ENTR1 — 113 ClinVar variants
All ClinVar germline ENTR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 107 flagged for review →
4 Likely benign · 109 Uncertain significance
Full ENTR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 107
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 95
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ENTR1 p.Ala106Gly Uncertain significance Single submitter
- ENTR1 p.Ala106Pro Uncertain significance Single submitter
- ENTR1 p.Ala192Thr Uncertain significance Single submitter
- ENTR1 p.Ala231Val Uncertain significance Single submitter
- ENTR1 p.Ala250Ser Uncertain significance Single submitter
- ENTR1 p.Ala253Val Uncertain significance Single submitter
- ENTR1 p.Ala26Glu Uncertain significance Single submitter
- ENTR1 p.Ala273Val Uncertain significance Single submitter
- ENTR1 p.Ala357Val Uncertain significance Single submitter
- ENTR1 p.Ala375Val Uncertain significance Single submitter
- ENTR1 p.Arg238His Uncertain significance Single submitter
- ENTR1 p.Arg30Leu Uncertain significance Single submitter
- ENTR1 p.Arg370Gln Uncertain significance Single submitter
- ENTR1 p.Arg41His Uncertain significance Single submitter
- ENTR1 p.Arg424Lys Uncertain significance Single submitter
- ENTR1 p.Arg424Thr Uncertain significance Single submitter
- ENTR1 p.Arg55Trp Uncertain significance Single submitter
- ENTR1 p.Arg99Ile Uncertain significance Single submitter
- ENTR1 p.Asn361Ser Uncertain significance Single submitter
- ENTR1 p.Asp102Asn Uncertain significance Single submitter
- ENTR1 p.Asp144Gly Uncertain significance Single submitter
- ENTR1 p.Asp236Glu Uncertain significance Single submitter
- ENTR1 p.Asp23Glu Uncertain significance Single submitter
- ENTR1 p.Asp276Asn Uncertain significance Single submitter
- ENTR1 p.Asp316Asn Uncertain significance Single submitter
- ENTR1 p.Gln195His Uncertain significance Single submitter
- ENTR1 p.Glu104Ala Uncertain significance Single submitter
- ENTR1 p.Glu135Asp Uncertain significance Single submitter
- ENTR1 p.Glu165Lys Uncertain significance Single submitter
- ENTR1 p.Glu176Lys Uncertain significance Single submitter
- ENTR1 p.Glu194Lys Uncertain significance Single submitter
- ENTR1 p.Glu220Gly Uncertain significance Single submitter
- ENTR1 p.Glu410Lys Uncertain significance Single submitter
- ENTR1 p.Glu417Gln Uncertain significance Single submitter
- ENTR1 p.Glu417Lys Uncertain significance Single submitter
- ENTR1 p.Glu433Gly Uncertain significance Single submitter
- ENTR1 p.Gly183Arg Uncertain significance Single submitter
- ENTR1 p.Gly372Arg Uncertain significance Single submitter
- ENTR1 p.Gly372Ser Uncertain significance Single submitter
- ENTR1 p.Gly374Ala Uncertain significance Single submitter
- ENTR1 p.Gly44Asp Uncertain significance Single submitter
- ENTR1 p.Gly53Asp Uncertain significance Single submitter
- ENTR1 p.Gly89Ala Uncertain significance Single submitter
- ENTR1 p.Gly92Val Uncertain significance Single submitter
- ENTR1 p.Ile131Ser Uncertain significance Single submitter
- ENTR1 p.Ile311Met Uncertain significance Single submitter
- ENTR1 p.Ile311Thr Uncertain significance Single submitter
- ENTR1 p.Ile422Met Uncertain significance Single submitter
- ENTR1 p.Ile422Val Uncertain significance Single submitter
- ENTR1 p.Leu103Pro Uncertain significance Single submitter
- ENTR1 p.Leu120Phe Uncertain significance Single submitter
- ENTR1 p.Leu227Val Uncertain significance Single submitter
- ENTR1 p.Lys118Glu Uncertain significance Single submitter
- ENTR1 p.Lys79Asn Uncertain significance Single submitter
- ENTR1 p.Phe100Ile Uncertain significance Single submitter
- ENTR1 p.Phe362Leu Uncertain significance Single submitter
- ENTR1 p.Pro127Leu Uncertain significance Single submitter
- ENTR1 p.Pro12Arg Uncertain significance Single submitter
- ENTR1 p.Pro149Ser Uncertain significance Single submitter
- ENTR1 p.Pro190Leu Uncertain significance Single submitter
- ENTR1 p.Pro218Thr Uncertain significance Single submitter
- ENTR1 p.Pro244Leu Uncertain significance Single submitter
- ENTR1 p.Pro42Arg Uncertain significance Single submitter
- ENTR1 p.Pro87Leu Uncertain significance Single submitter
- ENTR1 p.Ser123Leu Uncertain significance Single submitter
- ENTR1 p.Ser123Trp Uncertain significance Single submitter
- ENTR1 p.Ser137Leu Uncertain significance Single submitter
- ENTR1 p.Ser137Trp Uncertain significance Single submitter
- ENTR1 p.Ser191Phe Uncertain significance Single submitter
- ENTR1 p.Ser219Leu Uncertain significance Single submitter
- ENTR1 p.Ser229Leu Uncertain significance Single submitter
- ENTR1 p.Ser233Asn Uncertain significance Single submitter
- ENTR1 p.Ser237Cys Uncertain significance Single submitter
- ENTR1 p.Ser243Cys Uncertain significance Single submitter
- ENTR1 p.Ser315Ile Uncertain significance Single submitter
- ENTR1 p.Ser322Leu Uncertain significance Single submitter
- ENTR1 p.Ser376Gly Uncertain significance Single submitter
- ENTR1 p.Ser426Phe Uncertain significance Single submitter
- ENTR1 p.Ser64Thr Uncertain significance Single submitter
- ENTR1 p.Ser69Cys Uncertain significance Single submitter
- ENTR1 p.Ser83Phe Uncertain significance Single submitter
- ENTR1 p.Ser86Asn Uncertain significance Single submitter
- ENTR1 p.Thr117Ala Uncertain significance Single submitter
- ENTR1 p.Thr217Ala Uncertain significance Single submitter
- ENTR1 p.Thr266Met Uncertain significance Single submitter
- ENTR1 p.Thr301Met Uncertain significance Single submitter
- ENTR1 p.Thr73Lys Uncertain significance Single submitter
- ENTR1 p.Trp184Gly Uncertain significance Single submitter
- ENTR1 p.Tyr132His Uncertain significance Single submitter
- ENTR1 p.Tyr159Cys Uncertain significance Single submitter
- ENTR1 p.Tyr28Cys Uncertain significance Single submitter
- ENTR1 p.Tyr61Cys Uncertain significance Single submitter
- ENTR1 p.Val239Met Uncertain significance Single submitter
- ENTR1 p.Val288Ile Uncertain significance Single submitter
- ENTR1 p.Val339Ile Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- ENTR1 p.Arg265Trp Uncertain significance Single submitter
- ENTR1 p.Arg364Pro Uncertain significance Single submitter
- ENTR1 p.Arg370Gly Uncertain significance Single submitter
- ENTR1 p.Asn383Asp Uncertain significance Single submitter
- ENTR1 p.Gln373Pro Uncertain significance Single submitter
- ENTR1 p.Glu277Asp Uncertain significance Single submitter
- ENTR1 p.Gly53Arg Uncertain significance Single submitter
- ENTR1 p.Gly71Arg Uncertain significance Single submitter
- ENTR1 p.Lys349Glu Uncertain significance Single submitter
- ENTR1 p.Phe111Tyr Uncertain significance Single submitter
- ENTR1 p.Pro108Leu Uncertain significance Single submitter
- ENTR1 p.Pro63Ser Uncertain significance Single submitter
All ENTR1 variants
Likely benign 4
- p.Ala384Thr Single submitter
- p.Asp430Glu Single submitter
- p.Gly121Ser Single submitter
- p.Val346Leu Single submitter
Uncertain significance 109
- p.Ala106Gly Single submitter ⚠
- p.Ala106Pro Single submitter ⚠
- p.Ala192Thr Single submitter ⚠
- p.Ala231Val Single submitter ⚠
- p.Ala250Ser Single submitter ⚠
- p.Ala253Val Single submitter ⚠
- p.Ala26Glu Single submitter ⚠
- p.Ala273Val Single submitter ⚠
- p.Ala357Val Single submitter ⚠
- p.Ala375Val Single submitter ⚠
- p.Arg238His Single submitter ⚠
- p.Arg265Trp Single submitter ⚠
- p.Arg30Leu Single submitter ⚠
- p.Arg364Pro Single submitter ⚠
- p.Arg370Gln Single submitter ⚠
- p.Arg370Gly Single submitter ⚠
- p.Arg41His Single submitter ⚠
- p.Arg424Lys Single submitter ⚠
- p.Arg424Thr Single submitter ⚠
- p.Arg55Trp Single submitter ⚠
- p.Arg99Ile Single submitter ⚠
- p.Asn361Ser Single submitter ⚠
- p.Asn383Asp Single submitter ⚠
- p.Asp102Asn Single submitter ⚠
- p.Asp144Gly Single submitter ⚠
- p.Asp236Glu Single submitter ⚠
- p.Asp23Glu Single submitter ⚠
- p.Asp276Asn Single submitter ⚠
- p.Asp316Asn Single submitter ⚠
- p.Gln195His Single submitter ⚠
- p.Gln289His Single submitter
- p.Gln373Pro Single submitter ⚠
- p.Glu104Ala Single submitter ⚠
- p.Glu135Asp Single submitter ⚠
- p.Glu165Lys Single submitter ⚠
- p.Glu176Lys Single submitter ⚠
- p.Glu194Lys Single submitter ⚠
- p.Glu220Gly Single submitter ⚠
- p.Glu277Asp Single submitter ⚠
- p.Glu410Lys Single submitter ⚠
- p.Glu417Gln Single submitter ⚠
- p.Glu417Lys Single submitter ⚠
- p.Glu433Gly Single submitter ⚠
- p.Gly183Arg Single submitter ⚠
- p.Gly372Arg Single submitter ⚠
- p.Gly372Ser Single submitter ⚠
- p.Gly374Ala Single submitter ⚠
- p.Gly44Asp Single submitter ⚠
- p.Gly53Arg Single submitter ⚠
- p.Gly53Asp Single submitter ⚠
- p.Gly71Arg Single submitter ⚠
- p.Gly89Ala Single submitter ⚠
- p.Gly92Val Single submitter ⚠
- p.Ile131Ser Single submitter ⚠
- p.Ile311Met Single submitter ⚠
- p.Ile311Thr Single submitter ⚠
- p.Ile422Met Single submitter ⚠
- p.Ile422Val Single submitter ⚠
- p.Leu103Pro Single submitter ⚠
- p.Leu120Phe Single submitter ⚠
- p.Leu227Val Single submitter ⚠
- p.Leu355Phe Single submitter
- p.Lys118Glu Single submitter ⚠
- p.Lys349Glu Single submitter ⚠
- p.Lys79Asn Single submitter ⚠
- p.Phe100Ile Single submitter ⚠
- p.Phe111Tyr Single submitter ⚠
- p.Phe362Leu Single submitter ⚠
- p.Pro108Leu Single submitter ⚠
- p.Pro127Leu Single submitter ⚠
- p.Pro12Arg Single submitter ⚠
- p.Pro149Ser Single submitter ⚠
- p.Pro190Leu Single submitter ⚠
- p.Pro218Thr Single submitter ⚠
- p.Pro244Leu Single submitter ⚠
- p.Pro42Arg Single submitter ⚠
- p.Pro63Ser Single submitter ⚠
- p.Pro87Leu Single submitter ⚠
- p.Ser123Leu Single submitter ⚠
- p.Ser123Trp Single submitter ⚠
- p.Ser137Leu Single submitter ⚠
- p.Ser137Trp Single submitter ⚠
- p.Ser191Phe Single submitter ⚠
- p.Ser219Leu Single submitter ⚠
- p.Ser229Leu Single submitter ⚠
- p.Ser233Asn Single submitter ⚠
- p.Ser237Cys Single submitter ⚠
- p.Ser243Cys Single submitter ⚠
- p.Ser315Ile Single submitter ⚠
- p.Ser322Leu Single submitter ⚠
- p.Ser376Gly Single submitter ⚠
- p.Ser426Phe Single submitter ⚠
- p.Ser64Thr Single submitter ⚠
- p.Ser69Cys Single submitter ⚠
- p.Ser83Phe Single submitter ⚠
- p.Ser86Asn Single submitter ⚠
- p.Thr117Ala Single submitter ⚠
- p.Thr217Ala Single submitter ⚠
- p.Thr266Met Single submitter ⚠
- p.Thr301Met Single submitter ⚠
- p.Thr73Lys Single submitter ⚠
- p.Trp184Gly Single submitter ⚠
- p.Tyr132His Single submitter ⚠
- p.Tyr159Cys Single submitter ⚠
- p.Tyr28Cys Single submitter ⚠
- p.Tyr61Cys Single submitter ⚠
- p.Val239Met Single submitter ⚠
- p.Val288Ile Single submitter ⚠
- p.Val339Ile Single submitter ⚠