DYNLT3 — 11 ClinVar variants
All ClinVar germline DYNLT3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 9 flagged for review →
1 Benign · 10 Uncertain significance
Full DYNLT3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 9
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DYNLT3 p.Ala75Thr Uncertain significance Single submitter
- DYNLT3 p.Arg6Gly Uncertain significance Single submitter
- DYNLT3 p.Gln42Glu Uncertain significance Single submitter
- DYNLT3 p.His7Arg Uncertain significance Single submitter
- DYNLT3 p.Leu116Ile Uncertain significance Single submitter
- DYNLT3 p.Thr88Ile Uncertain significance Single submitter
- DYNLT3 p.Thr93Ser Uncertain significance Single submitter
- DYNLT3 p.Val11Leu Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All DYNLT3 variants
Benign 1
- p.Ala61= Multiple submitters
Uncertain significance 10
- p.Ala45Val Single submitter ⚠
- p.Ala75Thr Single submitter ⚠
- p.Arg101Trp Single submitter
- p.Arg6Gly Single submitter ⚠
- p.Gln42Glu Single submitter ⚠
- p.His7Arg Single submitter ⚠
- p.Leu116Ile Single submitter ⚠
- p.Thr88Ile Single submitter ⚠
- p.Thr93Ser Single submitter ⚠
- p.Val11Leu Single submitter ⚠