E2F4 — 54 ClinVar variants
All ClinVar germline E2F4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
1 Benign · 2 Likely benign · 51 Uncertain significance
Full E2F4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- E2F4 p.Ala138Val Uncertain significance Single submitter
- E2F4 p.Ala150Thr Uncertain significance Single submitter
- E2F4 p.Ala239Gly Uncertain significance Single submitter
- E2F4 p.Ala239Pro Uncertain significance Single submitter
- E2F4 p.Ala340Ser Uncertain significance Single submitter
- E2F4 p.Ala4Pro Uncertain significance Single submitter
- E2F4 p.Arg241Cys Uncertain significance Single submitter
- E2F4 p.Arg241His Uncertain significance Single submitter
- E2F4 p.Arg360Gly Uncertain significance Single submitter
- E2F4 p.Asn134Ser Uncertain significance Single submitter
- E2F4 p.Asn63Ser Uncertain significance Single submitter
- E2F4 p.Glu213Ala Uncertain significance Single submitter
- E2F4 p.Glu398Asp Uncertain significance Single submitter
- E2F4 p.Gly172Val Uncertain significance Single submitter
- E2F4 p.Gly272Asp Uncertain significance Single submitter
- E2F4 p.Gly272Ser Uncertain significance Single submitter
- E2F4 p.Gly328Arg Uncertain significance Single submitter
- E2F4 p.Ile145Thr Uncertain significance Single submitter
- E2F4 p.Ile355Met Uncertain significance Single submitter
- E2F4 p.Ile98Val Uncertain significance Single submitter
- E2F4 p.Lys350Arg Uncertain significance Single submitter
- E2F4 p.Lys74Asn Uncertain significance Single submitter
- E2F4 p.Lys82Gln Uncertain significance Single submitter
- E2F4 p.Pro210Gln Uncertain significance Single submitter
- E2F4 p.Pro212Ser Uncertain significance Single submitter
- E2F4 p.Pro337Ala Uncertain significance Single submitter
- E2F4 p.Pro342Thr Uncertain significance Single submitter
- E2F4 p.Ser124Asn Uncertain significance Single submitter
- E2F4 p.Ser16Cys Uncertain significance Single submitter
- E2F4 p.Ser201Asn Uncertain significance Single submitter
- E2F4 p.Ser218Gly Uncertain significance Single submitter
- E2F4 p.Ser75Thr Uncertain significance Single submitter
- E2F4 p.Val186Ala Uncertain significance Single submitter
- E2F4 p.Val30Leu Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- E2F4 p.Ala2Gly Uncertain significance Single submitter
- E2F4 p.Arg126Gln Uncertain significance Single submitter
- E2F4 p.Asp397Asn Uncertain significance Single submitter
- E2F4 p.Asp95Ala Uncertain significance Single submitter
- E2F4 p.Glu106Lys Uncertain significance Single submitter
- E2F4 p.Glu267Lys Uncertain significance Single submitter
- E2F4 p.Gly5Val Uncertain significance Single submitter
- E2F4 p.Leu173Phe Uncertain significance Single submitter
- E2F4 p.Leu289Arg Uncertain significance Single submitter
- E2F4 p.Pro15Arg Uncertain significance Single submitter
- E2F4 p.Pro15Leu Uncertain significance Single submitter
- E2F4 p.Pro211Leu Uncertain significance Single submitter
- E2F4 p.Ser16Gly Uncertain significance Single submitter
- E2F4 p.Ser301Cys Uncertain significance Single submitter
- E2F4 p.Ser317Gly Uncertain significance Single submitter
- E2F4 p.Ser319Asn Uncertain significance Single submitter
- E2F4 p.Val209Glu Uncertain significance Single submitter
All E2F4 variants
Benign 1
- p.Ser318_Ser319del Single submitter
Likely benign 2
- p.Asn243Ser Single submitter
- p.Asn322Ser Single submitter
Uncertain significance 51
- p.Ala138Val Single submitter ⚠
- p.Ala150Thr Single submitter ⚠
- p.Ala239Gly Single submitter ⚠
- p.Ala239Pro Single submitter ⚠
- p.Ala2Gly Single submitter ⚠
- p.Ala340Ser Single submitter ⚠
- p.Ala4Pro Single submitter ⚠
- p.Arg126Gln Single submitter ⚠
- p.Arg241Cys Single submitter ⚠
- p.Arg241His Single submitter ⚠
- p.Arg360Gly Single submitter ⚠
- p.Asn134Ser Single submitter ⚠
- p.Asn63Ser Single submitter ⚠
- p.Asp397Asn Single submitter ⚠
- p.Asp95Ala Single submitter ⚠
- p.Glu106Lys Single submitter ⚠
- p.Glu213Ala Single submitter ⚠
- p.Glu267Lys Single submitter ⚠
- p.Glu398Asp Single submitter ⚠
- p.Gly172Val Single submitter ⚠
- p.Gly272Asp Single submitter ⚠
- p.Gly272Ser Single submitter ⚠
- p.Gly328Arg Single submitter ⚠
- p.Gly5Val Single submitter ⚠
- p.Ile145Thr Single submitter ⚠
- p.Ile355Met Single submitter ⚠
- p.Ile98Val Single submitter ⚠
- p.Leu173Phe Single submitter ⚠
- p.Leu289Arg Single submitter ⚠
- p.Lys350Arg Single submitter ⚠
- p.Lys74Asn Single submitter ⚠
- p.Lys82Gln Single submitter ⚠
- p.Pro15Arg Single submitter ⚠
- p.Pro15Leu Single submitter ⚠
- p.Pro210Gln Single submitter ⚠
- p.Pro211Leu Single submitter ⚠
- p.Pro212Ser Single submitter ⚠
- p.Pro337Ala Single submitter ⚠
- p.Pro342Thr Single submitter ⚠
- p.Ser124Asn Single submitter ⚠
- p.Ser16Cys Single submitter ⚠
- p.Ser16Gly Single submitter ⚠
- p.Ser201Asn Single submitter ⚠
- p.Ser218Gly Single submitter ⚠
- p.Ser301Cys Single submitter ⚠
- p.Ser317Gly Single submitter ⚠
- p.Ser319Asn Single submitter ⚠
- p.Ser75Thr Single submitter ⚠
- p.Val186Ala Single submitter ⚠
- p.Val209Glu Single submitter ⚠
- p.Val30Leu Single submitter ⚠