ERG — 51 ClinVar variants
All ClinVar germline ERG variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
3 Pathogenic · 1 Likely benign · 47 Uncertain significance
Full ERG gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
-
ERG p.Ala368Thr
Uncertain significance
Single submitter
acute lymphoblastic leukemia
- ERG p.Ala387Pro Uncertain significance Single submitter
- ERG p.Ala88Asp Uncertain significance Single submitter
- ERG p.Arg302His Uncertain significance Single submitter
- ERG p.Asn336Thr Uncertain significance Single submitter
- ERG p.Asn80Lys Uncertain significance Single submitter
-
ERG p.Asp363Asn
Uncertain significance
Single submitter
acute lymphoblastic leukemia
-
ERG p.Asp363Gly
Uncertain significance
Single submitter
acute lymphoblastic leukemia
- ERG p.Asp40Asn Uncertain significance Single submitter
- ERG p.Cys85Tyr Uncertain significance Single submitter
- ERG p.Gln161Glu Uncertain significance Single submitter
- ERG p.Gly101Glu Uncertain significance Single submitter
- ERG p.Gly394Arg Uncertain significance Single submitter
- ERG p.Met418Leu Uncertain significance Single submitter
- ERG p.Phe339Leu Uncertain significance Single submitter
- ERG p.Pro116Arg Uncertain significance Single submitter
- ERG p.Pro254Ser Uncertain significance Single submitter
- ERG p.Pro298Leu Uncertain significance Single submitter
- ERG p.Pro433Ser Uncertain significance Single submitter
- ERG p.Pro436Ser Uncertain significance Single submitter
- ERG p.Pro60Thr Uncertain significance Single submitter
- ERG p.Pro82Thr Uncertain significance Single submitter
- ERG p.Pro97Ala Uncertain significance Single submitter
- ERG p.Ser270Thr Uncertain significance Single submitter
- ERG p.Ser469Gly Uncertain significance Single submitter
- ERG p.Thr120Lys Uncertain significance Single submitter
- ERG p.Val100Asp Uncertain significance Single submitter
- ERG p.Val155Ile Uncertain significance Single submitter
- ERG p.Val51Ile Uncertain significance Single submitter
- ERG p.Val87Ala Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- ERG p.Arg178Gly Uncertain significance Single submitter
- ERG p.Arg287His Uncertain significance Single submitter
- ERG p.Arg287Ser Uncertain significance Single submitter
- ERG p.Asp175Asn Uncertain significance Single submitter
- ERG p.Glu197Lys Uncertain significance Single submitter
- ERG p.Gly226Val Uncertain significance Single submitter
- ERG p.Ile230Ser Uncertain significance Single submitter
-
ERG p.Met219Ile
Uncertain significance
Single submitter
acute lymphoblastic leukemia
- ERG p.Pro266Arg Uncertain significance Single submitter
- ERG p.Ser37Phe Uncertain significance Single submitter
- ERG p.Tyr183Cys Uncertain significance Single submitter
- ERG p.Val280Met Uncertain significance Single submitter
All ERG variants
Pathogenic 3
- p.Asn463fs No assertion criteria lymphatic malformation 14
- p.Ser182fs No assertion criteria lymphatic malformation 14
- p.Thr224fs No assertion criteria lymphatic malformation 14
Likely benign 1
- p.Asn121= Single submitter
Uncertain significance 47
- c.40-56923A>G Single submitter
- c.674-1G>A Single submitter
- p.Ala368Thr Single submitter acute lymphoblastic leukemia ⚠
- p.Ala387Pro Single submitter ⚠
- p.Ala88Asp Single submitter ⚠
- p.Arg178Gly Single submitter ⚠
- p.Arg287His Single submitter ⚠
- p.Arg287Ser Single submitter ⚠
- p.Arg302His Single submitter ⚠
- p.Asn336Thr Single submitter ⚠
- p.Asn80Lys Single submitter ⚠
- p.Asp175Asn Single submitter ⚠
- p.Asp363Asn Single submitter acute lymphoblastic leukemia ⚠
- p.Asp363Gly Single submitter acute lymphoblastic leukemia ⚠
- p.Asp40Asn Single submitter ⚠
- p.Cys85Tyr Single submitter ⚠
- p.Gln161Glu Single submitter ⚠
- p.Glu197Lys Single submitter ⚠
- p.Gly101Glu Single submitter ⚠
- p.Gly226Val Single submitter ⚠
- p.Gly394Arg Single submitter ⚠
- p.His191delinsArgAsn Single submitter acute lymphoblastic leukemia
- p.Ile230Ser Single submitter ⚠
- p.Met219Ile Single submitter acute lymphoblastic leukemia ⚠
- p.Met418Leu Single submitter ⚠
- p.Phe339Leu Single submitter ⚠
- p.Pro116Arg Single submitter ⚠
- p.Pro254Ser Single submitter ⚠
- p.Pro266Arg Single submitter ⚠
- p.Pro298Leu Single submitter ⚠
- p.Pro433Ser Single submitter ⚠
- p.Pro436Ser Single submitter ⚠
- p.Pro60Thr Single submitter ⚠
- p.Pro6Leu Single submitter
- p.Pro82Thr Single submitter ⚠
- p.Pro97Ala Single submitter ⚠
- p.Ser270Thr Single submitter ⚠
- p.Ser37Phe Single submitter ⚠
- p.Ser413fs Single submitter
- p.Ser469Gly Single submitter ⚠
- p.Thr120Lys Single submitter ⚠
- p.Tyr183Cys Single submitter ⚠
- p.Val100Asp Single submitter ⚠
- p.Val155Ile Single submitter ⚠
- p.Val280Met Single submitter ⚠
- p.Val51Ile Single submitter ⚠
- p.Val87Ala Single submitter ⚠