EPYC — 56 ClinVar variants
All ClinVar germline EPYC variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
1 Benign · 2 Likely benign · 53 Uncertain significance
Full EPYC gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EPYC p.Ala137Val Uncertain significance Single submitter
- EPYC p.Ala16Thr Uncertain significance Single submitter
- EPYC p.Ala35Pro Uncertain significance Single submitter
- EPYC p.Arg194Gln Uncertain significance Single submitter
- EPYC p.Arg199His Uncertain significance Single submitter
- EPYC p.Arg261Gln Uncertain significance Single submitter
- EPYC p.Arg288His Uncertain significance Single submitter
- EPYC p.Arg315Cys Uncertain significance Single submitter
- EPYC p.Asn112Lys Uncertain significance Single submitter
- EPYC p.Asn42Ser Uncertain significance Single submitter
- EPYC p.Asp114Glu Uncertain significance Single submitter
- EPYC p.Cys121Tyr Uncertain significance Single submitter
- EPYC p.Glu100Asp Uncertain significance Single submitter
- EPYC p.His274Gln Uncertain significance Single submitter
- EPYC p.Ile218Val Uncertain significance Single submitter
- EPYC p.Ile294Val Uncertain significance Single submitter
- EPYC p.Ile301Thr Uncertain significance Single submitter
- EPYC p.Leu284Phe Uncertain significance Single submitter
- EPYC p.Lys305Glu Uncertain significance Single submitter
- EPYC p.Met236Leu Uncertain significance Single submitter
- EPYC p.Pro139Thr Uncertain significance Single submitter
- EPYC p.Pro140Leu Uncertain significance Single submitter
- EPYC p.Pro142Leu Uncertain significance Single submitter
- EPYC p.Pro90Ala Uncertain significance Single submitter
- EPYC p.Ser180Pro Uncertain significance Single submitter
- EPYC p.Ser25Tyr Uncertain significance Single submitter
- EPYC p.Ser320Arg Uncertain significance Single submitter
- EPYC p.Thr111Ala Uncertain significance Single submitter
- EPYC p.Thr127Pro Uncertain significance Single submitter
- EPYC p.Tyr129Cys Uncertain significance Single submitter
- EPYC p.Val106Ile Uncertain significance Single submitter
- EPYC p.Val106Phe Uncertain significance Single submitter
- EPYC p.Val128Met Uncertain significance Single submitter
- EPYC p.Val197Ile Uncertain significance Single submitter
- EPYC p.Val51Ala Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- EPYC p.Ala16Asp Uncertain significance Single submitter
- EPYC p.Arg199Cys Uncertain significance Single submitter
- EPYC p.Asp185His Uncertain significance Single submitter
- EPYC p.Asp250Ala Uncertain significance Single submitter
- EPYC p.Gln80His Uncertain significance Single submitter
- EPYC p.Glu85Ala Uncertain significance Single submitter
- EPYC p.Leu119Arg Uncertain significance Single submitter
- EPYC p.Leu11Phe Uncertain significance Single submitter
- EPYC p.Lys2Gln Uncertain significance Single submitter
- EPYC p.Met236Val Uncertain significance Single submitter
- EPYC p.Pro50His Uncertain significance Single submitter
- EPYC p.Ser219Asn Uncertain significance Single submitter
- EPYC p.Ser219Thr Uncertain significance Single submitter
- EPYC p.Ser96Cys Uncertain significance Single submitter
- EPYC p.Thr117Ile Uncertain significance Single submitter
- EPYC p.Tyr147His Uncertain significance Single submitter
- EPYC p.Val12Asp Uncertain significance Single submitter
- EPYC p.Val8Ala Uncertain significance Single submitter
All EPYC variants
Benign 1
- c.166-4del Single submitter
Likely benign 2
- c.702+1G>C Single submitter
- p.Arg188Ter Single submitter
Uncertain significance 53
- p.Ala137Val Single submitter ⚠
- p.Ala16Asp Single submitter ⚠
- p.Ala16Thr Single submitter ⚠
- p.Ala35Pro Single submitter ⚠
- p.Arg194Gln Single submitter ⚠
- p.Arg199Cys Single submitter ⚠
- p.Arg199His Single submitter ⚠
- p.Arg261Gln Single submitter ⚠
- p.Arg288His Single submitter ⚠
- p.Arg315Cys Single submitter ⚠
- p.Asn112Lys Single submitter ⚠
- p.Asn42Ser Single submitter ⚠
- p.Asp114Glu Single submitter ⚠
- p.Asp185His Single submitter ⚠
- p.Asp250Ala Single submitter ⚠
- p.Cys121Tyr Single submitter ⚠
- p.Gln80His Single submitter ⚠
- p.Glu100Asp Single submitter ⚠
- p.Glu85Ala Single submitter ⚠
- p.His274Gln Single submitter ⚠
- p.Ile218Val Single submitter ⚠
- p.Ile294Val Single submitter ⚠
- p.Ile301Thr Single submitter ⚠
- p.Leu119Arg Single submitter ⚠
- p.Leu11Phe Single submitter ⚠
- p.Leu284Phe Single submitter ⚠
- p.Lys2Gln Single submitter ⚠
- p.Lys305Glu Single submitter ⚠
- p.Met236Leu Single submitter ⚠
- p.Met236Val Single submitter ⚠
- p.Pro139Thr Single submitter ⚠
- p.Pro140Leu Single submitter ⚠
- p.Pro142Leu Single submitter ⚠
- p.Pro50His Single submitter ⚠
- p.Pro90Ala Single submitter ⚠
- p.Ser180Pro Single submitter ⚠
- p.Ser219Asn Single submitter ⚠
- p.Ser219Thr Single submitter ⚠
- p.Ser25Tyr Single submitter ⚠
- p.Ser320Arg Single submitter ⚠
- p.Ser96Cys Single submitter ⚠
- p.Thr111Ala Single submitter ⚠
- p.Thr117Ile Single submitter ⚠
- p.Thr127Pro Single submitter ⚠
- p.Tyr129Cys Single submitter ⚠
- p.Tyr147His Single submitter ⚠
- p.Val106Ile Single submitter ⚠
- p.Val106Phe Single submitter ⚠
- p.Val128Met Single submitter ⚠
- p.Val12Asp Single submitter ⚠
- p.Val197Ile Single submitter ⚠
- p.Val51Ala Single submitter ⚠
- p.Val8Ala Single submitter ⚠