EIF4EBP2 — 20 ClinVar variants
All ClinVar germline EIF4EBP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 19 flagged for review →
1 Benign · 1 Likely benign · 18 Uncertain significance
Full EIF4EBP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 19
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EIF4EBP2 p.Ala23Thr Uncertain significance Single submitter
- EIF4EBP2 p.Asn103Ser Uncertain significance Single submitter
- EIF4EBP2 p.Asp105His Uncertain significance Single submitter
- EIF4EBP2 p.His104Gln Uncertain significance Single submitter
- EIF4EBP2 p.His32Pro Uncertain significance Single submitter
- EIF4EBP2 p.Ile52Val Uncertain significance Single submitter
- EIF4EBP2 p.Met67Ile Uncertain significance Single submitter
- EIF4EBP2 p.Pro71Leu Uncertain significance Single submitter
- EIF4EBP2 p.Thr45Asn Uncertain significance Single submitter
- EIF4EBP2 p.Thr70Asn Uncertain significance Single submitter
- EIF4EBP2 p.Tyr54Phe Uncertain significance Single submitter
- EIF4EBP2 p.Val95Gly Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- EIF4EBP2 p.Gly6Asp Likely benign Multiple submitters
- EIF4EBP2 p.Asn102Lys Uncertain significance Single submitter
- EIF4EBP2 p.His108Tyr Uncertain significance Single submitter
- EIF4EBP2 p.His74Leu Uncertain significance Single submitter
- EIF4EBP2 p.Leu98Trp Uncertain significance Single submitter
- EIF4EBP2 p.Ser25Gly Uncertain significance Single submitter
- EIF4EBP2 p.Ser2Phe Uncertain significance Single submitter
All EIF4EBP2 variants
Benign 1
- p.Ser7= Single submitter
Uncertain significance 18
- p.Ala23Thr Single submitter ⚠
- p.Asn102Lys Single submitter ⚠
- p.Asn103Ser Single submitter ⚠
- p.Asp105His Single submitter ⚠
- p.His104Gln Single submitter ⚠
- p.His108Tyr Single submitter ⚠
- p.His32Pro Single submitter ⚠
- p.His74Leu Single submitter ⚠
- p.Ile52Val Single submitter ⚠
- p.Leu98Trp Single submitter ⚠
- p.Met67Ile Single submitter ⚠
- p.Pro71Leu Single submitter ⚠
- p.Ser25Gly Single submitter ⚠
- p.Ser2Phe Single submitter ⚠
- p.Thr45Asn Single submitter ⚠
- p.Thr70Asn Single submitter ⚠
- p.Tyr54Phe Single submitter ⚠
- p.Val95Gly Single submitter ⚠