FCGR2A — 75 ClinVar variants

All ClinVar germline FCGR2A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →

1 Conflicting · 7 Benign · 1 Benign/Likely benign · 13 Likely benign · 53 Uncertain significance

Full FCGR2A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 52

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

FCGR2A p.Met216Ile Conflicting Single submitter

Predictors lean, ClinVar uncertain 45

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 6

The independent predictors disagree with each other — read with care.

All FCGR2A variants

Conflicting classifications of pathogenicity 1

p.Met216Ile Single submitter ⚠

Benign 7

c.365-11G>A Multiple submitters
p.Gln63Arg Multiple submitters
p.Gln63Ter Multiple submitters
p.His167Arg Multiple submitters
p.Pro215= Multiple submitters
p.Pro293= Multiple submitters
p.Arg245Trp Single submitter

Benign/Likely benign 1

p.Ser70= Multiple submitters

Likely benign 13

c.619+6G>A Single submitter
c.619+6G>C Single submitter
p.Ala225Gly Single submitter
p.Arg245Gln Single submitter
p.Asp280Ala Single submitter
p.His85Gln Single submitter
p.Ile224Thr Single submitter
p.Met140Val Single submitter
p.Thr171Asn Single submitter
p.Thr226Ile Single submitter
p.Asn51= No assertion criteria FCGR2A-related disorder
p.Pro48= No assertion criteria FCGR2A-related disorder
p.Ser121= No assertion criteria

Uncertain significance 53

c.780+1G>A Multiple submitters malaria, susceptibility to
p.Ser315Gly Multiple submitters ⚠
c.106+1G>T Single submitter
p.Ala227Thr Single submitter ⚠
p.Ala230Val Single submitter ⚠
p.Ala284Val Single submitter ⚠
p.Ala94Val Single submitter ⚠
p.Arg142Lys Single submitter ⚠
p.Arg264Cys Single submitter ⚠
p.Arg264His Single submitter ⚠
p.Arg66Cys Single submitter ⚠
p.Asn302Lys Single submitter ⚠
p.Asp252Glu Single submitter ⚠
p.Asp298Ala Single submitter ⚠
p.Asp299Asn Single submitter ⚠
p.Gln74Pro Single submitter ⚠
p.Gly287Ser Single submitter ⚠
p.His312Asn Single submitter ⚠
p.Ile191Thr Single submitter ⚠
p.Ile219Thr Single submitter ⚠
p.Ile267Leu Single submitter ⚠
p.Ile267Met Single submitter ⚠
p.Ile73Ser Single submitter ⚠
p.Leu25Phe Single submitter ⚠
p.Lys301Glu Single submitter ⚠
p.Lys40Arg Single submitter ⚠
p.Met289Val Single submitter ⚠
p.Phe172Leu Single submitter ⚠
p.Phe259Ser Single submitter ⚠
p.Pro114Leu Single submitter ⚠
p.Pro129Leu Single submitter ⚠
p.Pro150Ala Single submitter ⚠
p.Pro150Arg Single submitter ⚠
p.Pro170Leu Single submitter ⚠
p.Pro253Leu Single submitter ⚠
p.Pro293Ala Single submitter ⚠
p.Pro39Gln Single submitter ⚠
p.Pro83Ala Single submitter ⚠
p.Ser166Phe Single submitter cystic fibrosis ⚠
p.Ser209Thr Single submitter ⚠
p.Ser212Asn Single submitter ⚠
p.Ser212Thr Single submitter ⚠
p.Ser315Asn Single submitter ⚠
p.Ser315Cys Single submitter ⚠
p.Ser57Pro Single submitter ⚠
p.Ser8Pro Single submitter ⚠
p.Thr103Met Single submitter ⚠
p.Thr194Met Single submitter ⚠
p.Thr86Met Single submitter ⚠
p.Tyr102Cys Single submitter ⚠
p.Tyr185Cys Single submitter ⚠
p.Val205Ala Single submitter ⚠
p.Val235Ile Single submitter ⚠