Sugi Variant

Sugi Variant/FGB

FGB — 270 ClinVar variants

All ClinVar germline FGB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 121 flagged for review →

10 Pathogenic · 2 Pathogenic/Likely pathogenic · 8 Likely pathogenic · 11 Conflicting · 33 Benign · 7 Benign/Likely benign · 39 Likely benign · 160 Uncertain significance

Full FGB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 121

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 2

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 8

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 81

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 30

The independent predictors disagree with each other — read with care.

All FGB variants

Pathogenic 10

Pathogenic/Likely pathogenic 2

  • p.Arg44Cys Multiple submitters familial dysfibrinogenemia ⚠
  • p.Arg47Ter Multiple submitters FGB-related disorder

Likely pathogenic 8

Conflicting classifications of pathogenicity 11

Benign 33

Benign/Likely benign 7

Likely benign 39

Uncertain significance 160