FGF2 — 41 ClinVar variants
All ClinVar germline FGF2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
5 Likely benign · 36 Uncertain significance
Full FGF2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FGF2 c.-113G>C Uncertain significance Single submitter
- FGF2 c.-116G>A Uncertain significance Single submitter
- FGF2 c.-129G>A Uncertain significance Single submitter
- FGF2 c.-156C>A Uncertain significance Single submitter
- FGF2 c.-162G>A Uncertain significance Single submitter
- FGF2 c.-174G>T Uncertain significance Single submitter
- FGF2 c.-198C>G Uncertain significance Single submitter
- FGF2 c.-209G>T Uncertain significance Single submitter
- FGF2 c.-219G>A Uncertain significance Single submitter
- FGF2 c.-21C>G Uncertain significance Single submitter
- FGF2 c.-237C>T Uncertain significance Single submitter
- FGF2 c.-26G>A Uncertain significance Single submitter
- FGF2 c.-276C>A Uncertain significance Single submitter
- FGF2 c.-276C>G Uncertain significance Single submitter
- FGF2 c.-294G>A Uncertain significance Single submitter
- FGF2 c.-311A>G Uncertain significance Single submitter
- FGF2 c.-317G>T Uncertain significance Single submitter
- FGF2 c.-62G>A Uncertain significance Single submitter
- FGF2 c.-66C>T Uncertain significance Single submitter
- FGF2 c.-99G>C Uncertain significance Single submitter
- FGF2 p.Arg116Gln Uncertain significance Single submitter
- FGF2 p.Asn113Asp Uncertain significance Single submitter
- FGF2 p.Gly37Arg Uncertain significance Single submitter
- FGF2 p.Ile74Val Uncertain significance Single submitter
- FGF2 p.Leu62Val Uncertain significance Single submitter
- FGF2 p.Leu91Ser Uncertain significance Single submitter
- FGF2 p.Lys119Arg Uncertain significance Single submitter
- FGF2 p.Pro23Ser Uncertain significance Single submitter
- FGF2 p.Thr98Met Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- FGF2 p.Lys61Asn Likely benign Multiple submitters
- FGF2 c.-113G>A Uncertain significance Single submitter
- FGF2 p.Arg116Trp Uncertain significance Single submitter
- FGF2 p.Glu100Asp Uncertain significance Single submitter
- FGF2 p.Ile146Thr Uncertain significance Single submitter
- FGF2 p.Lys154Gln Uncertain significance Single submitter
- FGF2 p.Ser152Phe Uncertain significance Single submitter
All FGF2 variants
Likely benign 5
Uncertain significance 36
- c.-113G>A Single submitter ⚠
- c.-113G>C Single submitter ⚠
- c.-116G>A Single submitter ⚠
- c.-129G>A Single submitter ⚠
- c.-156C>A Single submitter ⚠
- c.-162G>A Single submitter ⚠
- c.-174G>T Single submitter ⚠
- c.-198C>G Single submitter ⚠
- c.-209G>T Single submitter ⚠
- c.-219G>A Single submitter ⚠
- c.-21C>G Single submitter ⚠
- c.-237C>T Single submitter ⚠
- c.-26G>A Single submitter ⚠
- c.-276C>A Single submitter ⚠
- c.-276C>G Single submitter ⚠
- c.-294G>A Single submitter ⚠
- c.-311A>G Single submitter ⚠
- c.-317G>T Single submitter ⚠
- c.-62G>A Single submitter ⚠
- c.-66C>T Single submitter ⚠
- c.-99G>C Single submitter ⚠
- p.Arg116Gln Single submitter ⚠
- p.Arg116Trp Single submitter ⚠
- p.Asn113Asp Single submitter ⚠
- p.Glu100Asp Single submitter ⚠
- p.Gly37Arg Single submitter ⚠
- p.Ile146Thr Single submitter ⚠
- p.Ile74Val Single submitter ⚠
- p.Leu62Val Single submitter ⚠
- p.Leu91Ser Single submitter ⚠
- p.Lys119Arg Single submitter ⚠
- p.Lys154Gln Single submitter ⚠
- p.Pro23Ser Single submitter ⚠
- p.Ser152Phe Single submitter ⚠
- p.Thr98Met Single submitter ⚠
- p.Tyr133Cys Single submitter