EEIG2 — 34 ClinVar variants
All ClinVar germline EEIG2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
34 Uncertain significance
Full EEIG2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EEIG2 p.Ala100Thr Uncertain significance Single submitter
- EEIG2 p.Arg360His Uncertain significance Single submitter
- EEIG2 p.Asn25Ser Uncertain significance Single submitter
- EEIG2 p.Asp287Val Uncertain significance Single submitter
- EEIG2 p.Glu197Lys Uncertain significance Single submitter
- EEIG2 p.Gly199Val Uncertain significance Single submitter
- EEIG2 p.Ile159Val Uncertain significance Single submitter
- EEIG2 p.Ile161Val Uncertain significance Single submitter
- EEIG2 p.Ile257Thr Uncertain significance Single submitter
- EEIG2 p.Ile261Val Uncertain significance Single submitter
- EEIG2 p.Leu134Phe Uncertain significance Single submitter
- EEIG2 p.Leu279Arg Uncertain significance Single submitter
- EEIG2 p.Leu318Val Uncertain significance Single submitter
- EEIG2 p.Lys271Glu Uncertain significance Single submitter
- EEIG2 p.Phe107Leu Uncertain significance Single submitter
- EEIG2 p.Phe13Val Uncertain significance Single submitter
- EEIG2 p.Pro283Leu Uncertain significance Single submitter
- EEIG2 p.Ser165Pro Uncertain significance Single submitter
- EEIG2 p.Ser321Asn Uncertain significance Single submitter
- EEIG2 p.Ser341Gly Uncertain significance Single submitter
- EEIG2 p.Ser39Asn Uncertain significance Single submitter
- EEIG2 p.Thr114Ile Uncertain significance Single submitter
- EEIG2 p.Thr177Ile Uncertain significance Single submitter
- EEIG2 p.Thr268Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- EEIG2 p.Asp123Asn Uncertain significance Single submitter
- EEIG2 p.Asp12Asn Uncertain significance Single submitter
- EEIG2 p.Asp255Gly Uncertain significance Single submitter
- EEIG2 p.Asp319His Uncertain significance Single submitter
- EEIG2 p.Leu35Met Uncertain significance Single submitter
- EEIG2 p.Met2Lys Uncertain significance Single submitter
- EEIG2 p.Ser207Pro Uncertain significance Single submitter
- EEIG2 p.Ser321Ile Uncertain significance Single submitter
- EEIG2 p.Ser69Gly Uncertain significance Single submitter
- EEIG2 p.Thr245Ile Uncertain significance Single submitter
All EEIG2 variants
Uncertain significance 34
- p.Ala100Thr Single submitter ⚠
- p.Arg360His Single submitter ⚠
- p.Asn25Ser Single submitter ⚠
- p.Asp123Asn Single submitter ⚠
- p.Asp12Asn Single submitter ⚠
- p.Asp255Gly Single submitter ⚠
- p.Asp287Val Single submitter ⚠
- p.Asp319His Single submitter ⚠
- p.Glu197Lys Single submitter ⚠
- p.Gly199Val Single submitter ⚠
- p.Ile159Val Single submitter ⚠
- p.Ile161Val Single submitter ⚠
- p.Ile257Thr Single submitter ⚠
- p.Ile261Val Single submitter ⚠
- p.Leu134Phe Single submitter ⚠
- p.Leu279Arg Single submitter ⚠
- p.Leu318Val Single submitter ⚠
- p.Leu35Met Single submitter ⚠
- p.Lys271Glu Single submitter ⚠
- p.Met2Lys Single submitter ⚠
- p.Phe107Leu Single submitter ⚠
- p.Phe13Val Single submitter ⚠
- p.Pro283Leu Single submitter ⚠
- p.Ser165Pro Single submitter ⚠
- p.Ser207Pro Single submitter ⚠
- p.Ser321Asn Single submitter ⚠
- p.Ser321Ile Single submitter ⚠
- p.Ser341Gly Single submitter ⚠
- p.Ser39Asn Single submitter ⚠
- p.Ser69Gly Single submitter ⚠
- p.Thr114Ile Single submitter ⚠
- p.Thr177Ile Single submitter ⚠
- p.Thr245Ile Single submitter ⚠
- p.Thr268Ile Single submitter ⚠