ENPP4 — 66 ClinVar variants
All ClinVar germline ENPP4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
1 Likely benign · 65 Uncertain significance
Full ENPP4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ENPP4 p.Ala190Glu Uncertain significance Single submitter
- ENPP4 p.Ala190Thr Uncertain significance Single submitter
- ENPP4 p.Ala355Ser Uncertain significance Single submitter
- ENPP4 p.Ala409Val Uncertain significance Single submitter
- ENPP4 p.Ala90Ser Uncertain significance Single submitter
- ENPP4 p.Asn250Tyr Uncertain significance Single submitter
- ENPP4 p.Asn276Ser Uncertain significance Single submitter
- ENPP4 p.Asp107Gly Uncertain significance Single submitter
- ENPP4 p.Asp211Glu Uncertain significance Single submitter
- ENPP4 p.Asp319Glu Uncertain significance Single submitter
- ENPP4 p.Glu406Lys Uncertain significance Single submitter
- ENPP4 p.Gly196Arg Uncertain significance Single submitter
- ENPP4 p.Gly353Arg Uncertain significance Single submitter
- ENPP4 p.Gly413Ser Uncertain significance Single submitter
- ENPP4 p.Gly80Ser Uncertain significance Single submitter
- ENPP4 p.His101Leu Uncertain significance Single submitter
- ENPP4 p.His144Arg Uncertain significance Single submitter
- ENPP4 p.His346Gln Uncertain significance Single submitter
- ENPP4 p.His357Gln Uncertain significance Single submitter
- ENPP4 p.His61Arg Uncertain significance Single submitter
- ENPP4 p.Ile147Leu Uncertain significance Single submitter
- ENPP4 p.Ile365Val Uncertain significance Single submitter
- ENPP4 p.Ile412Ser Uncertain significance Single submitter
- ENPP4 p.Ile425Val Uncertain significance Single submitter
- ENPP4 p.Ile452Thr Uncertain significance Single submitter
- ENPP4 p.Lys194Arg Uncertain significance Single submitter
- ENPP4 p.Lys27Arg Uncertain significance Single submitter
- ENPP4 p.Pro267Leu Uncertain significance Single submitter
- ENPP4 p.Pro435Ser Uncertain significance Single submitter
- ENPP4 p.Ser105Thr Uncertain significance Single submitter
- ENPP4 p.Ser159Pro Uncertain significance Single submitter
- ENPP4 p.Ser23Thr Uncertain significance Single submitter
- ENPP4 p.Thr364Lys Uncertain significance Single submitter
- ENPP4 p.Trp136Arg Uncertain significance Single submitter
Predictors split 32
The independent predictors disagree with each other — read with care.
- ENPP4 p.Ala181Thr Uncertain significance Single submitter
- ENPP4 p.Ala355Gly Uncertain significance Single submitter
- ENPP4 p.Ala409Thr Uncertain significance Single submitter
- ENPP4 p.Arg129Thr Uncertain significance Single submitter
- ENPP4 p.Arg310Gln Uncertain significance Single submitter
- ENPP4 p.Arg436Cys Uncertain significance Single submitter
- ENPP4 p.Asp252His Uncertain significance Single submitter
- ENPP4 p.Glu45Gly Uncertain significance Single submitter
- ENPP4 p.Gly11Arg Uncertain significance Single submitter
- ENPP4 p.His290Gln Uncertain significance Single submitter
- ENPP4 p.Ile263Thr Uncertain significance Single submitter
- ENPP4 p.Ile311Met Uncertain significance Single submitter
- ENPP4 p.Ile410Phe Uncertain significance Single submitter
- ENPP4 p.Leu295Phe Uncertain significance Single submitter
- ENPP4 p.Lys100Asn Uncertain significance Single submitter
- ENPP4 p.Lys100Glu Uncertain significance Single submitter
- ENPP4 p.Lys274Gln Uncertain significance Single submitter
- ENPP4 p.Met152Arg Uncertain significance Single submitter
- ENPP4 p.Met93Leu Uncertain significance Single submitter
- ENPP4 p.Phe348Leu Uncertain significance Single submitter
- ENPP4 p.Pro25Thr Uncertain significance Single submitter
- ENPP4 p.Pro26Arg Uncertain significance Single submitter
- ENPP4 p.Ser105Cys Uncertain significance Single submitter
- ENPP4 p.Ser105Phe Likely benign Single submitter
- ENPP4 p.Ser439Ala Uncertain significance Single submitter
- ENPP4 p.Ser92Cys Uncertain significance Single submitter
- ENPP4 p.Thr146Ala Uncertain significance Single submitter
- ENPP4 p.Tyr150Phe Uncertain significance Single submitter
- ENPP4 p.Val280Phe Uncertain significance Single submitter
- ENPP4 p.Val417Met Uncertain significance Single submitter
- ENPP4 p.Val57Ile Uncertain significance Single submitter
- ENPP4 p.Val89Met Uncertain significance Single submitter
All ENPP4 variants
Likely benign 1
- p.Ser105Phe Single submitter ⚠
Uncertain significance 65
- p.Ala181Thr Single submitter ⚠
- p.Ala190Glu Single submitter ⚠
- p.Ala190Thr Single submitter ⚠
- p.Ala355Gly Single submitter ⚠
- p.Ala355Ser Single submitter ⚠
- p.Ala409Thr Single submitter ⚠
- p.Ala409Val Single submitter ⚠
- p.Ala90Ser Single submitter ⚠
- p.Arg129Thr Single submitter ⚠
- p.Arg310Gln Single submitter ⚠
- p.Arg436Cys Single submitter ⚠
- p.Asn250Tyr Single submitter ⚠
- p.Asn276Ser Single submitter ⚠
- p.Asp107Gly Single submitter ⚠
- p.Asp211Glu Single submitter ⚠
- p.Asp252His Single submitter ⚠
- p.Asp319Glu Single submitter ⚠
- p.Glu406Lys Single submitter ⚠
- p.Glu45Gly Single submitter ⚠
- p.Gly11Arg Single submitter ⚠
- p.Gly196Arg Single submitter ⚠
- p.Gly353Arg Single submitter ⚠
- p.Gly413Ser Single submitter ⚠
- p.Gly80Ser Single submitter ⚠
- p.His101Leu Single submitter ⚠
- p.His144Arg Single submitter ⚠
- p.His290Gln Single submitter ⚠
- p.His346Gln Single submitter ⚠
- p.His357Gln Single submitter ⚠
- p.His61Arg Single submitter ⚠
- p.Ile147Leu Single submitter ⚠
- p.Ile263Thr Single submitter ⚠
- p.Ile311Met Single submitter ⚠
- p.Ile365Val Single submitter ⚠
- p.Ile410Phe Single submitter ⚠
- p.Ile412Ser Single submitter ⚠
- p.Ile425Val Single submitter ⚠
- p.Ile452Thr Single submitter ⚠
- p.Leu295Phe Single submitter ⚠
- p.Lys100Asn Single submitter ⚠
- p.Lys100Glu Single submitter ⚠
- p.Lys194Arg Single submitter ⚠
- p.Lys274Gln Single submitter ⚠
- p.Lys27Arg Single submitter ⚠
- p.Met152Arg Single submitter ⚠
- p.Met93Leu Single submitter ⚠
- p.Phe348Leu Single submitter ⚠
- p.Pro25Thr Single submitter ⚠
- p.Pro267Leu Single submitter ⚠
- p.Pro26Arg Single submitter ⚠
- p.Pro435Ser Single submitter ⚠
- p.Ser105Cys Single submitter ⚠
- p.Ser105Thr Single submitter ⚠
- p.Ser159Pro Single submitter ⚠
- p.Ser23Thr Single submitter ⚠
- p.Ser439Ala Single submitter ⚠
- p.Ser92Cys Single submitter ⚠
- p.Thr146Ala Single submitter ⚠
- p.Thr364Lys Single submitter ⚠
- p.Trp136Arg Single submitter ⚠
- p.Tyr150Phe Single submitter ⚠
- p.Val280Phe Single submitter ⚠
- p.Val417Met Single submitter ⚠
- p.Val57Ile Single submitter ⚠
- p.Val89Met Single submitter ⚠