EIF4E3 — 36 ClinVar variants
All ClinVar germline EIF4E3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
36 Uncertain significance
Full EIF4E3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EIF4E3 p.Ala155Thr Uncertain significance Single submitter
- EIF4E3 p.Ala156Thr Uncertain significance Single submitter
- EIF4E3 p.Ala22Thr Uncertain significance Single submitter
- EIF4E3 p.Ala25Val Uncertain significance Single submitter
- EIF4E3 p.Ala6Val Uncertain significance Single submitter
- EIF4E3 p.Ala70Thr Uncertain significance Single submitter
- EIF4E3 p.Arg14Leu Uncertain significance Single submitter
- EIF4E3 p.Arg14Trp Uncertain significance Single submitter
- EIF4E3 p.Arg169Trp Uncertain significance Single submitter
- EIF4E3 p.Arg221Cys Uncertain significance Single submitter
- EIF4E3 p.Gln36Pro Uncertain significance Single submitter
- EIF4E3 p.Glu118Asp Uncertain significance Single submitter
- EIF4E3 p.Glu141Gln Uncertain significance Single submitter
- EIF4E3 p.Gly148Arg Uncertain significance Single submitter
- EIF4E3 p.Gly18Ala Uncertain significance Single submitter
- EIF4E3 p.Ile201Val Uncertain significance Single submitter
- EIF4E3 p.Leu40Val Uncertain significance Single submitter
- EIF4E3 p.Pro10Arg Uncertain significance Single submitter
- EIF4E3 p.Pro28Leu Uncertain significance Single submitter
- EIF4E3 p.Pro30Gln Uncertain significance Single submitter
- EIF4E3 p.Pro42Ser Uncertain significance Single submitter
- EIF4E3 p.Pro4Leu Uncertain significance Single submitter
- EIF4E3 p.Ser136Thr Uncertain significance Single submitter
- EIF4E3 p.Thr96Ser Uncertain significance Single submitter
- EIF4E3 p.Trp139Ser Uncertain significance Single submitter
- EIF4E3 p.Val138Ile Uncertain significance Single submitter
- EIF4E3 p.Val175Ile Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- EIF4E3 p.His214Asp Uncertain significance Single submitter
- EIF4E3 p.Pro10His Uncertain significance Single submitter
- EIF4E3 p.Pro4Thr Uncertain significance Single submitter
- EIF4E3 p.Pro5Ser Uncertain significance Single submitter
- EIF4E3 p.Pro9Thr Uncertain significance Single submitter
- EIF4E3 p.Ser165Asn Uncertain significance Single submitter
- EIF4E3 p.Ser167Asn Uncertain significance Single submitter
- EIF4E3 p.Ser167Gly Uncertain significance Single submitter
- EIF4E3 p.Ser51Trp Uncertain significance Single submitter
All EIF4E3 variants
Uncertain significance 36
- p.Ala155Thr Single submitter ⚠
- p.Ala156Thr Single submitter ⚠
- p.Ala22Thr Single submitter ⚠
- p.Ala25Val Single submitter ⚠
- p.Ala6Val Single submitter ⚠
- p.Ala70Thr Single submitter ⚠
- p.Arg14Leu Single submitter ⚠
- p.Arg14Trp Single submitter ⚠
- p.Arg169Trp Single submitter ⚠
- p.Arg221Cys Single submitter ⚠
- p.Gln36Pro Single submitter ⚠
- p.Glu118Asp Single submitter ⚠
- p.Glu141Gln Single submitter ⚠
- p.Gly148Arg Single submitter ⚠
- p.Gly18Ala Single submitter ⚠
- p.His214Asp Single submitter ⚠
- p.Ile201Val Single submitter ⚠
- p.Leu40Val Single submitter ⚠
- p.Pro10Arg Single submitter ⚠
- p.Pro10His Single submitter ⚠
- p.Pro28Leu Single submitter ⚠
- p.Pro30Gln Single submitter ⚠
- p.Pro42Ser Single submitter ⚠
- p.Pro4Leu Single submitter ⚠
- p.Pro4Thr Single submitter ⚠
- p.Pro5Ser Single submitter ⚠
- p.Pro9Thr Single submitter ⚠
- p.Ser136Thr Single submitter ⚠
- p.Ser165Asn Single submitter ⚠
- p.Ser167Asn Single submitter ⚠
- p.Ser167Gly Single submitter ⚠
- p.Ser51Trp Single submitter ⚠
- p.Thr96Ser Single submitter ⚠
- p.Trp139Ser Single submitter ⚠
- p.Val138Ile Single submitter ⚠
- p.Val175Ile Single submitter ⚠