EIF3CL — 12 ClinVar variants
All ClinVar germline EIF3CL variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 12 flagged for review →
12 Uncertain significance
Full EIF3CL gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 12
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EIF3CL p.Arg348Ser Uncertain significance Single submitter
- EIF3CL p.Asn297Ser Uncertain significance Single submitter
- EIF3CL p.Ile331Thr Uncertain significance Single submitter
- EIF3CL p.Lys267Arg Uncertain significance Single submitter
- EIF3CL p.Lys321Arg Uncertain significance Single submitter
- EIF3CL p.Pro310Leu Uncertain significance Single submitter
- EIF3CL p.Val329Ala Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All EIF3CL variants
Uncertain significance 12
- p.Arg304Gly Single submitter ⚠
- p.Arg306Leu Single submitter ⚠
- p.Arg306Trp Single submitter ⚠
- p.Arg348Ser Single submitter ⚠
- p.Asn297Ser Single submitter ⚠
- p.Gly308Ala Single submitter ⚠
- p.Ile331Ser Single submitter ⚠
- p.Ile331Thr Single submitter ⚠
- p.Lys267Arg Single submitter ⚠
- p.Lys321Arg Single submitter ⚠
- p.Pro310Leu Single submitter ⚠
- p.Val329Ala Single submitter ⚠