EIF1B — 6 ClinVar variants
All ClinVar germline EIF1B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 6 flagged for review →
6 Uncertain significance
Full EIF1B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 6
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 2
The independent predictors disagree with each other — read with care.
All EIF1B variants
Uncertain significance 6
- p.Ala14Gly Single submitter ⚠
- p.Arg41Lys Single submitter ⚠
- p.Gln86Arg Single submitter ⚠
- p.Phe13Leu Single submitter ⚠
- p.Val73Leu Single submitter ⚠
- p.Val82Ile Single submitter ⚠