DYNAP — 33 ClinVar variants
All ClinVar germline DYNAP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
3 Likely benign · 30 Uncertain significance
Full DYNAP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DYNAP c.13A>C Uncertain significance Single submitter
- DYNAP c.20G>A Uncertain significance Single submitter
- DYNAP c.28C>A Uncertain significance Single submitter
- DYNAP c.-29G>C Uncertain significance Single submitter
- DYNAP p.Ala169Thr Uncertain significance Single submitter
- DYNAP p.Ala29Pro Uncertain significance Single submitter
- DYNAP p.Arg80His Uncertain significance Single submitter
- DYNAP p.Asp2Glu Uncertain significance Single submitter
- DYNAP p.Cys108Ser Uncertain significance Single submitter
- DYNAP p.Cys65Phe Uncertain significance Single submitter
- DYNAP p.Glu16Asp Uncertain significance Single submitter
- DYNAP p.Gly52Ala Uncertain significance Single submitter
- DYNAP p.Gly6Arg Uncertain significance Single submitter
- DYNAP p.Gly6Glu Uncertain significance Single submitter
- DYNAP p.Ile107Leu Uncertain significance Single submitter
- DYNAP p.Ile21Val Uncertain significance Single submitter
- DYNAP p.Leu60Phe Uncertain significance Single submitter
- DYNAP p.Leu93Phe Uncertain significance Single submitter
- DYNAP p.Leu94Val Uncertain significance Single submitter
- DYNAP p.Pro19Leu Uncertain significance Single submitter
- DYNAP p.Thr100Arg Uncertain significance Single submitter
- DYNAP p.Thr159Ala Uncertain significance Single submitter
- DYNAP p.Trp83Arg Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- DYNAP p.Ala158Asp Uncertain significance Single submitter
- DYNAP p.Glu160Gln Uncertain significance Single submitter
- DYNAP p.Ser115Leu Uncertain significance Single submitter
- DYNAP p.Thr149Ala Uncertain significance Single submitter
- DYNAP p.Thr162Ile Uncertain significance Single submitter
- DYNAP p.Thr171Ala Uncertain significance Single submitter
- DYNAP p.Val55Met Likely benign Single submitter
All DYNAP variants
Likely benign 3
- c.-28A>T Single submitter
- p.Val12Ile Single submitter
- p.Val55Met Single submitter ⚠
Uncertain significance 30
- c.13A>C Single submitter ⚠
- c.14T>C Single submitter
- c.20G>A Single submitter ⚠
- c.28C>A Single submitter ⚠
- c.-29G>C Single submitter ⚠
- p.Ala158Asp Single submitter ⚠
- p.Ala169Thr Single submitter ⚠
- p.Ala29Pro Single submitter ⚠
- p.Arg80His Single submitter ⚠
- p.Asp2Glu Single submitter ⚠
- p.Cys108Ser Single submitter ⚠
- p.Cys65Phe Single submitter ⚠
- p.Glu160Gln Single submitter ⚠
- p.Glu16Asp Single submitter ⚠
- p.Gly52Ala Single submitter ⚠
- p.Gly6Arg Single submitter ⚠
- p.Gly6Glu Single submitter ⚠
- p.Ile107Leu Single submitter ⚠
- p.Ile21Val Single submitter ⚠
- p.Leu60Phe Single submitter ⚠
- p.Leu93Phe Single submitter ⚠
- p.Leu94Val Single submitter ⚠
- p.Pro19Leu Single submitter ⚠
- p.Ser115Leu Single submitter ⚠
- p.Thr100Arg Single submitter ⚠
- p.Thr149Ala Single submitter ⚠
- p.Thr159Ala Single submitter ⚠
- p.Thr162Ile Single submitter ⚠
- p.Thr171Ala Single submitter ⚠
- p.Trp83Arg Single submitter ⚠