DUSP8 — 106 ClinVar variants
All ClinVar germline DUSP8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 104 flagged for review →
1 Benign · 1 Likely benign · 104 Uncertain significance
Full DUSP8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 104
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 65
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DUSP8 p.Ala272Ser Uncertain significance Single submitter
- DUSP8 p.Ala305Thr Uncertain significance Single submitter
- DUSP8 p.Ala325Pro Uncertain significance Single submitter
- DUSP8 p.Ala403Val Uncertain significance Single submitter
- DUSP8 p.Ala461Ser Uncertain significance Single submitter
- DUSP8 p.Ala493Thr Uncertain significance Single submitter
- DUSP8 p.Ala601Pro Uncertain significance Single submitter
- DUSP8 p.Ala80Ser Uncertain significance Single submitter
- DUSP8 p.Arg450Gly Uncertain significance Single submitter
- DUSP8 p.Arg455Leu Uncertain significance Single submitter
- DUSP8 p.Arg544Gln Uncertain significance Single submitter
- DUSP8 p.Arg567Gln Uncertain significance Single submitter
- DUSP8 p.Arg58Leu Uncertain significance Single submitter
- DUSP8 p.Arg5Gln Uncertain significance Single submitter
- DUSP8 p.Arg602Pro Uncertain significance Single submitter
- DUSP8 p.Asn192Ser Uncertain significance Single submitter
- DUSP8 p.Asn388His Uncertain significance Single submitter
- DUSP8 p.Asp12Glu Uncertain significance Single submitter
- DUSP8 p.Asp270Asn Uncertain significance Single submitter
- DUSP8 p.Asp309Ala Uncertain significance Single submitter
- DUSP8 p.Asp309Glu Uncertain significance Single submitter
- DUSP8 p.Asp568Glu Uncertain significance Single submitter
- DUSP8 p.Cys137Trp Uncertain significance Single submitter
- DUSP8 p.Gln241Arg Uncertain significance Single submitter
- DUSP8 p.Glu205Asp Uncertain significance Single submitter
- DUSP8 p.Glu529Gln Uncertain significance Single submitter
- DUSP8 p.Gly22Asp Uncertain significance Single submitter
- DUSP8 p.Gly22Cys Uncertain significance Single submitter
- DUSP8 p.Gly326Arg Uncertain significance Single submitter
- DUSP8 p.Gly355Ser Uncertain significance Single submitter
- DUSP8 p.Gly356Arg Uncertain significance Single submitter
- DUSP8 p.Gly410Asp Uncertain significance Single submitter
- DUSP8 p.Gly417Ser Uncertain significance Single submitter
- DUSP8 p.Gly473Arg Uncertain significance Single submitter
- DUSP8 p.Gly495Arg Uncertain significance Single submitter
- DUSP8 p.Gly536Arg Uncertain significance Single submitter
- DUSP8 p.Gly553Ser Uncertain significance Single submitter
- DUSP8 p.Gly572Ser Uncertain significance Single submitter
- DUSP8 p.His167Tyr Uncertain significance Single submitter
- DUSP8 p.His486Gln Uncertain significance Single submitter
- DUSP8 p.Ile213Val Uncertain significance Single submitter
- DUSP8 p.Leu144Val Uncertain significance Single submitter
- DUSP8 p.Leu384Gln Uncertain significance Single submitter
- DUSP8 p.Leu472Arg Uncertain significance Single submitter
- DUSP8 p.Met209Thr Uncertain significance Single submitter
- DUSP8 p.Pro223Thr Uncertain significance Single submitter
- DUSP8 p.Pro281Arg Uncertain significance Single submitter
- DUSP8 p.Pro408Leu Uncertain significance Single submitter
- DUSP8 p.Pro420Arg Uncertain significance Single submitter
- DUSP8 p.Pro428Leu Uncertain significance Single submitter
- DUSP8 p.Pro440Leu Uncertain significance Single submitter
- DUSP8 p.Pro460Arg Uncertain significance Single submitter
- DUSP8 p.Pro497Ser Uncertain significance Single submitter
- DUSP8 p.Pro502Arg Uncertain significance Single submitter
- DUSP8 p.Pro510Leu Uncertain significance Single submitter
- DUSP8 p.Pro511Ser Uncertain significance Single submitter
- DUSP8 p.Pro523Ser Uncertain significance Single submitter
- DUSP8 p.Pro566Ala Uncertain significance Single submitter
- DUSP8 p.Pro566Ser Uncertain significance Single submitter
- DUSP8 p.Pro579Leu Uncertain significance Single submitter
- DUSP8 p.Ser18Gly Uncertain significance Single submitter
- DUSP8 p.Ser400Thr Uncertain significance Single submitter
- DUSP8 p.Thr336Pro Uncertain significance Single submitter
- DUSP8 p.Thr363Lys Uncertain significance Single submitter
- DUSP8 p.Val190Phe Uncertain significance Single submitter
Predictors split 39
The independent predictors disagree with each other — read with care.
- DUSP8 p.Ala101Thr Uncertain significance Single submitter
- DUSP8 p.Ala345Val Uncertain significance Single submitter
- DUSP8 p.Ala366Val Uncertain significance Single submitter
- DUSP8 p.Ala445Thr Uncertain significance Single submitter
- DUSP8 p.Ala449Val Uncertain significance Single submitter
- DUSP8 p.Ala465Thr Uncertain significance Single submitter
- DUSP8 p.Ala480Val Uncertain significance Single submitter
- DUSP8 p.Ala96Thr Uncertain significance Single submitter
- DUSP8 p.Arg298His Uncertain significance Single submitter
- DUSP8 p.Arg375His Uncertain significance Single submitter
- DUSP8 p.Arg452Trp Uncertain significance Single submitter
- DUSP8 p.Arg454His Uncertain significance Single submitter
- DUSP8 p.Arg466Cys Uncertain significance Single submitter
- DUSP8 p.Arg75His Uncertain significance Single submitter
- DUSP8 p.Asp409Asn Uncertain significance Single submitter
- DUSP8 p.Asp415Asn Uncertain significance Single submitter
- DUSP8 p.Cys51Ser Uncertain significance Single submitter
- DUSP8 p.Glu357Lys Uncertain significance Single submitter
- DUSP8 p.Gly315Glu Uncertain significance Single submitter
- DUSP8 p.Gly434Cys Uncertain significance Single submitter
- DUSP8 p.Leu300Val Uncertain significance Single submitter
- DUSP8 p.Leu352Met Uncertain significance Single submitter
- DUSP8 p.Leu472Phe Uncertain significance Single submitter
- DUSP8 p.Leu512Phe Uncertain significance Single submitter
- DUSP8 p.Leu69Ile Uncertain significance Single submitter
- DUSP8 p.Lys301Thr Uncertain significance Single submitter
- DUSP8 p.Pro313Leu Uncertain significance Single submitter
- DUSP8 p.Pro328Arg Uncertain significance Single submitter
- DUSP8 p.Pro443Leu Uncertain significance Single submitter
- DUSP8 p.Pro464Leu Uncertain significance Single submitter
- DUSP8 p.Ser32Thr Uncertain significance Single submitter
- DUSP8 p.Ser439Cys Uncertain significance Single submitter
- DUSP8 p.Ser463Phe Uncertain significance Single submitter
- DUSP8 p.Ser467Tyr Uncertain significance Single submitter
- DUSP8 p.Ser514Phe Uncertain significance Single submitter
- DUSP8 p.Thr183Met Uncertain significance Single submitter
- DUSP8 p.Thr93Met Uncertain significance Single submitter
- DUSP8 p.Val537Met Uncertain significance Single submitter
- DUSP8 p.Val86Met Uncertain significance Single submitter
All DUSP8 variants
Benign 1
- p.Asp271= Multiple submitters
Likely benign 1
- p.Pro320Leu Single submitter
Uncertain significance 104
- p.Ala101Thr Single submitter ⚠
- p.Ala272Ser Single submitter ⚠
- p.Ala305Thr Single submitter ⚠
- p.Ala325Pro Single submitter ⚠
- p.Ala345Val Single submitter ⚠
- p.Ala366Val Single submitter ⚠
- p.Ala403Val Single submitter ⚠
- p.Ala445Thr Single submitter ⚠
- p.Ala449Val Single submitter ⚠
- p.Ala461Ser Single submitter ⚠
- p.Ala465Thr Single submitter ⚠
- p.Ala480Val Single submitter ⚠
- p.Ala493Thr Single submitter ⚠
- p.Ala601Pro Single submitter ⚠
- p.Ala80Ser Single submitter ⚠
- p.Ala96Thr Single submitter ⚠
- p.Arg298His Single submitter ⚠
- p.Arg375His Single submitter ⚠
- p.Arg450Gly Single submitter ⚠
- p.Arg452Trp Single submitter ⚠
- p.Arg454His Single submitter ⚠
- p.Arg455Leu Single submitter ⚠
- p.Arg466Cys Single submitter ⚠
- p.Arg544Gln Single submitter ⚠
- p.Arg567Gln Single submitter ⚠
- p.Arg58Leu Single submitter ⚠
- p.Arg5Gln Single submitter ⚠
- p.Arg602Pro Single submitter ⚠
- p.Arg75His Single submitter ⚠
- p.Asn192Ser Single submitter ⚠
- p.Asn388His Single submitter ⚠
- p.Asp12Glu Single submitter ⚠
- p.Asp270Asn Single submitter ⚠
- p.Asp309Ala Single submitter ⚠
- p.Asp309Glu Single submitter ⚠
- p.Asp409Asn Single submitter ⚠
- p.Asp415Asn Single submitter ⚠
- p.Asp568Glu Single submitter ⚠
- p.Cys137Trp Single submitter ⚠
- p.Cys51Ser Single submitter ⚠
- p.Gln241Arg Single submitter ⚠
- p.Glu205Asp Single submitter ⚠
- p.Glu357Lys Single submitter ⚠
- p.Glu529Gln Single submitter ⚠
- p.Gly22Asp Single submitter ⚠
- p.Gly22Cys Single submitter ⚠
- p.Gly315Glu Single submitter ⚠
- p.Gly326Arg Single submitter ⚠
- p.Gly355Ser Single submitter ⚠
- p.Gly356Arg Single submitter ⚠
- p.Gly410Asp Single submitter ⚠
- p.Gly417Ser Single submitter ⚠
- p.Gly434Cys Single submitter ⚠
- p.Gly473Arg Single submitter ⚠
- p.Gly495Arg Single submitter ⚠
- p.Gly536Arg Single submitter ⚠
- p.Gly553Ser Single submitter ⚠
- p.Gly572Ser Single submitter ⚠
- p.His167Tyr Single submitter ⚠
- p.His486Gln Single submitter ⚠
- p.Ile213Val Single submitter ⚠
- p.Leu144Val Single submitter ⚠
- p.Leu300Val Single submitter ⚠
- p.Leu352Met Single submitter ⚠
- p.Leu384Gln Single submitter ⚠
- p.Leu472Arg Single submitter ⚠
- p.Leu472Phe Single submitter ⚠
- p.Leu512Phe Single submitter ⚠
- p.Leu69Ile Single submitter ⚠
- p.Lys301Thr Single submitter ⚠
- p.Met209Thr Single submitter ⚠
- p.Pro223Thr Single submitter ⚠
- p.Pro281Arg Single submitter ⚠
- p.Pro313Leu Single submitter ⚠
- p.Pro328Arg Single submitter ⚠
- p.Pro408Leu Single submitter ⚠
- p.Pro420Arg Single submitter ⚠
- p.Pro428Leu Single submitter ⚠
- p.Pro440Leu Single submitter ⚠
- p.Pro443Leu Single submitter ⚠
- p.Pro460Arg Single submitter ⚠
- p.Pro464Leu Single submitter ⚠
- p.Pro497Ser Single submitter ⚠
- p.Pro502Arg Single submitter ⚠
- p.Pro510Leu Single submitter ⚠
- p.Pro511Ser Single submitter ⚠
- p.Pro523Ser Single submitter ⚠
- p.Pro566Ala Single submitter ⚠
- p.Pro566Ser Single submitter ⚠
- p.Pro579Leu Single submitter ⚠
- p.Ser18Gly Single submitter ⚠
- p.Ser32Thr Single submitter ⚠
- p.Ser400Thr Single submitter ⚠
- p.Ser439Cys Single submitter ⚠
- p.Ser463Phe Single submitter ⚠
- p.Ser467Tyr Single submitter ⚠
- p.Ser514Phe Single submitter ⚠
- p.Thr183Met Single submitter ⚠
- p.Thr336Pro Single submitter ⚠
- p.Thr363Lys Single submitter ⚠
- p.Thr93Met Single submitter ⚠
- p.Val190Phe Single submitter ⚠
- p.Val537Met Single submitter ⚠
- p.Val86Met Single submitter ⚠