DUSP28 — 54 ClinVar variants
All ClinVar germline DUSP28 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
54 Uncertain significance
Full DUSP28 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DUSP28 p.Ala112Thr Uncertain significance Single submitter
- DUSP28 p.Ala116Val Uncertain significance Single submitter
- DUSP28 p.Ala127Glu Uncertain significance Single submitter
- DUSP28 p.Ala129Pro Uncertain significance Single submitter
- DUSP28 p.Ala41Gly Uncertain significance Single submitter
- DUSP28 p.Arg120Pro Uncertain significance Single submitter
- DUSP28 p.Asp72Asn Uncertain significance Single submitter
- DUSP28 p.Cys114Tyr Uncertain significance Single submitter
- DUSP28 p.Cys99Tyr Uncertain significance Single submitter
- DUSP28 p.Gln131Arg Uncertain significance Single submitter
- DUSP28 p.Gln55Lys Uncertain significance Single submitter
- DUSP28 p.Glu155Ala Uncertain significance Single submitter
- DUSP28 p.Gly29Arg Uncertain significance Single submitter
- DUSP28 p.Gly7Arg Uncertain significance Single submitter
- DUSP28 p.Leu150Phe Uncertain significance Single submitter
- DUSP28 p.Leu172Ser Uncertain significance Single submitter
- DUSP28 p.Met119Lys Uncertain significance Single submitter
- DUSP28 p.Met132Ile Uncertain significance Single submitter
- DUSP28 p.Met89Ile Uncertain significance Single submitter
- DUSP28 p.Met89Thr Uncertain significance Single submitter
- DUSP28 p.Phe130Ser Uncertain significance Single submitter
- DUSP28 p.Ser13Leu Uncertain significance Single submitter
- DUSP28 p.Trp147Gly Uncertain significance Single submitter
- DUSP28 p.Val133Met Uncertain significance Single submitter
- DUSP28 p.Val45Leu Uncertain significance Single submitter
- DUSP28 p.Val49Asp Uncertain significance Single submitter
- DUSP28 p.Val70Met Uncertain significance Single submitter
Predictors split 27
The independent predictors disagree with each other — read with care.
- DUSP28 p.Ala12Thr Uncertain significance Single submitter
- DUSP28 p.Ala136Ser Uncertain significance Single submitter
- DUSP28 p.Ala60Thr Uncertain significance Single submitter
- DUSP28 p.Ala6Val Uncertain significance Single submitter
- DUSP28 p.Ala91Thr Uncertain significance Single submitter
- DUSP28 p.Ala91Val Uncertain significance Single submitter
- DUSP28 p.Arg120Gln Uncertain significance Single submitter
- DUSP28 p.Arg122Cys Uncertain significance Single submitter
- DUSP28 p.Asn105Lys Uncertain significance Single submitter
- DUSP28 p.Asp73His Uncertain significance Single submitter
- DUSP28 p.Asp77Asn Uncertain significance Single submitter
- DUSP28 p.Glu154Gln Uncertain significance Single submitter
- DUSP28 p.Leu118Val Uncertain significance Single submitter
- DUSP28 p.Leu163Pro Uncertain significance Single submitter
- DUSP28 p.Leu79Pro Uncertain significance Single submitter
- DUSP28 p.Pro18Gln Uncertain significance Single submitter
- DUSP28 p.Pro18Thr Uncertain significance Single submitter
- DUSP28 p.Pro24Thr Uncertain significance Single submitter
- DUSP28 p.Pro61Ser Uncertain significance Single submitter
- DUSP28 p.Pro84Ala Uncertain significance Single submitter
- DUSP28 p.Pro84Ser Uncertain significance Single submitter
- DUSP28 p.Ser13Trp Uncertain significance Single submitter
- DUSP28 p.Ser148Phe Uncertain significance Single submitter
- DUSP28 p.Ser161Phe Uncertain significance Single submitter
- DUSP28 p.Thr115Ile Uncertain significance Single submitter
- DUSP28 p.Tyr117Phe Uncertain significance Single submitter
- DUSP28 p.Val113Leu Uncertain significance Single submitter
All DUSP28 variants
Uncertain significance 54
- p.Ala112Thr Single submitter ⚠
- p.Ala116Val Single submitter ⚠
- p.Ala127Glu Single submitter ⚠
- p.Ala129Pro Single submitter ⚠
- p.Ala12Thr Single submitter ⚠
- p.Ala136Ser Single submitter ⚠
- p.Ala41Gly Single submitter ⚠
- p.Ala60Thr Single submitter ⚠
- p.Ala6Val Single submitter ⚠
- p.Ala91Thr Single submitter ⚠
- p.Ala91Val Single submitter ⚠
- p.Arg120Gln Single submitter ⚠
- p.Arg120Pro Single submitter ⚠
- p.Arg122Cys Single submitter ⚠
- p.Asn105Lys Single submitter ⚠
- p.Asp72Asn Single submitter ⚠
- p.Asp73His Single submitter ⚠
- p.Asp77Asn Single submitter ⚠
- p.Cys114Tyr Single submitter ⚠
- p.Cys99Tyr Single submitter ⚠
- p.Gln131Arg Single submitter ⚠
- p.Gln55Lys Single submitter ⚠
- p.Glu154Gln Single submitter ⚠
- p.Glu155Ala Single submitter ⚠
- p.Gly29Arg Single submitter ⚠
- p.Gly7Arg Single submitter ⚠
- p.Leu118Val Single submitter ⚠
- p.Leu150Phe Single submitter ⚠
- p.Leu163Pro Single submitter ⚠
- p.Leu172Ser Single submitter ⚠
- p.Leu79Pro Single submitter ⚠
- p.Met119Lys Single submitter ⚠
- p.Met132Ile Single submitter ⚠
- p.Met89Ile Single submitter ⚠
- p.Met89Thr Single submitter ⚠
- p.Phe130Ser Single submitter ⚠
- p.Pro18Gln Single submitter ⚠
- p.Pro18Thr Single submitter ⚠
- p.Pro24Thr Single submitter ⚠
- p.Pro61Ser Single submitter ⚠
- p.Pro84Ala Single submitter ⚠
- p.Pro84Ser Single submitter ⚠
- p.Ser13Leu Single submitter ⚠
- p.Ser13Trp Single submitter ⚠
- p.Ser148Phe Single submitter ⚠
- p.Ser161Phe Single submitter ⚠
- p.Thr115Ile Single submitter ⚠
- p.Trp147Gly Single submitter ⚠
- p.Tyr117Phe Single submitter ⚠
- p.Val113Leu Single submitter ⚠
- p.Val133Met Single submitter ⚠
- p.Val45Leu Single submitter ⚠
- p.Val49Asp Single submitter ⚠
- p.Val70Met Single submitter ⚠