DUSP23 — 34 ClinVar variants
All ClinVar germline DUSP23 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
34 Uncertain significance
Full DUSP23 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DUSP23 p.Arg114Gln Uncertain significance Single submitter
- DUSP23 p.Arg129Pro Uncertain significance Single submitter
- DUSP23 p.Arg87Leu Uncertain significance Single submitter
- DUSP23 p.Asn7Thr Uncertain significance Single submitter
- DUSP23 p.Asn85Ser Uncertain significance Single submitter
- DUSP23 p.Cys67Arg Uncertain significance Single submitter
- DUSP23 p.Cys67Phe Uncertain significance Single submitter
- DUSP23 p.Gln138Arg Uncertain significance Single submitter
- DUSP23 p.Gly55Ser Uncertain significance Single submitter
- DUSP23 p.Gly88Arg Uncertain significance Single submitter
- DUSP23 p.His49Tyr Uncertain significance Single submitter
- DUSP23 p.Ile122Val Uncertain significance Single submitter
- DUSP23 p.Ile80Ser Uncertain significance Single submitter
- DUSP23 p.Leu12Ile Uncertain significance Single submitter
- DUSP23 p.Leu34Val Uncertain significance Single submitter
- DUSP23 p.Pro68Ser Uncertain significance Single submitter
- DUSP23 p.Pro69Ser Uncertain significance Single submitter
- DUSP23 p.Ser52Gly Uncertain significance Single submitter
- DUSP23 p.Thr102Pro Uncertain significance Single submitter
- DUSP23 p.Thr104Ile Uncertain significance Single submitter
- DUSP23 p.Trp10Cys Uncertain significance Single submitter
- DUSP23 p.Tyr146Cys Uncertain significance Single submitter
- DUSP23 p.Val36Glu Uncertain significance Single submitter
- DUSP23 p.Val93Met Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- DUSP23 p.Arg87Trp Uncertain significance Single submitter
- DUSP23 p.Gly115Asp Uncertain significance Single submitter
- DUSP23 p.Gly115Val Uncertain significance Single submitter
- DUSP23 p.Gly92Glu Uncertain significance Single submitter
- DUSP23 p.Leu56Val Uncertain significance Single submitter
- DUSP23 p.Pro5Ser Uncertain significance Single submitter
All DUSP23 variants
Uncertain significance 34
- p.Arg114Gln Single submitter ⚠
- p.Arg129Pro Single submitter ⚠
- p.Arg87Leu Single submitter ⚠
- p.Arg87Trp Single submitter ⚠
- p.Asn7Thr Single submitter ⚠
- p.Asn85Ser Single submitter ⚠
- p.Cys67Arg Single submitter ⚠
- p.Cys67Phe Single submitter ⚠
- p.Gln138Arg Single submitter ⚠
- p.Gly115Asp Single submitter ⚠
- p.Gly115Val Single submitter ⚠
- p.Gly55Ser Single submitter ⚠
- p.Gly88Arg Single submitter ⚠
- p.Gly92Glu Single submitter ⚠
- p.His49Tyr Single submitter ⚠
- p.His59Gln Single submitter
- p.His59Leu Single submitter
- p.Ile122Val Single submitter ⚠
- p.Ile80Ser Single submitter ⚠
- p.Leu12Ile Single submitter ⚠
- p.Leu34Val Single submitter ⚠
- p.Leu56Val Single submitter ⚠
- p.Phe99Cys Single submitter
- p.Pro5Ser Single submitter ⚠
- p.Pro68Leu Single submitter
- p.Pro68Ser Single submitter ⚠
- p.Pro69Ser Single submitter ⚠
- p.Ser52Gly Single submitter ⚠
- p.Thr102Pro Single submitter ⚠
- p.Thr104Ile Single submitter ⚠
- p.Trp10Cys Single submitter ⚠
- p.Tyr146Cys Single submitter ⚠
- p.Val36Glu Single submitter ⚠
- p.Val93Met Single submitter ⚠