ENO2 — 43 ClinVar variants
All ClinVar germline ENO2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
1 Benign · 2 Likely benign · 40 Uncertain significance
Full ENO2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ENO2 p.Ala27Asp Uncertain significance Single submitter
- ENO2 p.Ala331Thr Uncertain significance Single submitter
- ENO2 p.Arg327His Uncertain significance Single submitter
- ENO2 p.Arg32Gln Uncertain significance Single submitter
- ENO2 p.Arg372His Uncertain significance Single submitter
- ENO2 p.Arg400His Uncertain significance Single submitter
- ENO2 p.Arg403His Uncertain significance Single submitter
- ENO2 p.Asn109Ser Uncertain significance Single submitter
- ENO2 p.Asn154Ser Uncertain significance Single submitter
- ENO2 p.Asn161Lys Uncertain significance Single submitter
- ENO2 p.Asn310Ser Uncertain significance Single submitter
- ENO2 p.Asn92Ser Uncertain significance Single submitter
- ENO2 p.Gly201Asp Uncertain significance Single submitter
- ENO2 p.Gly201Ser Uncertain significance Single submitter
- ENO2 p.His190Arg Uncertain significance Single submitter
- ENO2 p.Ile393Val Uncertain significance Single submitter
- ENO2 p.Met182Thr Uncertain significance Single submitter
- ENO2 p.Phe178Leu Uncertain significance Single submitter
- ENO2 p.Ser177Asn Uncertain significance Single submitter
- ENO2 p.Ser373Leu Uncertain significance Single submitter
- ENO2 p.Trp7Arg Uncertain significance Single submitter
- ENO2 p.Val152Leu Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- ENO2 p.Arg126Trp Uncertain significance Single submitter
- ENO2 p.Arg179Gln Uncertain significance Single submitter
- ENO2 p.Arg183Gln Uncertain significance Single submitter
- ENO2 p.Arg269Gln Uncertain significance Single submitter
- ENO2 p.Arg269Leu Uncertain significance Single submitter
- ENO2 p.Arg56Cys Uncertain significance Single submitter
- ENO2 p.Arg56His Uncertain significance Single submitter
- ENO2 p.Asn216Ser Uncertain significance Single submitter
- ENO2 p.Asp254Gly Uncertain significance Single submitter
- ENO2 p.Gln409Glu Uncertain significance Single submitter
- ENO2 p.Leu49Met Uncertain significance Single submitter
- ENO2 p.Lys239Asn Uncertain significance Single submitter
- ENO2 p.Ser305Phe Uncertain significance Single submitter
- ENO2 p.Tyr44Cys Uncertain significance Single submitter
- ENO2 p.Val118Leu Uncertain significance Single submitter
- ENO2 p.Val118Met Uncertain significance Single submitter
- ENO2 p.Val85Met Uncertain significance Single submitter
All ENO2 variants
Benign 1
- c.311-9A>C Single submitter
Likely benign 2
Uncertain significance 40
- c.1235+2_1235+5dup Single submitter hereditary breast ovarian cancer syndrome
- p.Ala27Asp Single submitter ⚠
- p.Ala331Thr Single submitter ⚠
- p.Arg126Trp Single submitter ⚠
- p.Arg179Gln Single submitter ⚠
- p.Arg183Gln Single submitter ⚠
- p.Arg269Gln Single submitter ⚠
- p.Arg269Leu Single submitter ⚠
- p.Arg327His Single submitter ⚠
- p.Arg32Gln Single submitter ⚠
- p.Arg372His Single submitter ⚠
- p.Arg400His Single submitter ⚠
- p.Arg403His Single submitter ⚠
- p.Arg56Cys Single submitter ⚠
- p.Arg56His Single submitter ⚠
- p.Asn109Ser Single submitter ⚠
- p.Asn154Ser Single submitter ⚠
- p.Asn161Lys Single submitter ⚠
- p.Asn216Ser Single submitter ⚠
- p.Asn310Ser Single submitter ⚠
- p.Asn92Ser Single submitter ⚠
- p.Asp254Gly Single submitter ⚠
- p.Gln409Glu Single submitter ⚠
- p.Gly201Asp Single submitter ⚠
- p.Gly201Ser Single submitter ⚠
- p.His190Arg Single submitter ⚠
- p.Ile393Val Single submitter ⚠
- p.Leu49Met Single submitter ⚠
- p.Lys239Asn Single submitter ⚠
- p.Met182Thr Single submitter ⚠
- p.Phe178Leu Single submitter ⚠
- p.Ser177Asn Single submitter ⚠
- p.Ser305Phe Single submitter ⚠
- p.Ser373Leu Single submitter ⚠
- p.Trp7Arg Single submitter ⚠
- p.Tyr44Cys Single submitter ⚠
- p.Val118Leu Single submitter ⚠
- p.Val118Met Single submitter ⚠
- p.Val152Leu Single submitter ⚠
- p.Val85Met Single submitter ⚠