FCER2 — 56 ClinVar variants
All ClinVar germline FCER2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
7 Likely benign · 49 Uncertain significance
Full FCER2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 39
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FCER2 p.Ala246Asp Uncertain significance Single submitter
- FCER2 p.Ala246Ser Uncertain significance Single submitter
- FCER2 p.Ala271Asp Uncertain significance Single submitter
- FCER2 p.Ala33Thr Uncertain significance Single submitter
- FCER2 p.Ala36Val Uncertain significance Single submitter
- FCER2 p.Arg142Trp Uncertain significance Single submitter
- FCER2 p.Arg14Ser Uncertain significance Single submitter
- FCER2 p.Arg16Gln Uncertain significance Single submitter
- FCER2 p.Arg16Trp Uncertain significance Single submitter
- FCER2 p.Arg188Gln Uncertain significance Single submitter
- FCER2 p.Arg20Cys Uncertain significance Single submitter
- FCER2 p.Arg20His Uncertain significance Single submitter
- FCER2 p.Arg275His Uncertain significance Single submitter
- FCER2 p.Asp193Asn Uncertain significance Single submitter
- FCER2 p.Asp236Gly Uncertain significance Single submitter
- FCER2 p.Asp303Val Uncertain significance Single submitter
- FCER2 p.Cys174Arg Uncertain significance Single submitter
- FCER2 p.Cys174Ser Uncertain significance Single submitter
- FCER2 p.Glu10Lys Uncertain significance Single submitter
- FCER2 p.Glu206Lys Uncertain significance Single submitter
- FCER2 p.Glu231Gln Uncertain significance Single submitter
- FCER2 p.Glu298Lys Uncertain significance Single submitter
- FCER2 p.Gly115Glu Uncertain significance Single submitter
- FCER2 p.Gly218Ser Uncertain significance Single submitter
- FCER2 p.Ile88Val Uncertain significance Single submitter
- FCER2 p.Leu102Ser Uncertain significance Single submitter
- FCER2 p.Leu92Val Uncertain significance Single submitter
- FCER2 p.Met194Thr Uncertain significance Single submitter
- FCER2 p.Pro204Leu Uncertain significance Single submitter
- FCER2 p.Pro306Ser Uncertain significance Single submitter
- FCER2 p.Pro313Ser Uncertain significance Single submitter
- FCER2 p.Ser215Thr Uncertain significance Single submitter
- FCER2 p.Ser219Phe Uncertain significance Single submitter
- FCER2 p.Ser316Pro Uncertain significance Single submitter
- FCER2 p.Thr31Ile Uncertain significance Single submitter
- FCER2 p.Thr49Ile Uncertain significance Single submitter
- FCER2 p.Thr86Met Uncertain significance Single submitter
- FCER2 p.Trp184Leu Uncertain significance Single submitter
- FCER2 p.Val185Phe Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- FCER2 p.Arg267Pro Uncertain significance Single submitter
- FCER2 p.Arg275Cys Uncertain significance Single submitter
- FCER2 p.Arg284Trp Uncertain significance Single submitter
- FCER2 p.Gln153Pro Uncertain significance Single submitter
- FCER2 p.Gly196Arg Uncertain significance Single submitter
- FCER2 p.Gly266Arg Uncertain significance Single submitter
- FCER2 p.Gly28Glu Uncertain significance Single submitter
- FCER2 p.Gly37Glu Uncertain significance Single submitter
- FCER2 p.Leu34Arg Uncertain significance Single submitter
- FCER2 p.Val260Met Uncertain significance Single submitter
All FCER2 variants
Likely benign 7
- p.Arg263Gln Single submitter
- p.Arg62Gln Single submitter
- p.Asn70Asp Single submitter
- p.Gly115Arg Single submitter
- p.Gly310Ser Single submitter
- p.Gly76= Single submitter
- p.Leu319fs Single submitter
Uncertain significance 49
- p.Ala246Asp Single submitter ⚠
- p.Ala246Ser Single submitter ⚠
- p.Ala271Asp Single submitter ⚠
- p.Ala33Thr Single submitter ⚠
- p.Ala36Val Single submitter ⚠
- p.Arg142Trp Single submitter ⚠
- p.Arg14Ser Single submitter ⚠
- p.Arg16Gln Single submitter ⚠
- p.Arg16Trp Single submitter ⚠
- p.Arg188Gln Single submitter ⚠
- p.Arg20Cys Single submitter ⚠
- p.Arg20His Single submitter ⚠
- p.Arg267Pro Single submitter ⚠
- p.Arg275Cys Single submitter ⚠
- p.Arg275His Single submitter ⚠
- p.Arg284Trp Single submitter ⚠
- p.Asp193Asn Single submitter ⚠
- p.Asp236Gly Single submitter ⚠
- p.Asp303Val Single submitter ⚠
- p.Cys174Arg Single submitter ⚠
- p.Cys174Ser Single submitter ⚠
- p.Gln153Pro Single submitter ⚠
- p.Glu10Lys Single submitter ⚠
- p.Glu206Lys Single submitter ⚠
- p.Glu231Gln Single submitter ⚠
- p.Glu298Lys Single submitter ⚠
- p.Gly115Glu Single submitter ⚠
- p.Gly196Arg Single submitter ⚠
- p.Gly218Ser Single submitter ⚠
- p.Gly266Arg Single submitter ⚠
- p.Gly28Glu Single submitter ⚠
- p.Gly37Glu Single submitter ⚠
- p.Ile88Val Single submitter ⚠
- p.Leu102Ser Single submitter ⚠
- p.Leu34Arg Single submitter ⚠
- p.Leu92Val Single submitter ⚠
- p.Met194Thr Single submitter ⚠
- p.Pro204Leu Single submitter ⚠
- p.Pro306Ser Single submitter ⚠
- p.Pro313Ser Single submitter ⚠
- p.Ser215Thr Single submitter ⚠
- p.Ser219Phe Single submitter ⚠
- p.Ser316Pro Single submitter ⚠
- p.Thr31Ile Single submitter ⚠
- p.Thr49Ile Single submitter ⚠
- p.Thr86Met Single submitter ⚠
- p.Trp184Leu Single submitter ⚠
- p.Val185Phe Single submitter ⚠
- p.Val260Met Single submitter ⚠