EIF4H — 15 ClinVar variants
All ClinVar germline EIF4H variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 14 flagged for review →
2 Likely benign · 13 Uncertain significance
Full EIF4H gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 14
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EIF4H p.Ala11Ser Uncertain significance Single submitter
- EIF4H p.Ala11Thr Uncertain significance Single submitter
- EIF4H p.Arg109Trp Uncertain significance Single submitter
- EIF4H p.Asn155Ser Uncertain significance Single submitter
- EIF4H p.Ser182Asn Uncertain significance Single submitter
- EIF4H p.Thr6Ala Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- EIF4H p.Arg151Gln Uncertain significance Single submitter
- EIF4H p.Asp9Asn Uncertain significance Single submitter
- EIF4H p.Gln212His Uncertain significance Single submitter
- EIF4H p.Pro179Ala Uncertain significance Single submitter
- EIF4H p.Pro179Ser Uncertain significance Single submitter
- EIF4H p.Thr220Met Uncertain significance Single submitter
- EIF4H p.Val46Ile Uncertain significance Single submitter
- EIF4H p.Val70Ile Likely benign Single submitter
All EIF4H variants
Likely benign 2
- p.Gln244= Single submitter
- p.Val70Ile Single submitter ⚠
Uncertain significance 13
- p.Ala11Ser Single submitter ⚠
- p.Ala11Thr Single submitter ⚠
- p.Arg109Trp Single submitter ⚠
- p.Arg151Gln Single submitter ⚠
- p.Asn155Ser Single submitter ⚠
- p.Asp9Asn Single submitter ⚠
- p.Gln212His Single submitter ⚠
- p.Pro179Ala Single submitter ⚠
- p.Pro179Ser Single submitter ⚠
- p.Ser182Asn Single submitter ⚠
- p.Thr220Met Single submitter ⚠
- p.Thr6Ala Single submitter ⚠
- p.Val46Ile Single submitter ⚠