Sugi Variant

Sugi Variant/EGF

EGF — 638 ClinVar variants

All ClinVar germline EGF variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 261 flagged for review →

1 Pathogenic · 2 Likely pathogenic · 22 Conflicting · 116 Benign · 17 Benign/Likely benign · 153 Likely benign · 327 Uncertain significance

Full EGF gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 261

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 3

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 150

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 107

The independent predictors disagree with each other — read with care.

All EGF variants

Pathogenic 1

Likely pathogenic 2

Conflicting classifications of pathogenicity 22

Benign 116

Benign/Likely benign 17

Likely benign 153

Uncertain significance 327

Showing the top 300 by review status; the full set is in the sitemap.