ELF1 — 83 ClinVar variants
All ClinVar germline ELF1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 80 flagged for review →
2 Benign · 1 Likely benign · 80 Uncertain significance
Full ELF1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 80
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 58
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ELF1 p.Ala29Thr Uncertain significance Single submitter
- ELF1 p.Ala353Ser Uncertain significance Single submitter
- ELF1 p.Ala459Val Uncertain significance Single submitter
- ELF1 p.Arg323Thr Uncertain significance Single submitter
- ELF1 p.Arg328Gln Uncertain significance Single submitter
- ELF1 p.Arg330Lys Uncertain significance Single submitter
- ELF1 p.Arg369Lys Uncertain significance Single submitter
- ELF1 p.Asn107Ser Uncertain significance Single submitter
- ELF1 p.Asn511Ser Uncertain significance Single submitter
- ELF1 p.Asn617Thr Uncertain significance Single submitter
- ELF1 p.Asp162Asn Uncertain significance Single submitter
- ELF1 p.Asp21Asn Uncertain significance Single submitter
- ELF1 p.Asp456Ala Uncertain significance Single submitter
- ELF1 p.Asp59Gly Uncertain significance Single submitter
- ELF1 p.Asp67Gly Uncertain significance Single submitter
- ELF1 p.Asp9Asn Uncertain significance Single submitter
- ELF1 p.Gln171Glu Uncertain significance Single submitter
- ELF1 p.Gln487His Uncertain significance Single submitter
- ELF1 p.Gln543Arg Uncertain significance Single submitter
- ELF1 p.Gln590Leu Uncertain significance Single submitter
- ELF1 p.Glu586Gly Uncertain significance Single submitter
- ELF1 p.Glu612Ala Uncertain significance Single submitter
- ELF1 p.Glu612Asp Uncertain significance Single submitter
- ELF1 p.Gly26Cys Uncertain significance Single submitter
- ELF1 p.Gly550Arg Uncertain significance Single submitter
- ELF1 p.Gly92Arg Uncertain significance Single submitter
- ELF1 p.His90Arg Uncertain significance Single submitter
- ELF1 p.Ile308Val Uncertain significance Single submitter
- ELF1 p.Ile30Val Uncertain significance Single submitter
- ELF1 p.Ile497Val Uncertain significance Single submitter
- ELF1 p.Leu296Val Uncertain significance Single submitter
- ELF1 p.Leu613Gln Uncertain significance Single submitter
- ELF1 p.Leu66Val Uncertain significance Single submitter
- ELF1 p.Lys465Asn Uncertain significance Single submitter
- ELF1 p.Lys465Thr Uncertain significance Single submitter
- ELF1 p.Met114Val Uncertain significance Single submitter
- ELF1 p.Met608Thr Uncertain significance Single submitter
- ELF1 p.Pro164Leu Uncertain significance Single submitter
- ELF1 p.Pro169Ser Uncertain significance Single submitter
- ELF1 p.Pro313Ser Uncertain significance Single submitter
- ELF1 p.Pro433Ser Uncertain significance Single submitter
- ELF1 p.Pro494Ser Uncertain significance Single submitter
- ELF1 p.Pro533Ser Uncertain significance Single submitter
- ELF1 p.Pro589Leu Uncertain significance Single submitter
- ELF1 p.Ser598Gly Uncertain significance Single submitter
- ELF1 p.Thr478Ala Uncertain significance Single submitter
- ELF1 p.Thr509Asn Uncertain significance Single submitter
- ELF1 p.Thr603Ile Uncertain significance Single submitter
- ELF1 p.Tyr209Cys Uncertain significance Single submitter
- ELF1 p.Val18Ile Uncertain significance Single submitter
- ELF1 p.Val361Ile Uncertain significance Single submitter
- ELF1 p.Val388Ile Uncertain significance Single submitter
- ELF1 p.Val427Ile Uncertain significance Single submitter
- ELF1 p.Val451Leu Uncertain significance Single submitter
- ELF1 p.Val4Ile Uncertain significance Single submitter
- ELF1 p.Val520Ile Uncertain significance Single submitter
- ELF1 p.Val552Ala Uncertain significance Single submitter
- ELF1 p.Val68Ile Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- ELF1 p.Arg384Trp Uncertain significance Single submitter
- ELF1 p.Asp408Tyr Uncertain significance Single submitter
- ELF1 p.Gln375Leu Uncertain significance Single submitter
- ELF1 p.Gln426Glu Uncertain significance Single submitter
- ELF1 p.Gly550Asp Uncertain significance Single submitter
- ELF1 p.Ile297Met Uncertain significance Single submitter
- ELF1 p.Ile471Phe Uncertain significance Single submitter
- ELF1 p.Leu106Val Uncertain significance Single submitter
- ELF1 p.Leu411Phe Uncertain significance Single submitter
- ELF1 p.Lys294Glu Uncertain significance Single submitter
- ELF1 p.Pro347Leu Uncertain significance Single submitter
- ELF1 p.Ser168Leu Uncertain significance Single submitter
- ELF1 p.Ser195Cys Uncertain significance Single submitter
- ELF1 p.Ser314Leu Uncertain significance Single submitter
- ELF1 p.Ser493Cys Uncertain significance Single submitter
- ELF1 p.Thr551Ile Uncertain significance Single submitter
- ELF1 p.Thr95Ile Uncertain significance Single submitter
- ELF1 p.Tyr48His Uncertain significance Single submitter
- ELF1 p.Val359Gly Uncertain significance Single submitter
- ELF1 p.Val371Met Uncertain significance Single submitter
- ELF1 p.Val386Leu Uncertain significance Single submitter
- ELF1 p.Val535Met Uncertain significance Single submitter
All ELF1 variants
Likely benign 1
- p.Met608Val Single submitter
Uncertain significance 80
- p.Ala29Thr Single submitter ⚠
- p.Ala353Ser Single submitter ⚠
- p.Ala459Val Single submitter ⚠
- p.Arg323Thr Single submitter ⚠
- p.Arg328Gln Single submitter ⚠
- p.Arg330Lys Single submitter ⚠
- p.Arg369Lys Single submitter ⚠
- p.Arg384Trp Single submitter ⚠
- p.Asn107Ser Single submitter ⚠
- p.Asn511Ser Single submitter ⚠
- p.Asn617Thr Single submitter ⚠
- p.Asp162Asn Single submitter ⚠
- p.Asp21Asn Single submitter ⚠
- p.Asp408Tyr Single submitter ⚠
- p.Asp456Ala Single submitter ⚠
- p.Asp59Gly Single submitter ⚠
- p.Asp67Gly Single submitter ⚠
- p.Asp9Asn Single submitter ⚠
- p.Gln171Glu Single submitter ⚠
- p.Gln375Leu Single submitter ⚠
- p.Gln426Glu Single submitter ⚠
- p.Gln487His Single submitter ⚠
- p.Gln543Arg Single submitter ⚠
- p.Gln590Leu Single submitter ⚠
- p.Glu586Gly Single submitter ⚠
- p.Glu612Ala Single submitter ⚠
- p.Glu612Asp Single submitter ⚠
- p.Gly26Cys Single submitter ⚠
- p.Gly550Arg Single submitter ⚠
- p.Gly550Asp Single submitter ⚠
- p.Gly92Arg Single submitter ⚠
- p.His90Arg Single submitter ⚠
- p.Ile297Met Single submitter ⚠
- p.Ile308Val Single submitter ⚠
- p.Ile30Val Single submitter ⚠
- p.Ile471Phe Single submitter ⚠
- p.Ile497Val Single submitter ⚠
- p.Leu106Val Single submitter ⚠
- p.Leu296Val Single submitter ⚠
- p.Leu411Phe Single submitter ⚠
- p.Leu613Gln Single submitter ⚠
- p.Leu66Val Single submitter ⚠
- p.Lys294Glu Single submitter ⚠
- p.Lys465Asn Single submitter ⚠
- p.Lys465Thr Single submitter ⚠
- p.Met114Val Single submitter ⚠
- p.Met608Thr Single submitter ⚠
- p.Pro164Leu Single submitter ⚠
- p.Pro169Ser Single submitter ⚠
- p.Pro313Ser Single submitter ⚠
- p.Pro347Leu Single submitter ⚠
- p.Pro433Ser Single submitter ⚠
- p.Pro494Ser Single submitter ⚠
- p.Pro533Ser Single submitter ⚠
- p.Pro589Leu Single submitter ⚠
- p.Ser168Leu Single submitter ⚠
- p.Ser195Cys Single submitter ⚠
- p.Ser314Leu Single submitter ⚠
- p.Ser493Cys Single submitter ⚠
- p.Ser598Gly Single submitter ⚠
- p.Thr478Ala Single submitter ⚠
- p.Thr509Asn Single submitter ⚠
- p.Thr551Ile Single submitter ⚠
- p.Thr603Ile Single submitter ⚠
- p.Thr95Ile Single submitter ⚠
- p.Tyr209Cys Single submitter ⚠
- p.Tyr48His Single submitter ⚠
- p.Val18Ile Single submitter ⚠
- p.Val359Gly Single submitter ⚠
- p.Val361Ile Single submitter ⚠
- p.Val371Met Single submitter ⚠
- p.Val386Leu Single submitter ⚠
- p.Val388Ile Single submitter ⚠
- p.Val427Ile Single submitter ⚠
- p.Val451Leu Single submitter ⚠
- p.Val4Ile Single submitter ⚠
- p.Val520Ile Single submitter ⚠
- p.Val535Met Single submitter ⚠
- p.Val552Ala Single submitter ⚠
- p.Val68Ile Single submitter ⚠