pro Single submitter ⚠
- p.Leu79Val Single submitter ⚠
- p.Lys161Thr Single submitter ⚠
- p.Lys180Asn Single submitter ⚠
- p.Met120Ile Single submitter ⚠
- p.Met185Ile Single submitter ⚠
- p.Phe82Ile Single submitter ⚠
- p.Ser21Leu Single submitter
- p.Ser5Leu Single submitter ⚠
- p.Ser74Phe Single submitter ⚠
- p.Thr163Ala Single submitter ⚠
- p.Tyr178Cys Single submitter
- p.Val164Leu Single submitter ⚠
- p.Val93Met Single submitter ⚠